Abstract:
:We recently presented evidence that distinct morphine and enkephalin receptors coexist in an opioid receptor complex (Mol. Pharmacol. 21:548-557, 1982). In this paper, we present data which demonstrate that in the presence of sodium leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to a crude particulate fraction of rat brain. Since the binding site labeled by [3H]naloxone in the presence of sodium may be an alternate conformation of the morphine receptor, these data provide further evidence that morphine and enkephalin receptors are allosterically coupled.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Rothman RB,Westfall TCdoi
10.1007/BF00964552subject
Has Abstractpub_date
1983-07-01 00:00:00pages
913-31issue
7eissn
0364-3190issn
1573-6903journal_volume
8pub_type
杂志文章abstract::There is increasing evidence to suggest that hepatic encephalopathy in acute liver failure is the result of altered glutamatergic function. In particular, the high affinity uptake of glutamate is decreased in brain slices and synaptosomes from rats with acute liver failure as well as by exposure of cultured astrocytes...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022532623281
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doi:10.1007/s11064-006-9124-9
更新日期:2006-09-01 00:00:00
abstract::Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...
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doi:10.1007/s11064-008-9608-x
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journal_title:Neurochemical research
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更新日期:2014-02-01 00:00:00
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journal_title:Neurochemical research
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doi:10.1007/s11064-011-0433-2
更新日期:2011-09-01 00:00:00
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journal_title:Neurochemical research
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更新日期:1989-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022530508763
更新日期:1999-02-01 00:00:00
abstract::Presenilins (PSs) are catalytic components of the γ-secretase complex that produces Aβ peptides. Substrates of γ-secretase are membrane-bound protein fragments deriving from the cleavage of extracellular sequence of cell surface proteins. APP-derived γ-secretase substrates are cleaved at gamma (γ) sites to produce Aβ ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-013-1003-6
更新日期:2014-01-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-004-6869-x
更新日期:2004-11-01 00:00:00
abstract::Rats were long-term morphine-intoxicated by a fluid-diet model ensuring an equal nutrient intake in morphinized and control rats. Uptake of neurotransmitters and D-ala2-met5-enkephalinamide (Enk) was studied in the particulate fractions (obtained at 10,000 g) from well defined brain regions of long-term intoxicated an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967978
更新日期:1986-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9127-6
更新日期:2007-02-01 00:00:00
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journal_title:Neurochemical research
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更新日期:2004-05-01 00:00:00
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doi:10.1007/s11064-020-03078-z
更新日期:2020-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963918
更新日期:1983-02-01 00:00:00
abstract::Diisopropyl phosphorofluoridate (DFP) produces organophosphorus ester-induced delayed neurotoxicity (OPIDN) in sensitive species. We have investigated the in vivo and in vitro effects of DFP on hen brain tubulin polymerization. Hens were treated with a single dose of DFP (1.7 mg/kg, sc.), and were sacrificed after 18-...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967321
更新日期:1994-04-01 00:00:00
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journal_title:Neurochemical research
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更新日期:2018-03-01 00:00:00
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journal_title:Neurochemical research
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更新日期:2017-11-01 00:00:00
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journal_title:Neurochemical research
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doi:10.1007/BF02529132
更新日期:1996-02-01 00:00:00
abstract::Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1753-4
更新日期:2016-04-01 00:00:00
abstract::The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...
journal_title:Neurochemical research
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更新日期:2013-03-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1012353005489
更新日期:2001-09-01 00:00:00
abstract::The purpose of this study was to investigate whether the kappa-opioid receptor (KOR) agonist, BRL52537, has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in rats and further explore the underlying mechanisms. Adult male Sprague-Dawley rats were randomly assigned into sham (group A), I/R (...
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更新日期:2013-11-01 00:00:00
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更新日期:2016-06-01 00:00:00
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更新日期:2008-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1874-4
更新日期:2016-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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