Abstract:
:Multiple sclerosis (MS) is a demyelinating disease that affects the central nervous system. MS is the most common neurological disorder in young adults with a greater incidence among females. Male gonadal hormones have a protective effect on neural system development and myelin maturation. In this study, we investigate the effect of castration on lysolecithin-induced demyelination and remyelination processes using visual evoked potentials, in addition to measuring the expressions of Olig2, MBP, Nogo-A and GFAP mRNAs as oligodendrocyte or astrocyte markers; and histological assessments by myelin-specific staining. We observed more expanded demyelination with delayed repair process in castrated rats. Expression levels of the aforementioned marker genes confirmed histological and electrophysiological observations. Our results showed a pivotal role for endogenous male hormones in the context of demyelinating insults. It may also account for the different prognosis of MS between male and female genders and provide new insights for therapeutic treatments.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Sherafat MA,Javan M,Mozafari S,Mirnajafi-Zadeh J,Motamedi Fdoi
10.1007/s11064-011-0510-6subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1887-95issue
10eissn
0364-3190issn
1573-6903journal_volume
36pub_type
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