Lidocaine Attenuates Cognitive Impairment After Isoflurane Anesthesia by Reducing Mitochondrial Damage.

abstract：:Danhong injection, a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is used extensively for the treatment of cerebrovascular diseases such as acutely cerebral infarction in clinic. In this study, we further investigated the mechanisms of Danhong inje...

journal_title：Neurochemical research

authors： Guo H,Li MJ,Liu QQ,Guo LL,Ma MM,Wang SX,Yu B,Hu LM

更新日期：2014-09-01 00:00:00

abstract：:The release of endogenous amino acids from depolarized rat hippocampal mossy fiber synaptosomes was investigated to assess the possible role(s) of glutamate and aspartate in mediating the excitatory mossy fiber synaptic input. The relative proportions of prodynorphin-derived peptides concomitantly released with amino ...

journal_title：Neurochemical research

authors： Terrian DM,Gannon RL,Rea MA

更新日期：1990-01-01 00:00:00

abstract：:Using sodium (NaN3)-induced anoxia plus aglycaemia as a model of chemically-induced ischemia, we have characterized the endogenous release of excitatory and inhibitory amino acids from superfused hippocampal slices. Chemical ischemia produced an azide (1-30 mM) dose-dependent increase in the efflux of glutamate, aspar...

journal_title：Neurochemical research

authors： Djali S,Dawson LA

更新日期：2001-02-01 00:00:00

abstract：:Two major glycoproteins, P0 and PASII/PMP22, are specifically expressed in peripheral myelin. Point mutations of these proteins and over or under expression of PASII/PMP22 cause various hereditary peripheral neuropathies. P0 is well characterized as a major adhesion molecule in PNS myelin, but the function of PASII/PM...

journal_title：Neurochemical research

authors： Takeda Y,Notsu T,Kitamura K,Uyemura K

更新日期：2001-06-01 00:00:00

abstract：UNLABELLED:Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B pr...

journal_title：Neurochemical research

authors： Ribeiro L,Andreazza AC,Salvador M,da Silveira TR,Vieira S,Nora DB,Bosa C,Di Napoli F,Schaf DV,Souza DO,Portela LV,Kapczinski F

更新日期：2007-09-01 00:00:00

abstract：:Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...

journal_title：Neurochemical research

authors： Yarom M,Bao J,Tang XW,Wu E,Lee YH,Tsai WH,Wu JY

更新日期：1992-01-01 00:00:00

abstract：:Recent evidence has linked striatal amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor function to the adverse effects of long-term dopaminergic treatment in Parkinson's disease. The phosphorylation of AMPA subunit, GluR1, reflects AMPA receptor activity. To determine whether serine phosphorylation of...

journal_title：Neurochemical research

authors： Ba M,Kong M,Yang H,Ma G,Lu G,Chen S,Liu Z

更新日期：2006-11-01 00:00:00

abstract：:Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...

journal_title：Neurochemical research

authors： Klinar B,Kamarić L,Sketelj J,Brzin M

更新日期：1985-06-01 00:00:00

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:Antidepressive drugs offer considerable symptomatic relief in mood disorders and, although commonly discovered by screening with single biological targets, most interact with multiple receptors and signaling pathways. Antidepressants require a treatment regimen of several weeks before clinical efficacy is achieved in ...

journal_title：Neurochemical research

authors： Kálmán J,Palotás A,Juhász A,Rimanóczy A,Hugyecz M,Kovács Z,Galsi G,Szabó Z,Pákáski M,Fehér LZ,Janka Z,Puskás LG

更新日期：2005-11-01 00:00:00

abstract：:The levels of selected neuroregulatory proteins that inhibit or promote apoptotic cell death were measured in the striatum of piglets subjected to precisely controlled 1 h hypoxic insult followed by 0, 2 and 4 h recovery and compared to sham operated animals. The anti-apoptotic proteins: there were increases in Surviv...

journal_title：Neurochemical research

authors： Mammen A,Kubin J,Greeley WJ,Schears GJ,Pastuszko P,F Wilson D,Pastuszko A

更新日期：2011-05-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we i...

journal_title：Neurochemical research

authors： Watanabe R,Kurose T,Morishige Y,Fujimori K

更新日期：2018-02-01 00:00:00

abstract：:Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlyin...

journal_title：Neurochemical research

authors： Zhou HL,Zhang XJ,Zhang MY,Yan ZJ,Xu ZM,Xu RX

更新日期：2016-10-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00

abstract：:Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...

journal_title：Neurochemical research

authors： Kennedy SH,Davis BA,Brown GM,Ford CG,d'Souza J

更新日期：1993-12-01 00:00:00

abstract：:The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...

journal_title：Neurochemical research

authors： Yoshino Y

更新日期：1984-03-01 00:00:00

abstract：:Evidence that brain glutamatergic activity is pathologically elevated in bipolar disorder suggests that mood stabilizers are therapeutic in the disease in part by downregulating glutamatergic activity. Such activity can involve the second messenger, arachidonic acid (AA, 20:4n - 6). We tested this hypothesis with rega...

journal_title：Neurochemical research

authors： Basselin M,Chang L,Chen M,Bell JM,Rapoport SI

更新日期：2008-11-01 00:00:00

abstract：:Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...

journal_title：Neurochemical research

authors： Mutsuga N,Gainer H

更新日期：2006-02-01 00:00:00

abstract：:The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...

journal_title：Neurochemical research

authors： Myles ME,Gokmen-Polar Y,Fain JN

更新日期：1995-09-01 00:00:00

abstract：:Mammalian MTH1 protein, a MutT-related protein, catalyzes the hydrolysis of 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) to monophosphate, thereby preventing incorporation of 8-oxo-7,8-dihydroguanine (8-oxoguanine) into RNA. In this study, we applied immunohistochemistry to follow the expression of MTH1 and the ...

journal_title：Neurochemical research

authors： Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP

更新日期：2011-08-01 00:00:00

abstract：:Propofol and ketamine may provide certain degree of neuroprotection, but the underlying mechanism remains unclear to date. The cAMP response element-binding protein (CREB) was proposed that its phosphorylation at Ser133 (P-CREB) constituted a convergence point involved in neuroprotection. The purpose of this study was...

journal_title：Neurochemical research

authors： Shu L,Li T,Han S,Ji F,Pan C,Zhang B,Li J

更新日期：2012-01-01 00:00:00

abstract：:Exercise increases both the consumption of oxygen and the production of reactive species in biological tissues, and this is counterbalanced by antioxidant adaptations to regular physical training. When the intensity of exercise fluctuates between mild and moderate, it improves the status of reduction-oxidation balance...

journal_title：Neurochemical research

authors： Speck AE,Tromm CB,Pozzi BG,Paganini CS,Tuon T,Silveira PC,Aguiar AS Jr,Pinho RA

更新日期：2014-08-01 00:00:00

abstract：:Several previous studies utilizing selective pharmacological antagonists have demonstrated that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for the treatment of numerous disorders of the central nervous system, but the role of mGluR5 activation in traumatic brain injury (TBI) is ...

journal_title：Neurochemical research

authors： Chen T,Cao L,Dong W,Luo P,Liu W,Qu Y,Fei Z

更新日期：2012-05-01 00:00:00

abstract：:The effect of oxidative stress, induced by Fe(2+)-EDTA system, on Na+,K(+)-ATPase, Na+/CA2+ exchanger and membrane fluidity of synaptosomes was investigated. Synaptosomes isolated from gerbil whole forebrain were incubated in the presence of 200 microM FeSO4-EDTA per mg of protein at 37 degrees C for 30 min. The oxida...

journal_title：Neurochemical research

authors： Kaplán P,Matejovicová M,Mézesová V

更新日期：1997-12-01 00:00:00

abstract：:Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alc...

journal_title：Neurochemical research

authors： Priyanka SH,Syam Das S,Thushara AJ,Rauf AA,Indira M

更新日期：2018-09-01 00:00:00

abstract：:Spinal cord injury (SCI) is a type of long-term disability with a high morbidity rate in clinical settings for which there is no effective clinical treatment to date. Usually, lithium is used as a popular mood stabilizer. Recently, growing evidence has shown that lithium has clear neuroprotective effects after SCI, an...

journal_title：Neurochemical research

authors： Li B,Ren J,Yang L,Li X,Sun G,Xia M

更新日期：2018-04-01 00:00:00

abstract：:There is a growing body of evidence confirming the involvement of oxidative stress and inflammation in pathogenesis of schizophrenia. Inter-individual variation in antioxidant capacity caused by different genetic profile could potentially influence patient's susceptibility to oxidative damage. In this study we evaluat...

journal_title：Neurochemical research

authors： Bošković M,Vovk T,Saje M,Goričar K,Dolžan V,Kores Plesničar B,Grabnar I

更新日期：2013-02-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces type I organophosphorus ester-induced delayed neurotoxicity in humans and sensitive animal species. This is accompanied by enhanced Ca2+/CaM-dependent protein kinase II (CaM-kinase II) activity, and [125I]calmodulin binding to CaM-kinase II in DFP-treated hen brain supern...

journal_title：Neurochemical research

authors： Gupta RP,Abou-Donia MB

更新日期：1993-03-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39. Initially projected as a neuron-specific kinase, cdk5 is expressed ubiquitously and its kinase activity solely depends on the presence of its activators, which are al...

journal_title：Neurochemical research

authors： Kanungo J,Zheng YL,Mishra B,Pant HC

更新日期：2009-06-01 00:00:00

abstract：:The 7S NGF complex from the male mouse submaxillary gland consists of the alpha, gamma, and beta subunits in the ratio alpha 2 gamma 2 beta. The beta (NGF) subunit contains all the known biolocial activity of 7S NGF. The alpha and gamma subunits are both members of glandular kallikrein gene family, yet only gamma subu...

journal_title：Neurochemical research

authors： Burcham TS,Sim I,Bolin LM,Shooter EM

更新日期：1991-06-01 00:00:00