Abstract：
:The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacrylamide gel electrophoresis and computerized quantitation. Experiments were done on three groups of eggs: control group was incubated in the dark; simultaneously, in the same incubator, one group of eggs was illuminated by constant light, another by intermittent light (3 sec interval) from day 10 to day 16 of incubation. In embryos exposed to intermittent light the relative amount of tubulins was significantly increased in the optic lobe. In the frontal lobe no effect of light exposure on the concentration of tubulins was seen. The rise of tubulins in the optic lobe was only caused by intermittent light. Continuous illumination of the eggs for the same period under otherwise identical incubation conditions was ineffective.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Zhang J,Huether G,Neuhoff Vdoi
10.1007/BF00993240subject
Has Abstractpub_date
1987-04-01 00:00:00pages
331-4issue
4eissn
0364-3190issn
1573-6903journal_volume
12pub_type
杂志文章abstract：:Unrelated cells such as dental follicle precursor cells (DFPCs) and retinal Müller cells (MCs) make spheres after cultivation in serum-replacement medium (SRM). Until today, the relation and molecular processes of sphere formation from different cell types remain undescribed. Thus in this study we compared proteomes o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0524-0
更新日期：2011-11-01 00:00:00
abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1783-y
更新日期：2016-05-01 00:00:00
abstract：:During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering multiple cellular responses to injury. Here, we evaluated changes in extracellular ATP, ADP and AMP hydrolysis at different times (0-24 hours) after unilateral cortical stab injury (CSI) in adul...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9529-0
更新日期：2008-05-01 00:00:00
abstract：:The three essential amino acids, valine, leucine and isoleucine, constitute the group of branched-chain amino acids (BCAAs). BCAAs are rapidly taken up into the brain parenchyma, where they serve several distinct functions including that as fuel material in brain energy metabolism. As one function of astrocytes is con...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9895-2
更新日期：2009-07-01 00:00:00
abstract：:Omega-conotoxin GVIA (omega-CTX), as a selective blocker for an N-type Ca2+ channel, has been conveniently used in many molecular biochemical and pharmacological experiments. There has been little elucidation of 125I-omega-CTX binding sites (mainly the 135-kDa band) in the crude membranes from chick brain, although th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022805615926
更新日期：2003-05-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0517-z
更新日期：2011-11-01 00:00:00
abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0203-6
更新日期：2010-09-01 00:00:00
abstract：:The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decrea...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973280
更新日期：1988-07-01 00:00:00
abstract：:The microdialysis technique was used to study the effect of nitric oxide synthase (NOS) activity on taurine release. Taurine release was characterized in rat striatum that was excitotoxically lesioned compared to normal conditions. The basal taurine level of the dialysate decreased during quinolinate (QUIN) lesion in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022418231496
更新日期：1998-04-01 00:00:00
abstract：:Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and hu...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966825
更新日期：1992-10-01 00:00:00
abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995378
更新日期：1995-10-01 00:00:00
abstract：:Niemann-Pick disease type C (NPC) is a neurovisceral disorder characterized by lysosomal sequestration of endocytosed LDL-cholesterol, premature and abnormal enrichment of cholesterol in trans Golgi cisternae and accompanying anomalies in intracellular sterol trafficking. In addition to cholesterol, the NPC lesion has...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022575511354
更新日期：1999-04-01 00:00:00
abstract：:Diisopropyl phosphorofluoridate (DFP) produces type I organophosphorus ester-induced delayed neurotoxicity in humans and sensitive animal species. This is accompanied by enhanced Ca2+/CaM-dependent protein kinase II (CaM-kinase II) activity, and [125I]calmodulin binding to CaM-kinase II in DFP-treated hen brain supern...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969081
更新日期：1993-03-01 00:00:00
abstract：:It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-1826-2
更新日期：1999-02-01 00:00:00
abstract：:Using the replication-defective adenovirus vector, we overexpressed rat glia maturation factor (GMF) in primary astrocyte cultures derived from embryonic rat brains. Among the three isoforms of MAP kinase, there was a big increase in the phosphorylation of p38, as detected with Western blotting using the phosphospecif...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1014241300179
更新日期：2001-12-01 00:00:00
abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02929-8
更新日期：2020-02-01 00:00:00
abstract：:The frontal cortex, hippocampus, and cerebellum of the Fischer 344 rat were examined for an age-dependent change in neuronal and non-neuronal binding. Clonazepam and Ro5-6669 displaceable [3H]diazepam binding were used as indicators of [3H]diazepam binding on neuronal and non-neuronal membranes, respectively. In both ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964927
更新日期：1983-09-01 00:00:00
abstract：:We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection. The impulse activity flow of interneurons (IN) and motoneurons (MN) on stimulation of mixed (n. ischiad...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-2685-1
更新日期：2005-04-01 00:00:00
abstract：:We have synthesized the tertiary amines of pyridostigmine and neostigmine, 3-pyridinol dimethylcarbamate (norpyridostigmine) and 3-dimethylaminophenol dimethylcarbamate (norneostigmine) respectively, and we have tested their abilities to cross the blood-brain barrier and inhibit mouse brain AChE activity. The in vivo ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973747
更新日期：1990-06-01 00:00:00
abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1024280429036
更新日期：2003-08-01 00:00:00
abstract：:Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01000241
更新日期：1987-06-01 00:00:00
abstract：:Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1360-9
更新日期：2014-09-01 00:00:00
abstract：:Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-019-02753-0
更新日期：2020-03-01 00:00:00
abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970527
更新日期：1987-08-01 00:00:00
abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965151
更新日期：1994-09-01 00:00:00
abstract：:The effect of postdecapitative ischemia (5 min at 37 degrees) and hypoxia (5% O2, 95% N2, 30 min) on the distribution of protein radioactivity in the cellular fractions of guinea pig cerebral cortex was studied. Ischemic conditions resulted in the increase of total radioactivity level and protein content in the mitoch...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963828
更新日期：1979-02-01 00:00:00
abstract：:The enzymes degrading leucine enkephalin in human plasma and the inhibitors active on these enzymes were studied by kinetic and chromatographic techniques. Data obtained evidence the existence of complex kinetics of leu-enkephalin hydrolysis and of formation of its hydrolysis by-products. These appear to originate fro...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995551
更新日期：1995-09-01 00:00:00
abstract：:In order to develop a simplified method for long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density (10(3) cells/cm(2)), we optimized and modified conventional culturing methods. The modifications of our simplified method include: (1) combinational application of two growth substrates...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0189-0
更新日期：2010-09-01 00:00:00
abstract：:Acrylamide, a prototype neurotoxin, alters neurofilament protein (NF) gene expression in rat brain. Levels of mRNA coding for neurofilament protein subunits NF-L, NF-M, and NF-H have been determined by Northern blot analysis using 32P-labeled cDNA probes. Acrylamide given acutely (100 mg/kg, single intraperitoneal inj...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967449
更新日期：1994-07-01 00:00:00
abstract：:The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-011-0680-2
更新日期：2012-04-01 00:00:00
