Abstract:
:Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema may play a role in later brain damage. However, H2O intoxication, causing much greater generalized edema than the kainic acid-induced seizures, caused no necrotic edema in temporal cortex or hippocampus at 48 hr. Thus it appears that mannitol protection against kainic acid-induced brain damage may be by a mechanism in addition to dehydration.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Nelson SR,Olson JPdoi
10.1007/BF01000241subject
Has Abstractpub_date
1987-06-01 00:00:00pages
561-4issue
6eissn
0364-3190issn
1573-6903journal_volume
12pub_type
杂志文章abstract::Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...
journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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更新日期:2020-02-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:1989-12-01 00:00:00
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journal_title:Neurochemical research
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