Effect of aging on the rate of axonal transport of choline-phosphoglycerides.

abstract：:This study was designed to investigate the effects of chronic toluene inhalation in high concentration on lipid peroxidation, antioxidant enzyme activities and ultrastructural changes in the sciatic nerves of rats. Male Wistar albino rats (150-250 g) were divided in two experimental groups: the control and the toluene...

journal_title：Neurochemical research

authors： Coskun O,Oter S,Korkmaz A,Armutcu F,Kanter M

更新日期：2005-01-01 00:00:00

abstract：:The concentrations of dopamine (DA), 5-hydroxytryptamine (5-HT) and noradrenaline (NA) in the rat vas deferens divided in eight or four sections were determined by high performance liquid chromatography with electrochemical detection. Dopamine and NA had the same regional distribution; their concentrations were maxima...

journal_title：Neurochemical research

authors： Celuch SM,Sloley BD

更新日期：1988-10-01 00:00:00

abstract：:Despite the consensus that activation of TWIK-related spinal cord K+ (TRESK) might contribute to the pathogenesis of chronic pain, the specific mechanisms underlying the transfer and development of pain signals still remain obscure. In the present study, we validated that TRESK was expressed in neurons instead of glia...

journal_title：Neurochemical research

authors： Zhou J,Chen H,Yang C,Zhong J,He W,Xiong Q

更新日期：2017-05-01 00:00:00

abstract：:The number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the spinal dorsal horn evoked by noxious stimulation was previously shown to be increased following peripheral nerve injury, and this increase was proposed to reflect the neuropathic pain state. The aim of this study was to investigate whether anoma...

journal_title：Neurochemical research

authors： Terayama R,Kishimoto N,Yamamoto Y,Maruhama K,Tsuchiya H,Mizutani M,Iida S,Sugimoto T

更新日期：2015-03-01 00:00:00

abstract：:Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...

journal_title：Neurochemical research

authors： Brown TL,Macklin WB

更新日期：2020-03-01 00:00:00

abstract：:It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...

journal_title：Neurochemical research

authors： Potapenko E,Kostyuk E,Voitenko N,Kostyuk P

更新日期：2004-09-01 00:00:00

abstract：:The effect of the calcium channel blocker (KB-2796) on metabolic and functional recovery in rabbit spinal cord after 20, 30, and 40 min ischemia and 4 days of recovery was investigated. The drug was given intraperitoneally in three different doses, 10, 20, or 50 mg/kg pre- or post-ischemia of 20, 30, or 40 min duratio...

journal_title：Neurochemical research

authors： Danielisova V,Chavko M

更新日期：1994-12-01 00:00:00

abstract：:The study aimed to directly measure in vivo superoxide radical (O*2) a direct indicator of oxidative stress, in the brain of rats with experimentally induced obstructive jaundice by employing a new quantitative ultrasensitive fluorescent assay requiring minimum sample. O*2 anion is specific for dihydroethidine (DHE) a...

journal_title：Neurochemical research

authors： Konstantinou D,Mavrakis A,Grintzalis K,Papapostolou I,Assimakopoulos SF,Chroni E,Georgiou C

更新日期：2008-06-01 00:00:00

abstract：:Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...

journal_title：Neurochemical research

authors： Mercier MS,Lodge D

更新日期：2014-10-01 00:00:00

abstract：:Selective and limited proteolysis is a key step in the post-translational modification of peptide hormone precursors. This process appears to involve a proteolytic machinery including highly specific endoproteases. Some of the enzyme systems possibly involved in the processing of pro-neuropeptides will be described an...

journal_title：Neurochemical research

authors： Gluschankof P,Cohen P

更新日期：1987-10-01 00:00:00

abstract：:Neuropeptides are derived from large and inactive proteins which require endoproteolytic processing for the biosynthesis of the bioactive peptides. The maturation of pro-neuropeptide to neuropeptide is believed to be performed by ortholog pro-protein convertase EGL-3 in Caenorhabditis elegans (C. elegans). Furthermore...

journal_title：Neurochemical research

authors： Salem JB,Nkambeu B,Arvanitis DN,Beaudry F

更新日期：2018-11-01 00:00:00

abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...

journal_title：Neurochemical research

authors： Zirrgiebel U,Lindholm D

更新日期：1996-07-01 00:00:00

abstract：:Recent evidence indicates that mechanisms involved in reward and mechanisms involved in learning interact, in that reward includes learning processes and learning includes reward processes. In spite of such interactions, reward and learning represent distinct functions. In the present study, as part of an examination ...

journal_title：Neurochemical research

authors： Fallon S,Shearman E,Sershen H,Lajtha A

更新日期：2007-10-01 00:00:00

abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...

journal_title：Neurochemical research

authors： Cushman JD,Moore MD,Olsen RW,Fanselow MS

更新日期：2014-06-01 00:00:00

abstract：:In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered pr...

journal_title：Neurochemical research

authors： Aksenov MY,Tucker HM,Nair P,Aksenova MV,Butterfield DA,Estus S,Markesbery WR

更新日期：1999-06-01 00:00:00

abstract：:The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations...

journal_title：Neurochemical research

authors： Corvino V,Marchese E,Michetti F,Geloso MC

更新日期：2013-02-01 00:00:00

abstract：:The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when admi...

journal_title：Neurochemical research

authors： Stefanovich V

更新日期：1979-10-01 00:00:00

abstract：:Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is recovered as the free aminoacid within...

journal_title：Neurochemical research

authors： Mosnaim AD,Nguyen TD,Tse R,Puente J,Couceyro P,Wolf ME

更新日期：2008-01-01 00:00:00

abstract：:VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors an...

journal_title：Neurochemical research

authors： Mizoguchi T,Shimazawa M,Ohuchi K,Kuse Y,Nakamura S,Hara H

更新日期：2019-02-01 00:00:00

abstract：:The copper-transporting ATPases Atp7A and Atp7B play a major role in controlling intracellular copper levels. In addition, they are believed to deliver copper to the copper-requiring proteins destined for the secretory vesicles. One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepin...

journal_title：Neurochemical research

authors： Gerbasi V,Lutsenko S,Lewis EJ

更新日期：2003-06-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...

journal_title：Neurochemical research

authors： Yamada D,Fujikawa K,Kawabe K,Furuta T,Nakada M,Takarada T

更新日期：2018-11-01 00:00:00

abstract：:N-terminal protein arginylation has been demonstrated in vitro and in situ and has been reported to increase following injury to sciatic nerves of rats. The present study attempts to demonstrate these reactions in vivo by applying [3H]Arg to the cut end of sciatic nerves in anesthetized rats and assaying for N-termina...

journal_title：Neurochemical research

authors： Wang YM,Ingoglia NA

更新日期：1997-12-01 00:00:00

abstract：:Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...

journal_title：Neurochemical research

authors： Sámano C,Nistri A

更新日期：2019-01-01 00:00:00

abstract：:A double ligand enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against brain tissue antigens in the sera of patients with neurological diseases. The sera were tested on human white matter homogenate. The technique consists of successive incubations with the human serum to be tested, ...

journal_title：Neurochemical research

authors： Bologa L,Hofstetter W,Schonenberger K,Jacque C,Herschkowitz N

更新日期：1985-04-01 00:00:00

abstract：:SENP3 (SUMO-specific proteases 3), a member of the small ubiquitin-like modifier specific protease family, was identified as a molecule that deconjugates SUMOylation of modified protein substrates and functions as an isopeptidase by disrupting SUMO homeostasis to facilitate cancer development and progression. However,...

journal_title：Neurochemical research

authors： Wei H,Teng H,Huan W,Zhang S,Fu H,Chen F,Wang J,Wu C,Zhao J

更新日期：2012-12-01 00:00:00

abstract：:Aliskiren (ALK), a pharmacological renin inhibitor, is an effective antihypertensive drug and has potent anti-apoptotic activity, but it is currently unknown whether ALK is able to attenuate brain damage caused by acute cerebral ischemia independent of its blood pressure-lowering effects. This study aimed to investiga...

journal_title：Neurochemical research

authors： Miao J,Wang L,Zhang X,Zhu C,Cui L,Ji H,Liu Y,Wang X

更新日期：2016-09-01 00:00:00

abstract：:Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...

journal_title：Neurochemical research

authors： Neidle A,Manigault I,Wajda IJ

更新日期：1979-06-01 00:00:00

abstract：:We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...

journal_title：Neurochemical research

authors： Pilachowski J,Guilarte TR

更新日期：1993-12-01 00:00:00

abstract：:Pyroptosis is a newly identified lytic form of programmed cell death which is characterized by plasma membrane blebbing and rupture. Pyroptosis occurs in cerebral ischemia injury, and contributes to the activation and secretion of the inflammatory cytokines interleukin (IL)-1β, IL-18, and IL-6. Previous reports have f...

journal_title：Neurochemical research

authors： Liu D,Dong Z,Xiang F,Liu H,Wang Y,Wang Q,Rao J

更新日期：2020-02-01 00:00:00

abstract：:Staurosporine was found to bring about complete growth inhibition of human glioma cell lines. U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine tre...

journal_title：Neurochemical research

authors： Harmalkar MN,Shirsat NV

更新日期：2006-05-01 00:00:00