KB-2796, a calcium channel blocker, ameliorates ischemic spinal cord damage in rabbits.

abstract：:In the experimental setting, taurine is known to be released from swollen cells to reestablish their normal volume. However, its clinical relevance has not been fully understood. This study was undertaken to reveal changes in cerebrospinal fluid (CSF) amino acids concentration in patients with severe traumatic brain i...

journal_title：Neurochemical research

authors： Seki Y,Kimura M,Mizutani N,Fujita M,Aimi Y,Suzuki Y

更新日期：2005-01-01 00:00:00

abstract：:Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-b...

journal_title：Neurochemical research

authors： Nakanishi K,Tokita Y,Aono S,Ida M,Matsui F,Higashi Y,Oohira A

更新日期：2010-08-01 00:00:00

abstract：:Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema ...

journal_title：Neurochemical research

authors： Nelson SR,Olson JP

更新日期：1987-06-01 00:00:00

abstract：:In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawle...

journal_title：Neurochemical research

authors： Yildirim M,Aydin-Abidin S,Abidin I,Akca M,Canpolat S,Cansu A

更新日期：2013-08-01 00:00:00

abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...

journal_title：Neurochemical research

authors： Shen Y,Zhao H,Li P,Peng Y,Cui P,Miao F,Zhang Y,Zhang A,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrea...

journal_title：Neurochemical research

authors： Strosznajder J,Sun GY

更新日期：1981-07-01 00:00:00

abstract：:The objective of the present study was to investigate the effects of senescence on the binding characteristics of muscarinic receptors by using [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) as ligands in young (3 months), middle-age (10 months) and old (24 months) male Fischer 344 rats. M...

journal_title：Neurochemical research

authors： Surichamorn W,Kim ON,Lee NH,Lai WS,el-Fakahany EE

更新日期：1988-12-01 00:00:00

abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...

journal_title：Neurochemical research

authors： Gonçalves C,Dos Santos DB,Portilho SS,Lopes MW,Ghizoni H,de Souza V,Mack JM,Naime AA,Dafre AL,de Souza Brocardo P,Prediger RD,Farina M

更新日期：2018-03-01 00:00:00

abstract：:Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...

journal_title：Neurochemical research

authors： Ma Y,Sun S,Zhang J,Chen Z,Guo F,Du Y,Zhang J

更新日期：2016-04-01 00:00:00

abstract：:Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity ca...

journal_title：Neurochemical research

authors： Liu H,Song Z,Liao D,Zhang T,Liu F,Zhuang K,Luo K,Yang L

更新日期：2015-01-01 00:00:00

abstract：:Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combust...

journal_title：Neurochemical research

authors： Zahra J,Iqbal S,Zahra K,Javed Z,Shad MA,Akbar A,Ashiq MN,Iqbal F

更新日期：2017-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...

journal_title：Neurochemical research

authors： Yang J,Dombrowski SM,Deshpande A,Krajcir N,El-Khoury S,Krishnan C,Luciano MG

更新日期：2011-11-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) and Schwann cells (SCs) are closely-related cell types with regeneration-promoting properties. Comparative gene expression analysis is particularly relevant since it may explain cell type-specific effects and guide the use of each cell type into special clinical applications. In the ...

journal_title：Neurochemical research

authors： Omar M,Hansmann F,Kreutzer R,Kreutzer M,Brandes G,Wewetzer K

更新日期：2013-05-01 00:00:00

abstract：:The abnormal function of the voltage-gated potassium channel Kv10.2 can induce epilepsy. However, the physiological function of Kv10.2 in the central nervous system remains unclear. In this study, we found that Kv10.2 knockout (KO) increased the complexity of neurons in the CA3 subarea of hippocampus. Kv10.2 KO led to...

journal_title：Neurochemical research

authors： Liu Y,Tang Y,Yan J,Du D,Yang Y,Chen F

更新日期：2020-12-01 00:00:00

abstract：:Disruptive effects of calcium upon neurofilaments and glial filaments were studied in white matter of rat optic nerve and spinal cord and in rat peripheral nerve. Filament ultrastructure and tissue protein composition were compared following a calcium influx into excised tissues. A calcium influx was induced by freeze...

journal_title：Neurochemical research

authors： Schlaepfer WW,Zimmerman UP

更新日期：1981-03-01 00:00:00

abstract：:Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, sing...

journal_title：Neurochemical research

authors： Choi S,DiSilvio B,Fernstrom MH,Fernstrom JD

更新日期：2011-03-01 00:00:00

abstract：:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

journal_title：Neurochemical research

authors： Florian CL,Williams SR,Bhakoo KK,Noble MD

更新日期：1996-09-01 00:00:00

abstract：:The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and i...

journal_title：Neurochemical research

authors： Morrison RS,Kinoshita Y,Johnson MD,Guo W,Garden GA

更新日期：2003-01-01 00:00:00

abstract：:In the present study mitochondrial respiratory function of fibroblasts from a patient affected by early-onset parkinsonism carrying the homozygous W437X nonsense mutation in the PINK1 gene has been thoroughly characterized. When compared with normal fibroblasts, the patient's fibroblast mitochondria exhibited a lower ...

journal_title：Neurochemical research

authors： Piccoli C,Sardanelli A,Scrima R,Ripoli M,Quarato G,D'Aprile A,Bellomo F,Scacco S,De Michele G,Filla A,Iuso A,Boffoli D,Capitanio N,Papa S

更新日期：2008-12-01 00:00:00

abstract：:The influence of phosphatidylserine (PS) on the isoniazid-induced convulsions has been studied in mice. Sonicated dispersions of this phospholipid given intravenously do not show anticonvulsant activity but they do so when gamma-aminobutyric acid (GABA) is simultaneously injected. GABA alone is inactive. The synergism...

journal_title：Neurochemical research

authors： Toffano G,Mazzari S,Zanotti A,Bruni A

更新日期：1984-08-01 00:00:00

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00

abstract：:Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports i...

journal_title：Neurochemical research

authors： de Oliveira MR

更新日期：2016-06-01 00:00:00

abstract：:Glucocorticoid receptors (GRs) exert actions on the hippocampus that are important for memory formation. There are correlations between vascular dysfunctions and GR-related gene expression. Both vascular dysfunction and GR gene expression decline occur during the ageing process. Therefore, hypotensors, which have effe...

journal_title：Neurochemical research

authors： Li X,Ma J,Xu J,Zhu D,Li A,Che Y,Chen D,Feng X

更新日期：2017-11-01 00:00:00

abstract：:To assess RNAi mediated inhibition of the expression of wt-DYT1 on H(2)O(2)-induced toxicity in NIH 3T3 cells and primary cortical neurons. To detect the function of wild-type Torsin A and the effect of SiRNA on the wt-DYT1 gene. The shRNA expression vector was constructed by ligating annealed complementary shRNA olig...

journal_title：Neurochemical research

authors： Chen XP,Hu XH,Wu SH,Zhang YW,Xiao B,Shang HF

更新日期：2010-08-01 00:00:00

abstract：:The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...

journal_title：Neurochemical research

authors： Dewar KM,Dyck LE,Durden DA,Boulton AA

更新日期：1988-02-01 00:00:00

abstract：:The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...

journal_title：Neurochemical research

authors： Miyaoka T,Kimura T,Saunders PA,Tseng YT,Ho IK

更新日期：1994-01-01 00:00:00

abstract：:An in vitro model of anoxia-induced brain damage was utilized to help elucidate the biochemical basis of cell damage due to reduced oxygen availability. Previous studies suggest that anoxia-induced damage may vary presynaptically, post-synaptically or in the cell body. Thus, the consequences of an anoxic treatment inc...

journal_title：Neurochemical research

authors： Gibson GE,Freeman GB,Mykytyn V

更新日期：1988-04-01 00:00:00

abstract：:Pyridostigmine bromide (PB), an inhibitor of acetylcholinesterase, has been used as a prophylactic for nerve gas poisoning. N,N'-diethyl-m-toluamide (DEET) is the active ingredient in most insect repellents and is thought to interact synergistically with PB. Since PB can inhibit the binding of organophosphates to tubu...

journal_title：Neurochemical research

authors： Prasad V,Scotch R,Chaudhuri AR,Walss C,Fathy DB,Miller C,Ludueña RF

更新日期：2000-01-01 00:00:00

abstract：:Single prolonged stress (SPS) rats is a rodent model of post traumatic stress disorder (PTSD). Abnormal hippocampal morphology and function were found in the PTSD patients. Our previous study has shown that SPS induce loss of hippocampal neurons. But the effects of SPS on glial cells in the hippocampus have not been e...

journal_title：Neurochemical research

authors： Han F,Xiao B,Wen L

更新日期：2015-05-01 00:00:00

abstract：:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...

journal_title：Neurochemical research

authors： Blagova OE,Budantsev AY,Sytinsky IA,Lajtha A

更新日期：1982-11-01 00:00:00