Abstract:
:Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-band protein recognized by an anti-pleiotrophin antibody. The binding of pleiotrophin (PTN) to NGC was confirmed by a quartz crystal microbalance method and had a Kd of 8.7 nM. PTN bound to the acidic amino acid cluster of the NGC extracellular domain. In addition, PTN bound to both chondroitin sulfate-bearing NGC and chondroitinase-treated NGC prepared from the neonatal rat brain. These results suggest that NGC interacts with PTN.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Nakanishi K,Tokita Y,Aono S,Ida M,Matsui F,Higashi Y,Oohira Adoi
10.1007/s11064-010-0164-9subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1131-7issue
8eissn
0364-3190issn
1573-6903journal_volume
35pub_type
杂志文章abstract::Rett syndrome (RS) is an X-linked neurodevelopmental disorder mostly involving mutations in the gene for methyl-CpG-binding protein 2 (MECP2). Ganglioside abnormalities were previously found in cerebrum and cerebellum in RS patients. We evaluated total lipid distribution in cerebrum/brainstem, hippocampus, and cerebel...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9874-7
更新日期:2009-06-01 00:00:00
abstract::1-Methyl-4-phenylpyridinium (MPP(+)) or 6-hydroxydopamine (6-OHDA) caused a nuclear damage, the mitochondrial membrane permeability changes, leading to the cytochrome c release and caspase-3 activation, the formation of reactive oxygen species and the depletion of GSH in PC12 cells. Nicardipine (a calcium channel bloc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9088-9
更新日期:2006-07-01 00:00:00
abstract::Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by D: -amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of Parkinson's disease. To examine if the neuroprotecti...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9253-1
更新日期:2007-07-01 00:00:00
abstract::The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2544-5
更新日期:2018-06-01 00:00:00
abstract::We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory. Although it has been shown that mGlu5 signalling is required for certain forms of learning and memory, its role in spatial learning is unclear since studies using pharmacological or knockout mice models provid...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1595-0
更新日期:2015-06-01 00:00:00
abstract::Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1840-1
更新日期:2016-06-01 00:00:00
abstract::Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965929
更新日期:1989-10-01 00:00:00
abstract::Aging is accompanied by the loss of memory and cognitive functions. The extracellular signal-regulated kinase (ERK) pathway has been shown to play an essential role in synaptic plasticity and memory. Although a reduction in basal ERK1/2 activity has been found in the cerebral cortex in aged rats, changes in ERK1/2 mRN...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1024948532633
更新日期:2003-09-01 00:00:00
abstract::This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9661-5
更新日期:2008-09-01 00:00:00
abstract::The carnitine/acylcarnitine transporter is a transport system whose function is essential for the mitochondrial β-oxidation of fatty acids. Here, the presence of carnitine/acylcarnitine carrier (CACT) in nervous tissue and its sub-cellular localization in dorsal root ganglia (DRG) neurons have been investigated. Weste...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1168-z
更新日期:2013-12-01 00:00:00
abstract::The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the phar...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02532381
更新日期:1996-11-01 00:00:00
abstract::Endoplasmic reticulum (ER) and mitochondria are intracellular organelles and their interactions are directly involved in different processes such as Ca(2+) signaling in cell survival and death mechanisms. Bcl-2 is an anti-apoptotic protein intrinsically related to ER and mitochondria, modulating Ca(2+) content in thes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0600-5
更新日期:2012-02-01 00:00:00
abstract::S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9915-x
更新日期:2009-08-01 00:00:00
abstract::Isorhynchophylline (IRN), an oxindole alkaloid, has been identified as the main active ingredient responsible for the biological activities of Uncaria rhynchophylla (Miq) Miq ex Havil. (Rubiaceae). Previous studies in our laboratory have revealed that IRN possesses potent neuroprotective effects in different models of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2124-5
更新日期:2017-02-01 00:00:00
abstract::Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02728-1
更新日期:2019-04-01 00:00:00
abstract::To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2580-1
更新日期:2018-08-01 00:00:00
abstract::Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964846
更新日期:1985-09-01 00:00:00
abstract::Carp (Cyprinus carpio L.) whole brain was used to investigate the thermal acclimation changes under normoxic conditions of three-subclasses (alkenylacyl-, alkylacyl- and diacyl-subclasses) of choline glycerophospholipids (CGP), ethanolamine glycerophospholipids (EGP) and inositol glycerophospholipids (IGP) as well as ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021937114401
更新日期:1997-10-01 00:00:00
abstract::The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and the NADPH-diaphoras...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020918310281
更新日期:1999-01-01 00:00:00
abstract::Cholinergic muscarinic receptors, when stimulated by arecoline, can activate cytosolic phospholipase A(2) (cPLA(2)) to release arachidonic acid (AA) from membrane phospholipid. This signal can be imaged in the brain in vivo using quantitative autoradiography following the intravenous injection of radiolabeled AA, as a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9372-3
更新日期:2007-11-01 00:00:00
abstract::Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1965-2
更新日期:2016-10-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a degenerative disorder caused by motor neuron loss. T-cell intracellular antigen-1 (TIA-1), a cytotoxic T lymphocyte granule-associated RNA binding protein, is a key component of stress granules. However, it remains uncertain whether ALS-causing superoxide dismutase-1 (SOD1) tox...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03137-5
更新日期:2020-12-01 00:00:00
abstract::Proteolipid protein (PLP) is the major intrinsic membrane protein of CNS myelin and is expressed in oligodendrocytes as part of a coordinate program of myelin-specific gene activation. In order to identify the DNA sequences and proteins involved in the regulation of PLP transcription, we have analyzed the 5' flanking ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968716
更新日期:1994-08-01 00:00:00
abstract::Postmortem changes in the activity of GDH, GAD, GABA-T, and GS in the adult forebrain and cerebellum and in the forebrain of newborns have been investigated. The activities of GDH, GAD, and GS were stable till 12 hr after death in both adult and young brain regions studied. The activity of GABA-T was stable till 30 mi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966226
更新日期:1986-10-01 00:00:00
abstract::The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-009-9922-y
更新日期:2009-04-01 00:00:00
abstract::We studied the dose-response characteristics and the temporal profile of inhibition of brain nitric oxide (NO) synthase (NOS) elicited by i.v. administration of the NOS inhibitor nitro-L-arginine methyl ester (L-NAME). L-NAME was administered i.v. in awake rats equipped with a venous cannula. L-NAME was injected in cu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967330
更新日期:1994-04-01 00:00:00
abstract::Niemann-Pick disease type C (NPC) is a neurovisceral disorder characterized by lysosomal sequestration of endocytosed LDL-cholesterol, premature and abnormal enrichment of cholesterol in trans Golgi cisternae and accompanying anomalies in intracellular sterol trafficking. In addition to cholesterol, the NPC lesion has...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022575511354
更新日期:1999-04-01 00:00:00
abstract::The neuropathy associated with diabetes includes well documented impairment of axonal transport, a reduction in axon calibre and a reduced capacity for nerve regeneration. All of those aspects of nerve function rely on the integrity of the axonal cytoskeleton. Alterations in the axonal cytoskeleton in experimental dia...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022466624223
更新日期:1997-08-01 00:00:00
abstract::gamma-L-Glutamylglutamate (LGG), an endogenous constituent of the brain, reduced the glutamate-evoked increase in intracellular Ca2+ in cultured cerebellar granule cells. The extent and properties of this inhibition were different at different Mg2+ concentrations. The intracellular Ca2+ response to NMDA was slightly e...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970596
更新日期:1995-12-01 00:00:00
abstract::The effects of the following drugs: nimodipine (1 mg/kg b.w., i.p.), 2-amino-5-phosphonovaleric acid (4 mg/kg b.w., i.p.) and propentofylline (25 mg/kg b.w., i.p.), administered (alone or in combination) at the end of 15 min bilateral ischemia in gerbils were evaluated on mitochondrial superoxide dismutase (SOD), glut...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966815
更新日期:1994-02-01 00:00:00