Abstract:
:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication of animals, relative stabilization of the electrophysiological indices of the rat brain activity was observed. This reflects the CNS adaptation to the constant ethanol presence in the blood. This state was also characterized by the relative stabilization of the serotonin system and by the increase of the catecholamine level. Withdrawal of ethanol after prolonged consumption caused accumulation of catecholamines in rat brain, depletion of serotonin and GABA, and increased excitability of the nervous structures. The changes of activity of the GABA- and monoaminergic systems are coupled to manifestation of symptoms of alcohol depression and convulsive reactions during ethanol withdrawal.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Blagova OE,Budantsev AY,Sytinsky IA,Lajtha Adoi
10.1007/BF00966062subject
Has Abstractpub_date
1982-11-01 00:00:00pages
1335-45issue
11eissn
0364-3190issn
1573-6903journal_volume
7pub_type
杂志文章abstract::Zonisamide (ZNS), an antiepileptic drug having beneficial effects also against Parkinson's disease symptoms, has proven to display an antioxidant effects in different experimental models. In the present study, the effects of ZNS on rotenone-induced cell injury were investigated in human neuroblastoma SH-SY5Y cells dif...
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
abstract::We previously showed that extracellular levels of N-acetylaspartate (NAA) increase when a medium with reduced NaCl concentration is perfused through a microdialysis probe, and proposed that NAA may be released during hypoosmotic swelling. Here, we demonstrate that this effect is due to hypoosmolarity of the perfusion ...
journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
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