Characterization of endogenous amino acid efflux from hippocampal slices during chemically-induced ischemia.

abstract：:The axonal transport of tRNA has been investigated in the chick optic system. Chicks were injected with [3H]uridine intraocularly or intracranially and the RNA of the retina, nerve complex, and tecta separated by polyacrylamide gel electrophoresis and then counted. The ratio of tRNA to rRNA specific activities increas...

journal_title：Neurochemical research

authors： Por S,Gunning PW,Jeffrey PL,Austin L

更新日期：1978-08-01 00:00:00

abstract：:Hemin is a breakdown product of the blood protein, hemoglobin and is responsible for much of the secondary damage caused following a hemorrhagic stroke. Hemin is toxic to cultured astrocytes and it is thought that this toxicity is due to iron that is liberated when hemin is degraded. However, free iron applied to astr...

journal_title：Neurochemical research

authors： Owen JE,Bishop GM,Robinson SR

更新日期：2016-02-01 00:00:00

abstract：:We observed that AP-3, an antagonist of metabotropic glutamate receptors, reduced carbachol-induced hydrolysis of phospholipids in hippocampal slices. This inhibition could be explained in different ways, e.g.: 1) AP-3 acts also as antagonist of muscarinic receptors mediating the hydrolysis of phospholipids induced by...

journal_title：Neurochemical research

authors： Llansola M,Hermenegildo C,Miñana MD,Felipo V

更新日期：1998-06-01 00:00:00

abstract：:Glutamine synthetase (GS) is the major glutamine-forming enzyme of vertebrates and is accepted to be a marker of astroglial cells. Maturation of astroglial cells is characterized by an increase of GS activity, and the regulation of this enzyme is the topic of many publications. Because of the fundamental role of the G...

journal_title：Neurochemical research

authors： Haghighat N

更新日期：2005-05-01 00:00:00

abstract：:Evidence that brain glutamatergic activity is pathologically elevated in bipolar disorder suggests that mood stabilizers are therapeutic in the disease in part by downregulating glutamatergic activity. Such activity can involve the second messenger, arachidonic acid (AA, 20:4n - 6). We tested this hypothesis with rega...

journal_title：Neurochemical research

authors： Basselin M,Chang L,Chen M,Bell JM,Rapoport SI

更新日期：2008-11-01 00:00:00

abstract：:Parecoxib is a recently described novel COX-2 inhibitor whose functional significance and neuroprotective mechanisms remain elusive. Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury vi...

journal_title：Neurochemical research

authors： Ye Z,Wang N,Xia P,Wang E,Yuan Y,Guo Q

更新日期：2012-02-01 00:00:00

abstract：:The specific molecular events that underlie the age-related loss of cognitive function are poorly understood. Although not experimentally substantiated, age-dependent neuronal loss has long been considered central to age-related cognitive decline. More recently, age-related changes in brain white matter have taken pre...

journal_title：Neurochemical research

authors： Hinman JD,Abraham CR

更新日期：2007-12-01 00:00:00

abstract：:Hippocampal cells dissociated from 5-day-old rat pups were grown in a suitable chemically defined basal medium, supplemented or not with 3,3',5-triiodo-L-thyronine (T3), [Arg8]-vasopressin (AVP), or both, at different concentrations. Four days after plating, neuron-like cells began to degenerate drastically in the bas...

journal_title：Neurochemical research

authors： Clos J,Gabrion J

更新日期：1989-10-01 00:00:00

abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....

journal_title：Neurochemical research

authors： Oishi K,Nakajima K

更新日期：2018-01-01 00:00:00

abstract：:Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...

journal_title：Neurochemical research

authors： Chen Z,Hu Q,Xie Q,Wu S,Pang Q,Liu M,Zhao Y,Tu F,Liu C,Chen X

更新日期：2019-04-01 00:00:00

abstract：:The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and -amino butyric acid (GABA) and expression of glial fibrillary acid protein (GFAP), vascular endothe...

journal_title：Neurochemical research

authors： Zeng K,Xu H,Mi M,Zhang Q,Zhang Y,Chen K,Chen F,Zhu J,Yu X

更新日期：2009-02-01 00:00:00

abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...

journal_title：Neurochemical research

authors： Grove J,Kentroti S,Prasad K,Vernadakis A

更新日期：1997-03-01 00:00:00

abstract：:Emerging data suggests that mitochondrial dysfunction is prominently involved in Alzheimer disease (AD) progression. Sirtuin-3 (Sirt3) is a member of the sirtuin family of nicotinamide adenine dinucleotide dependent deacetylases that regulates a variety of mitochondrial functions and suppresses mitochondria-related ph...

journal_title：Neurochemical research

authors： Yang W,Zou Y,Zhang M,Zhao N,Tian Q,Gu M,Liu W,Shi R,Lü Y,Yu W

更新日期：2015-08-01 00:00:00

abstract：:Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...

journal_title：Neurochemical research

authors： Thatcher NM,Badar-Goffer RS,Ben-Yoseph O,McLean MA,Morris PG,Prior MJ,Taylor A,Bachelard HS

更新日期：2002-02-01 00:00:00

abstract：:We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...

journal_title：Neurochemical research

authors： Simzar S,Ellyin R,Shau H,Sarafian TA

更新日期：2000-12-01 00:00:00

abstract：:Protein kinase C has recently attracted considerable attention because of its importance in the control of cell division, cell differentiation, and signal transduction across the cell membrane. The activity of this enzyme is altered by several lipids such as diacylglycerol, free fatty acids, lipoxins, gangliosides, an...

journal_title：Neurochemical research

authors： Farooqui AA,Farooqui T,Yates AJ,Horrocks LA

更新日期：1988-06-01 00:00:00

abstract：:A phosphoinositide-linked peptide response in cultured rat astrocytes was studied by measuring the accumulation of [3H]inositol phosphates in the presence of lithium. Cultures derived from cortex, cerebellum and spinal cord each showed a unique pattern or degree of stimulation to a panel of neuropeptides. Cortical and...

journal_title：Neurochemical research

authors： Cholewinski AJ,Hanley MR,Wilkin GP

更新日期：1988-04-01 00:00:00

abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...

journal_title：Neurochemical research

authors： Jiang F,Yin H,Qin X

更新日期：2012-09-01 00:00:00

abstract：:Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...

journal_title：Neurochemical research

authors： Maliszewski-Hall AM,Alexander M,Tkáč I,Öz G,Rao R

更新日期：2017-01-01 00:00:00

abstract：:The effect of hydrogen peroxide (H2O2) on cytosolic free calcium concentration ([Ca2+]c) as well as its effect on glutamate secretion in rat hippocampal astrocytes have been the aim of the present research. Our results show that 100 microM H2O2 induces an increase in [Ca2+]c, that remains at an elevated level while th...

journal_title：Neurochemical research

authors： González A,Granados MP,Pariente JA,Salido GM

更新日期：2006-06-01 00:00:00

abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...

journal_title：Neurochemical research

authors： Pei DS,Sun YF,Song YJ

更新日期：2009-08-01 00:00:00

abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...

journal_title：Neurochemical research

authors： Michaelis ML,Michaelis EK,Simpson AE

更新日期：1982-02-01 00:00:00

abstract：:Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5'-dithiobis-(2-nitrobenzoic acid); DTNB). It also is inhibited by the product GABA, many anions (e.g. SCN- and Cl-), and...

journal_title：Neurochemical research

authors： Grossfeld RM,Yancey SW,Baxter CF

更新日期：1984-07-01 00:00:00

abstract：:Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and cura...

journal_title：Neurochemical research

authors： Pagán OR,Montgomery E,Deats S,Bach D,Baker D

更新日期：2015-10-01 00:00:00

abstract：:MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...

journal_title：Neurochemical research

authors： Ji W,Jiao J,Cheng C,Shao J

更新日期：2018-10-01 00:00:00

abstract：:The mechanism of focal demyelination in multiple sclerosis has been a long-standing enigma of this disorder. Cytokines, a diverse family of signalling molecules, are viewed as potential mediators of the process based on clinical observations and studies with animal models and tissue/cell culture systems. Myelin and ol...

journal_title：Neurochemical research

authors： Ledeen RW,Chakraborty G

更新日期：1998-03-01 00:00:00

abstract：:The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems t...

journal_title：Neurochemical research

authors： Recasens M,Gabellec MM,Mack G,Mandel P

更新日期：1978-02-01 00:00:00

abstract：:Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine potentiating and possible neuroprotective properties it has an established role in the treatment of parkins...

journal_title：Neurochemical research

authors： Magyar K,Szende B,Jenei V,Tábi T,Pálfi M,Szöko E

更新日期：2010-12-01 00:00:00

abstract：:3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...

journal_title：Neurochemical research

authors： Tsang TM,Haselden JN,Holmes E

更新日期：2009-07-01 00:00:00

abstract：:Transgenic therapy for central neuralgia faces the problems of low expression and weak targeting and affects superficial but not deep neurons. In this study, we generated a lentivirus vector with human preproenkephalin gene (hPPE) expression driven by the transcriptional amplification strategy system (TAS) and establi...

journal_title：Neurochemical research

authors： Yang J,Zhang L,Xie P,Pan M,Ma G

更新日期：2020-09-01 00:00:00