What's behind the decline? The role of white matter in brain aging.

abstract：:Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals. It was found that adenosine...

journal_title：Neurochemical research

authors： Cunha RA

更新日期：2001-09-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood-brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a sub...

journal_title：Neurochemical research

authors： Yu Y,Fang H,Qiu Z,Xia Z,Zhou B

更新日期：2020-02-01 00:00:00

abstract：:Ménière's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on post-mortem examination. Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptot...

journal_title：Neurochemical research

authors： Calabrese V,Cornelius C,Maiolino L,Luca M,Chiaramonte R,Toscano MA,Serra A

更新日期：2010-12-01 00:00:00

abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...

journal_title：Neurochemical research

authors： Colwell CS,Ghiani CA

更新日期：2020-03-01 00:00:00

abstract：:Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three...

journal_title：Neurochemical research

authors： Simon JR,Oderfeld-Nowak B,Felten DL,Aprison MH

更新日期：1981-05-01 00:00:00

abstract：:The major breakthrough discovery of enkephalins as endogenous opiates led our attempts to determine their inactivation mechanisms. Because the NH2-terminal tyrosine is absolutely necessary for the neuropeptides to exert analgesic effects, and aminopeptidase activities are extraordinarily high in the brain, a specific ...

journal_title：Neurochemical research

authors： Hui KS

更新日期：2007-12-01 00:00:00

abstract：:We have attempted to show eventual modifications in the brain protein synthesis apparatus of rat during the first three weeks after birth. Through this time we noted a steady decrease (about 60%) in the free polysomes, when expressed relative to tissue weight. This decrease does not correlate with changes in the polys...

journal_title：Neurochemical research

authors： Gauthier D,Ven Murthy MR

更新日期：1986-09-01 00:00:00

abstract：:The standard ELISA technique was improved for the detection of antigalactocerebroside antibody in biological fluid. Mouse monoclonal antigalactocerebroside antibody was used to demonstrate specificity and sensitivity of the technique. After optimization of the assay, the usefulness of this measurement for the evaluati...

journal_title：Neurochemical research

authors： Ichioka T,Uobe K,Stoskopf M,Kishimoto Y,Tennekoon G,Tourtellotte WW

更新日期：1988-03-01 00:00:00

abstract：:To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI...

journal_title：Neurochemical research

authors： Xie W,Yang SY,Zhang Q,Zhou Y,Wang Y,Liu R,Wang W,Shi J,Ning B,Jia T

更新日期：2018-08-01 00:00:00

abstract：:Neurovascular injury comprises a wide spectrum of pathophysiology that underlies the progression of brain injury after cerebral ischemia. Recently, it has been shown that activation of the integrin-associated protein CD47 mediates the development of blood-brain barrier injury and edema after cerebral ischemia. However...

journal_title：Neurochemical research

authors： Xing C,Arai K,Park KP,Lo EH

更新日期：2010-07-01 00:00:00

abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...

journal_title：Neurochemical research

authors： Wang P,Liang X,Lu Y,Zhao X,Liang J

更新日期：2016-10-01 00:00:00

abstract：:Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...

journal_title：Neurochemical research

authors： Jacobs TQ,Passarello B,Horwitz J

更新日期：1998-08-01 00:00:00

abstract：:This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice ...

journal_title：Neurochemical research

authors： Huang XF,Yu Y,Li Y,Tim S,Deng C,Wang Q

更新日期：2008-09-01 00:00:00

abstract：:The metabolic effects of ganglioside GM1 were found to be quite different in brain synaptosomes and phagocytic cells. Incubation of rat brain cortex synaptosomes with GM1 was shown to decrease the production of reactive oxygen species induced by Fe2+-H2O2 system and measured by chemiluminometric method in the presence...

journal_title：Neurochemical research

authors： Avrova NF,Zakharova IO,Tyurin VA,Tyurina YY,Gamaley IA,Schepetkin IA

更新日期：2002-08-01 00:00:00

abstract：:The current study demonstrates that in hippocampal neurons mitochondrial Ca(2+) processing supports Ca(2+) influx via ionotropic glutamate (Glu) receptors. We define mitochondrial Ca(2+) processing as Ca(2+) uptake via mitochondrial Ca(2+) uniporter (MCU) combined with subsequent Ca(2+) release via mitochondrial Na(+)...

journal_title：Neurochemical research

authors： Strokin M,Reiser G

更新日期：2016-06-01 00:00:00

abstract：:Neuropeptides are derived from large and inactive proteins which require endoproteolytic processing for the biosynthesis of the bioactive peptides. The maturation of pro-neuropeptide to neuropeptide is believed to be performed by ortholog pro-protein convertase EGL-3 in Caenorhabditis elegans (C. elegans). Furthermore...

journal_title：Neurochemical research

authors： Salem JB,Nkambeu B,Arvanitis DN,Beaudry F

更新日期：2018-11-01 00:00:00

abstract：:Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug admi...

journal_title：Neurochemical research

authors： Hiramatsu M,Edamatsu R,Kabuto H,Higashihara Y,Mori A

更新日期：1989-01-01 00:00:00

abstract：:Astrocyte-neuron communication has recently been proposed as a potential mechanism participating to synaptic transmission. With the development of this concept and accumulating evidences in favor of a modulation of synaptic transmission by astrocytes, has emerged the term gliotransmission. It refers to the capacity of...

journal_title：Neurochemical research

authors： Ben Achour S,Pascual O

更新日期：2012-11-01 00:00:00

abstract：:Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...

journal_title：Neurochemical research

authors： Pastuszko P,Schears GJ,Greeley WJ,Kubin J,Wilson DF,Pastuszko A

更新日期：2014-11-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:Axonal regeneration across the site of spinal cord lesion is often aborted in adult mammalian species. The use of DNA vaccine to nullify the inhibitory molecules has been shown to be effective in promoting axonal regeneration in injured spinal cord. The possible molecular mechanisms, however, remain to be elucidated. ...

journal_title：Neurochemical research

authors： Zhang Y,Hao CG,Hu LQ,Dong J,Wei P,Xu D,Xiao ZC,Wang TH

更新日期：2009-09-01 00:00:00

abstract：:The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and i...

journal_title：Neurochemical research

authors： Morrison RS,Kinoshita Y,Johnson MD,Guo W,Garden GA

更新日期：2003-01-01 00:00:00

abstract：:We report here the isolation of fractions enriched in components of the myelin-like membranes surrounding the giant axons of the earthworm. Lumbricus terrestris L. The composition and purity of the fractions have been assessed using SDS-protein electrophoresis, Western immunoblots, and electron microscopy. Preliminary...

journal_title：Neurochemical research

authors： Pereyra PM,Roots BI

更新日期：1988-09-01 00:00:00

abstract：:Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...

journal_title：Neurochemical research

authors： Yuwiler A,Bennett BL,Geller E

更新日期：1982-10-01 00:00:00

abstract：:Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...

journal_title：Neurochemical research

authors： Henderson NS,Tweedle CD,Kabara JJ

更新日期：1980-12-01 00:00:00

abstract：:Insulin-like growth factor 1 (IGF-1) stimulates α-secretase processing of amyloid precursor protein (APP) and decreases Aβ production. Little is known about the relationship between IGF-1 and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1), the protease essential for the production of β-amyloid peptides (A...

journal_title：Neurochemical research

authors： Zhang H,Gao Y,Dai Z,Meng T,Tu S,Yan Y

更新日期：2011-01-01 00:00:00

abstract：:Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...

journal_title：Neurochemical research

authors： Seo JH,Chang JH,Song SH,Lee HN,Jeon GS,Kim DW,Chung CK,Cho SS

更新日期：2008-07-01 00:00:00

abstract：:The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrea...

journal_title：Neurochemical research

authors： Strosznajder J,Sun GY

更新日期：1981-07-01 00:00:00

abstract：:The effects of the following drugs: nimodipine (1 mg/kg b.w., i.p.), 2-amino-5-phosphonovaleric acid (4 mg/kg b.w., i.p.) and propentofylline (25 mg/kg b.w., i.p.), administered (alone or in combination) at the end of 15 min bilateral ischemia in gerbils were evaluated on mitochondrial superoxide dismutase (SOD), glut...

journal_title：Neurochemical research

authors： Stanimirovic DB,Micic DV,Markovic M,Spatz M,Mrsulja BB

更新日期：1994-02-01 00:00:00

abstract：:The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...

journal_title：Neurochemical research

authors： Yoshino Y

更新日期：1984-03-01 00:00:00