Recombinant DNA vaccine against inhibition of neurite outgrowth promotes functional recovery associated with endogeous NGF expression in spinal cord hemisected adult rats.

abstract：:This study evaluates whether physiological variables differentially affect the local synthesis of protein constituents of synapses in subcellular fractions containing pinched-off dendrites (synaptodendrosomes). Synaptodendrosomes were pulse-labeled in a medium containing 35S-methionine with 3 or 25 mM KCl and in the p...

journal_title：Neurochemical research

authors： Leski ML,Steward O

更新日期：1996-06-01 00:00:00

abstract：:The incorporation of [gamma-32P]ATP into proteins of rat brain polyribosomes was studied in vitro. The effects of cyclic nucleotides, calcium, hemin, ACTH, GTP, and spermine were examined. The incorporation of phosphate into proteins increased with time and phosphatase activity was very low; thus, the extent of phosph...

journal_title：Neurochemical research

authors： Schrama LH,Frankena H,Edwards PM,Schotman P

更新日期：1984-09-01 00:00:00

abstract：:The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal we...

journal_title：Neurochemical research

authors： Caliskan M,Mogulkoc R,Baltaci AK,Menevse E

更新日期：2016-07-01 00:00:00

abstract：:The Fatty Acid method was used to determine whether incorporation of plasma radiolabeled arachidonic acid into brain phospholipids is controlled by phospholipase A2. Awake rats received an i.v. injection of a phospholipase A2 inhibitor, manoalide (10 mg/kg), and then were infused i.v. with [1-(14)C]arachidonate or [3H...

journal_title：Neurochemical research

authors： Grange E,Rabin O,Bell J,Chang MC

更新日期：1998-10-01 00:00:00

abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...

journal_title：Neurochemical research

authors： Shukla PK,Khanna VK,Ali MM,Khan MY,Srimal RC

更新日期：2008-06-01 00:00:00

abstract：:The uptake of radioactive ethanolamine has been studied in exclusively neuronal and glial cell cultures from dissociated cerebral hemispheres of chick embryos. Both cell types show saturable kinetics; neurons have an apparent Km of 6.7 microM, Vmax 41.4 pmol mg prot.-1 min-1 and glial cells a Km of 119.6 microM, Vmax ...

journal_title：Neurochemical research

authors： Massarelli AC,Dainous F,Hoffmann D,Mykita S,Freysz L,Dreyfus H,Massarelli R

更新日期：1986-01-01 00:00:00

abstract：:Radioactive azide derivatives of tetrodotoxin (TTX) were synthesized using 2-nitro-4-azidephenyl-[3H]beta alanine for the purpose of photolabeling of the Na channel. Three azide derivatives, N1, N2 and N3, were separated by ion exchange chromatography on Bio-Rex 70 resin and reversed phase high performance liquid chro...

journal_title：Neurochemical research

authors： Uehara S,Uyemura K

更新日期：1985-08-01 00:00:00

abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...

journal_title：Neurochemical research

authors： Wang P,Liang X,Lu Y,Zhao X,Liang J

更新日期：2016-10-01 00:00:00

abstract：:In our previous study vesamicol, an inhibitor of the acetylcholine transporter of the cholinergic vesicles, inhibited veratridine-evoked external Ca(2+)-dependent acetylcholine release from striatal slices but did not influence acetylcholine release observed in Ca(2+)-free medium (4). Here we examined if the effect of...

journal_title：Neurochemical research

authors： Deri Z,Adam-Vizi V

更新日期：1992-06-01 00:00:00

abstract：:Ethylcholine mustard aziridinium ion (ECMA) was infused intracerebroventricularly (icv) to rats followed by measurement of two markers of presynaptic cholinergic neurons, choline acetyltransferase (ChAT) activity and high affinity choline transport (HAChT), in the hippocampus and cortex. Bilateral icv administration o...

journal_title：Neurochemical research

authors： Johnson GV,Simonato M,Jope RS

更新日期：1988-08-01 00:00:00

abstract：:The study aimed to directly measure in vivo superoxide radical (O*2) a direct indicator of oxidative stress, in the brain of rats with experimentally induced obstructive jaundice by employing a new quantitative ultrasensitive fluorescent assay requiring minimum sample. O*2 anion is specific for dihydroethidine (DHE) a...

journal_title：Neurochemical research

authors： Konstantinou D,Mavrakis A,Grintzalis K,Papapostolou I,Assimakopoulos SF,Chroni E,Georgiou C

更新日期：2008-06-01 00:00:00

abstract：:Using the replication-defective adenovirus vector, we overexpressed rat glia maturation factor (GMF) in primary astrocyte cultures derived from embryonic rat brains. Among the three isoforms of MAP kinase, there was a big increase in the phosphorylation of p38, as detected with Western blotting using the phosphospecif...

journal_title：Neurochemical research

authors： Zaheer A,Yorek MA,Lim R

更新日期：2001-12-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:In this study, we were interested to compare the responsiveness to growth factors, NGF, b-FGF and EGF and cytokines, IL1 beta, and TNF-alpha, in late passages (74-79) C6 glial cells committed astrocytes and astrocytes of advanced passages (26-28) in cultures derived from aged mouse cerebral hemispheres (MACH). Culture...

journal_title：Neurochemical research

authors： Kazazoglou T,Fleischer-Lambropoulos E,Geladopoulos T,Kentroti S,Stefanis C,Vernadakis A

更新日期：1996-05-01 00:00:00

abstract：:The tyrosine phosphatase inhibitor BpV(phen) stimulated a concentration-dependent increase of phospholipase C (PLC) activity in bovine adrenal medullary chromaffin cells. This response was accompanied by an increase in PLCgamma1 tyrosine phosphorylation and its cytosketetal translocation. Insulin, at high concentratio...

journal_title：Neurochemical research

authors： Roberts-Thomson EL,Herd LM,Saunders HI,Dunkley PR,Bunn SJ

更新日期：2004-10-01 00:00:00

abstract：:Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-old rats and lowest in adults, while the density of muscarinic binding...

journal_title：Neurochemical research

authors： Balduini W,Costa LG,Murphy SD

更新日期：1990-01-01 00:00:00

abstract：:Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to ...

journal_title：Neurochemical research

authors： Aguilar JS,Ballesta JJ,Reig JA,Palmero M,Viniegra S,Criado M

更新日期：1992-12-01 00:00:00

abstract：:In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawle...

journal_title：Neurochemical research

authors： Yildirim M,Aydin-Abidin S,Abidin I,Akca M,Canpolat S,Cansu A

更新日期：2013-08-01 00:00:00

abstract：:We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-family member thioredoxin (THX), and asked whether changes in PDI/THX were associated with production of oxidative/nitro...

journal_title：Neurochemical research

authors： Tshala-Katumbay D,Desjardins P,Sabri M,Butterworth R,Spencer P

更新日期：2009-11-01 00:00:00

abstract：:We have adopted the PC12 cell line as in vitro cell model for studying Dp71 function in neuronal cells. These cells express a cytoplasmic (Dp71f) and a nuclear (Dp71d) isoform of Dp71 as well as various dystrophin-associated proteins (DAPs). In this study, we revealed by confocal microscopy analysis and Western blotti...

journal_title：Neurochemical research

authors： Villarreal-Silva M,Suárez-Sánchez R,Rodríguez-Muñoz R,Mornet D,Cisneros B

更新日期：2010-03-01 00:00:00

abstract：:Synaptosomal membrane proteins solubilized with 8% CHAPS-8 M urea were analyzed with two-dimensional electrophoresis (2DE). The membrane proteins were resolved up to 250 spots on a 2DE map, ranging in isoelectric points (pI) from 3.5 to 10.0 and molecular weights (MW) from 10 kDa to 200 kDa. Comparison of the mapped p...

journal_title：Neurochemical research

authors： Ishioka N,Oda T,Natake Y,Kurioka S

更新日期：1990-05-01 00:00:00

abstract：:Glycogen is the main storage form of glucose in the brain. In contrast with previous beliefs, brain glycogen has recently been shown to play important roles in several brain functions. A fraction of metabolized glucose molecules are being shunted through glycogen before reentering the glycolytic pathway, a phenomenon ...

journal_title：Neurochemical research

authors： Jakobsen E,Bak LK,Walls AB,Reuschlein AK,Schousboe A,Waagepetersen HS

更新日期：2017-09-01 00:00:00

abstract：:MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...

journal_title：Neurochemical research

authors： Ji W,Jiao J,Cheng C,Shao J

更新日期：2018-10-01 00:00:00

abstract：:Exercise increases both the consumption of oxygen and the production of reactive species in biological tissues, and this is counterbalanced by antioxidant adaptations to regular physical training. When the intensity of exercise fluctuates between mild and moderate, it improves the status of reduction-oxidation balance...

journal_title：Neurochemical research

authors： Speck AE,Tromm CB,Pozzi BG,Paganini CS,Tuon T,Silveira PC,Aguiar AS Jr,Pinho RA

更新日期：2014-08-01 00:00:00

abstract：:Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity ca...

journal_title：Neurochemical research

authors： Liu H,Song Z,Liao D,Zhang T,Liu F,Zhuang K,Luo K,Yang L

更新日期：2015-01-01 00:00:00

abstract：:The effect of ageing and the relationships between the catalytic properties of enzymes linked to Krebs' cycle, electron transfer chain, glutamate and aminoacid metabolism of cerebral cortex, a functional area very sensitive to both age and ischemia, were studied on mitochondria of adult and aged rats, after complete i...

journal_title：Neurochemical research

authors： Villa RF,Gorini A,Hoyer S

更新日期：2009-12-01 00:00:00

abstract：:The standard ELISA technique was improved for the detection of antigalactocerebroside antibody in biological fluid. Mouse monoclonal antigalactocerebroside antibody was used to demonstrate specificity and sensitivity of the technique. After optimization of the assay, the usefulness of this measurement for the evaluati...

journal_title：Neurochemical research

authors： Ichioka T,Uobe K,Stoskopf M,Kishimoto Y,Tennekoon G,Tourtellotte WW

更新日期：1988-03-01 00:00:00

abstract：:Social isolation is one of the most potent stressors in the prepubertal period and may influence disease susceptibility or resilience in adulthood. The glucocorticoid response and, consequently, the adaptive response to stress involve important changes in mitochondrial functions and apoptotic signaling. Previous studi...

journal_title：Neurochemical research

authors： Krolow R,Noschang C,Arcego DM,Pettenuzzo LF,Weis SN,Marcolin ML,Huffell AP,Mota CS,Dalmaz C

更新日期：2013-02-01 00:00:00

abstract：:Aging is accompanied by the loss of memory and cognitive functions. The extracellular signal-regulated kinase (ERK) pathway has been shown to play an essential role in synaptic plasticity and memory. Although a reduction in basal ERK1/2 activity has been found in the cerebral cortex in aged rats, changes in ERK1/2 mRN...

journal_title：Neurochemical research

authors： Simonyi A,Murch K,Sun GY

更新日期：2003-09-01 00:00:00

abstract：:The effects of palmitate on intracellular and extracellular amino acid concentrations of cultured astrocytes was studied. Exposure of astrocytes to either 0.72 mM or 0.36 mM palmitate was associated with a significant reduction in the intracellular pool of glutamine and taurine. In contrast, the intracellular concentr...

journal_title：Neurochemical research

authors： Yudkoff M,Nissim I,Nissim I,Stern J,Pleasure D

更新日期：1989-04-01 00:00:00