Abstract:
:There is ample evidence stating Polychlorinated biphenyls (PCBs) as neurotoxins. In the current study, we have analyzed the behavioural impact of PCBs exposure in adult rats and assessed the simultaneous effect of antioxidant melatonin against the PCBs action. The rats were grouped into four and treated intraperitoneally with vehicle, PCBs, PCBs + melatonin and melatonin alone for 30 days, respectively. After the treatment period the rats were tested for locomotor activity and anxiety behaviour analysis. We confirmed the neuronal damage in the cerebral cortex by molecular and histological analysis. Our data indicates that there is impairment in locomotor activity and behaviour of PCBs treated rats compared to control. The simultaneous melatonin treated rat shows increased motor coordination and less anxiety like behaviour compared to PCBs treated rats. Molecular and histological analysis supports that, the impaired motor coordination in PCBs treated rats is due to neurodegeneration in motor cortex region. The results proved that melatonin treatment improved the motor co-ordination and reduced anxiety behaviour, prevented neurodegeneration in the cerebral cortex of PCBs-exposed adult male rats.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Bavithra S,Selvakumar K,Sundareswaran L,Arunakaran Jdoi
10.1007/s11064-016-2087-6subject
Has Abstractpub_date
2017-02-01 00:00:00pages
428-438issue
2eissn
0364-3190issn
1573-6903pii
10.1007/s11064-016-2087-6journal_volume
42pub_type
杂志文章abstract::The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and s...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-013-0991-6
更新日期:2013-05-01 00:00:00
abstract::Diisopropyl phosphorofluoridate (DFP) produces type I organophosphorus ester-induced delayed neurotoxicity in humans and sensitive animal species. This is accompanied by enhanced Ca2+/CaM-dependent protein kinase II (CaM-kinase II) activity, and [125I]calmodulin binding to CaM-kinase II in DFP-treated hen brain supern...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969081
更新日期:1993-03-01 00:00:00
abstract::Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals. It was found that adenosine...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1012392719601
更新日期:2001-09-01 00:00:00
abstract::The effect of oxidative stress, induced by Fe(2+)-EDTA system, on Na+,K(+)-ATPase, Na+/CA2+ exchanger and membrane fluidity of synaptosomes was investigated. Synaptosomes isolated from gerbil whole forebrain were incubated in the presence of 200 microM FeSO4-EDTA per mg of protein at 37 degrees C for 30 min. The oxida...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021918931780
更新日期:1997-12-01 00:00:00
abstract::The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022869222652
更新日期:2003-04-01 00:00:00
abstract::It is reported that CNS hemorrhage causes membrane dysfunction and may exacerbate this damage as a result of secondary ischemia or hypoxia. Since hyperbaric oxygenation improves oxygen metabolism, it may reduce this membrane damage. The present study was conducted to reveal whether hyperbaric oxygenation influences me...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966765
更新日期:1993-09-01 00:00:00
abstract::The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9187-7
更新日期:2007-02-01 00:00:00
abstract::Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive. The aim of the current study was to determine if targeting oxidative stress with the catalytic antioxidant, AEOL10150, would reduce p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2273-1
更新日期:2017-07-01 00:00:00
abstract::The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000013747.04964.46
更新日期:2004-02-01 00:00:00
abstract::Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020716304520
更新日期:1998-08-01 00:00:00
abstract::It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activity of neurons, but the detailed mechanism is still an open question. In this study, ES was used to stimulate c...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1197-7
更新日期:2014-01-01 00:00:00
abstract::Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965323
更新日期:1986-04-01 00:00:00
abstract::Several previous studies utilizing selective pharmacological antagonists have demonstrated that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for the treatment of numerous disorders of the central nervous system, but the role of mGluR5 activation in traumatic brain injury (TBI) is ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0691-z
更新日期:2012-05-01 00:00:00
abstract::In this communication, the effect of acute treatment with lamotrigine (LTG) was investigated on release of main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-induced and PTZ-kindled freely moving rats using micro dialysis. The results show that, ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0942-7
更新日期:2013-03-01 00:00:00
abstract::The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1262-x
更新日期:2014-04-01 00:00:00
abstract::Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we cha...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9434-6
更新日期:2008-01-01 00:00:00
abstract::We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9751-4
更新日期:2008-10-01 00:00:00
abstract::Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-008-9872-9
更新日期:2009-04-01 00:00:00
abstract::The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-009-9922-y
更新日期:2009-04-01 00:00:00
abstract::Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007632326953
更新日期:2000-11-01 00:00:00
abstract::Glutamine synthetase (GS) is the key enzyme in cerebral glutamine production. Understanding the regulation of the expression of GS is important for definition of the control of glutamine metabolism in brain. Therefore, we studied the control of GS expression by 8-bromo cyclic AMP in primary cultures of astrocytes prep...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973746
更新日期:1990-06-01 00:00:00
abstract::Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9567-7
更新日期:2008-11-01 00:00:00
abstract::Increasing evidence indicates that adhesion molecules are critically involved in the regulation of mechanisms of synaptic plasticity including synapse formation, but also synaptic remodeling associated to changes in synaptic strength. Among these, the Neural Cell Adhesion Molecule (NCAM) and its polysialylated form PS...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9653-5
更新日期:2008-03-20 00:00:00
abstract::The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973322
更新日期:1988-02-01 00:00:00
abstract::1-Methyl-4-phenylpyridinium (MPP(+)) or 6-hydroxydopamine (6-OHDA) caused a nuclear damage, the mitochondrial membrane permeability changes, leading to the cytochrome c release and caspase-3 activation, the formation of reactive oxygen species and the depletion of GSH in PC12 cells. Nicardipine (a calcium channel bloc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9088-9
更新日期:2006-07-01 00:00:00
abstract::Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation and chemotherapy, this cancer recurs within short time and median survival after diagnosis is less than a year. Glioblastoma stem cells (GSCs) left in the brain after surgery is thought to explain the inevitable recurre...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1868-2
更新日期:2016-07-01 00:00:00
abstract::Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022075508176
更新日期:1997-07-01 00:00:00
abstract::Acute tryptophan depletion (ATD) is extensively used to investigate the role of central serotonin (5-HT). However, several studies reported that ATD had no significant effect on central 5-HT concentration and some ATD-induced changes was independent of 5-HT in the rodent brain. Therefore, the potential mechanism of AT...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1177-y
更新日期:2013-12-01 00:00:00
abstract::The effects of vinpocetine on internal Na+ (Na(i)), cAMP accumulation, internal Ca2+ (Ca(i)) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 microM) or high K+ (30 mM) were used as depolarizing agents. R...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021164418478
更新日期:1999-12-01 00:00:00
abstract::Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968406
更新日期:1992-12-01 00:00:00