GABA metabolism in Venezuelan equine encephalomyelitis virus infection.

abstract：:Alpha adrenergic receptor subtypes in rat hippocampal membranes were studied, using [3H] clonidine as the radioactive ligand. On the basis of competitive binding studies, using the selective antagonist-prazosin, WB-4101, and yohimbine, [3H] clonidine appeared to bind to a population of presynaptic sites that are pharm...

journal_title：Neurochemical research

authors： George CR

更新日期：1982-02-01 00:00:00

abstract：:The effect of ageing and the relationships between the catalytic properties of enzymes linked to Krebs' cycle, electron transfer chain, glutamate and aminoacid metabolism of cerebral cortex, a functional area very sensitive to both age and ischemia, were studied on mitochondria of adult and aged rats, after complete i...

journal_title：Neurochemical research

authors： Villa RF,Gorini A,Hoyer S

更新日期：2009-12-01 00:00:00

abstract：:Antibodies to synthetic myelin basic protein peptide S82 (TTHYG-SLPQKAQGHRPQDEG) did not react with synthetic peptide S8 (GSLPQKAQGHRPQDENG) and only partially so with synthetic peptide S79 (AQGHRPQDEG); however, the antibodies did react to a considerable extent with an equimolar mixture of S8 and S79. Since the anti-...

journal_title：Neurochemical research

authors： Day ED,Hashim GA

更新日期：1984-10-01 00:00:00

abstract：:The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...

journal_title：Neurochemical research

authors： de Fiebre CM,Wu P,Notabartolo D,Millard WJ,Meyer EM

更新日期：1994-06-01 00:00:00

abstract：:Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...

journal_title：Neurochemical research

authors： Chavko M,Burda J,Marsala J

更新日期：1986-06-01 00:00:00

abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...

journal_title：Neurochemical research

authors： Gonçalves C,Dos Santos DB,Portilho SS,Lopes MW,Ghizoni H,de Souza V,Mack JM,Naime AA,Dafre AL,de Souza Brocardo P,Prediger RD,Farina M

更新日期：2018-03-01 00:00:00

abstract：:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...

journal_title：Neurochemical research

authors： Blagova OE,Budantsev AY,Sytinsky IA,Lajtha A

更新日期：1982-11-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:Human neuroblastoma cholinergic LA-N-2 cells were used as an experimental model to test the possibility that the methylation of phosphoethanolamine (PEtn) to phosphocholine (PCho) and free choline (Cho) (Andriamampandry et al. 1989) could contribute to acetylcholine (AcCho) synthesis. LA-N-2 cells were incubated with ...

journal_title：Neurochemical research

authors： Haidar NE,Carrara M,Andriamampandry C,Kanfer JN,Freysz L,Dreyfus H,Massarelli R

更新日期：1994-01-01 00:00:00

abstract：:Detergents Triton X-100, sodium deoxycholate, and octyl-beta-D-glucopyranoside, and proteinase papain proved to be excellent agents solubilizing the gamma-glutamyltransferase (gamma-GT) from human brain cortex microvessels. Ficin also solubilized gamma-GT but to a lesser extent than papain. The relative molecular mass...

journal_title：Neurochemical research

authors： Veselý J,Cernoch M

更新日期：1984-07-01 00:00:00

abstract：:VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors an...

journal_title：Neurochemical research

authors： Mizoguchi T,Shimazawa M,Ohuchi K,Kuse Y,Nakamura S,Hara H

更新日期：2019-02-01 00:00:00

abstract：:We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized ...

journal_title：Neurochemical research

authors： Marazziti D,Betti L,Giannaccini G,Rossi A,Masala I,Baroni S,Cassano GB,Lucacchini A

更新日期：2001-03-01 00:00:00

abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...

journal_title：Neurochemical research

authors： An L,Li G,Si J,Zhang C,Han X,Wang S,Jiang L,Xie K

更新日期：2016-05-01 00:00:00

abstract：:The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and G...

journal_title：Neurochemical research

authors： Battistin L,Varotto M,Berlese G,Roman G

更新日期：1984-02-01 00:00:00

abstract：:Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema ...

journal_title：Neurochemical research

authors： Nelson SR,Olson JP

更新日期：1987-06-01 00:00:00

abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...

journal_title：Neurochemical research

authors： Hartley DM,Snodgrass SR

更新日期：1990-07-01 00:00:00

abstract：:We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA)...

journal_title：Neurochemical research

authors： Hamaue N,Ogata A,Terado M,Ohno K,Kikuchi S,Sasaki H,Tashiro K,Hirafuji M,Minami M

更新日期：2006-12-01 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is a neurovisceral disorder characterized by lysosomal sequestration of endocytosed LDL-cholesterol, premature and abnormal enrichment of cholesterol in trans Golgi cisternae and accompanying anomalies in intracellular sterol trafficking. In addition to cholesterol, the NPC lesion has...

journal_title：Neurochemical research

authors： Vanier MT

更新日期：1999-04-01 00:00:00

abstract：:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...

journal_title：Neurochemical research

authors： Ghiani CA,Beltran-Parrazal L,Sforza DM,Malvar JS,Seksenyan A,Cole R,Smith DJ,Charles A,Ferchmin PA,de Vellis J

更新日期：2007-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease, with genetics and environment contributing to the disease onset. The limited pathological cognize of the disease restrained the approaches to improve the clinical treatment. Recently, studies showed that endoplasmic reticulum (ER) stress played an important role...

journal_title：Neurochemical research

authors： Ning B,Deng M,Zhang Q,Wang N,Fang Y

更新日期：2016-08-01 00:00:00

abstract：:The phosphoinositide signal transduction system, and particularly, phospholipase Cbeta isozymes, are relevant in the etiopathogeny of human neuropsychiatric pathologies such as depression. Stimulation of phospholipase Cbeta activity by muscarinic receptors and G proteins was determined in crude and synaptosomal membra...

journal_title：Neurochemical research

authors： Garro MA,López de Jesús M,Ruíz de Azúa I,Callado LF,Meana JJ,Sallés J

更新日期：2004-07-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:The copper-transporting ATPases Atp7A and Atp7B play a major role in controlling intracellular copper levels. In addition, they are believed to deliver copper to the copper-requiring proteins destined for the secretory vesicles. One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepin...

journal_title：Neurochemical research

authors： Gerbasi V,Lutsenko S,Lewis EJ

更新日期：2003-06-01 00:00:00

abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...

journal_title：Neurochemical research

authors： Herschman HR,Ferguson GD,Feldman JD,Farias-Eisner R,Vician L

更新日期：2000-05-01 00:00:00

abstract：:Experimentalists would like to perform large-scale expression analysis on samples drawn from small cell populations and even single cells. Amplification of the source material is required to assay such small samples under all existing array technologies. In this report we consider the very different theoretical proper...

journal_title：Neurochemical research

authors： Shaw CA

更新日期：2002-10-01 00:00:00

abstract：:Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...

journal_title：Neurochemical research

authors： Ma Y,Sun S,Zhang J,Chen Z,Guo F,Du Y,Zhang J

更新日期：2016-04-01 00:00:00

abstract：:The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...

journal_title：Neurochemical research

authors： Kar F,Hacioglu C,Uslu S,Kanbak G

更新日期：2019-08-01 00:00:00

abstract：:The number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the spinal dorsal horn evoked by noxious stimulation was previously shown to be increased following peripheral nerve injury, and this increase was proposed to reflect the neuropathic pain state. The aim of this study was to investigate whether anoma...

journal_title：Neurochemical research

authors： Terayama R,Kishimoto N,Yamamoto Y,Maruhama K,Tsuchiya H,Mizutani M,Iida S,Sugimoto T

更新日期：2015-03-01 00:00:00

abstract：:Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...

journal_title：Neurochemical research

authors： Seo JH,Chang JH,Song SH,Lee HN,Jeon GS,Kim DW,Chung CK,Cho SS

更新日期：2008-07-01 00:00:00

abstract：:In this study, we were interested to compare the responsiveness to growth factors, NGF, b-FGF and EGF and cytokines, IL1 beta, and TNF-alpha, in late passages (74-79) C6 glial cells committed astrocytes and astrocytes of advanced passages (26-28) in cultures derived from aged mouse cerebral hemispheres (MACH). Culture...

journal_title：Neurochemical research

authors： Kazazoglou T,Fleischer-Lambropoulos E,Geladopoulos T,Kentroti S,Stefanis C,Vernadakis A

更新日期：1996-05-01 00:00:00