Acetylcholinesterase inhibitor ENA-713 protects against ischemia-induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia.

abstract：:Hypoxia is one of the major common components of vascular risk factors for pathogenesis of Alzheimer's disease. This study investigated the possible relationship between hypoxia and alternative splicing of the excitatory amino acid transporter 2 (EAAT2) in a transgenic model for Alzheimer's disease. We used an APP23 m...

journal_title：Neurochemical research

authors： Münch C,Zhu BG,Mink A,Seefried U,Riepe MW,Ludolph AC,Meyer T

更新日期：2008-06-01 00:00:00

abstract：:Serotonin uptake and metabolism was studied in ependymal primary cultures. Serotonin uptake was facilitated by two different systems, one of which was the neuronal serotonin transporter SERT, exhibiting a Vmax value of 3.8+/-0.1 pmol x min(-1) x (mg protein)(-1) and an apparent Michaelis-Menten constant of 0.41+/-0.03...

journal_title：Neurochemical research

authors： Verleysdonk S,Hamprecht B,Rapp M,Wellard J

更新日期：2004-09-01 00:00:00

abstract：:We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (t...

journal_title：Neurochemical research

authors： Ishrat T,Pillai B,Ergul A,Hafez S,Fagan SC

更新日期：2013-12-01 00:00:00

abstract：:The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M1AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did no...

journal_title：Neurochemical research

authors： Pintor A,Fortuna S,Lorenzini P,Pascale A,Battaini F,Avellino C,Malvezzi Campeggi L,Salvati S

更新日期：1996-05-01 00:00:00

abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...

journal_title：Neurochemical research

authors： Colwell CS,Ghiani CA

更新日期：2020-03-01 00:00:00

abstract：:Excessive hyperbilirubinemia can cause irreversible neurological damage in the neonatal period. However, the complete understanding of the pathogenesis of unconjugated bilirubin (UCB) encephalopathy remains a matter of debate. This study investigates whether UCB inhibits the endocytosis of cationized ferritin (CF) by ...

journal_title：Neurochemical research

authors： Silva RF,Mata LM,Gulbenkian S,Brites D

更新日期：2001-07-01 00:00:00

abstract：:Thiamine deficiency (TD) produces severe neurodegenerative lesions. Studies have suggested that primary neurodegenerative events are associated with both oxidative stress and inflammation. Very little is known about the downstream effects on intracellular signaling pathways involved in neuronal death. The primary aim ...

journal_title：Neurochemical research

authors： Medeiros RCN,Moraes JO,Rodrigues SDC,Pereira LM,Aguiar HQDS,de Cordova CAS,Yim Júnior A,de Cordova FM

更新日期：2020-04-01 00:00:00

abstract：:Subacute exposure to manganese (Mn) produced Parkinson's disease-like syndrome called Manganism. Chronic onset and progression are characteristics of Manganism, therefore, this study aimed to examine Mn toxicity following chronic exposures. Male Sprague-Dawley rats were injected Mn2+ 1 and 5 mg/kg, every 10 days for 1...

journal_title：Neurochemical research

authors： Fan XM,Luo Y,Cao YM,Xiong TW,Song S,Liu J,Fan QY

更新日期：2020-08-01 00:00:00

abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...

journal_title：Neurochemical research

authors： Redzic ZB,Malatiali SA,Al-Bader M,Al-Sarraf H

更新日期：2010-09-01 00:00:00

abstract：:The current studies focus on what mechanisms regulate the concentration of PLP mRNA in cells. The PLP mRNA is very stable and these studies suggest that its stability is regulated by a trans-acting factor specific to oligodendrocytes. In order to test whether the 3'untranslated region (3'UTR) of the PLP mRNA might reg...

journal_title：Neurochemical research

authors： Mallon BS,Macklin WB

更新日期：2002-11-01 00:00:00

abstract：:We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...

journal_title：Neurochemical research

authors： Pilachowski J,Guilarte TR

更新日期：1993-12-01 00:00:00

abstract：:The first mentioning of the word "receptor" for the structure with which a bioactive compound should react for obtaining its specific influence on a physiological system goes back to the years around 1900. The receptor concept was adapted from the lock and key theory for the enzyme substrate and blockers interactions....

journal_title：Neurochemical research

authors： Kooistra AJ,de Graaf C,Timmerman H

更新日期：2014-10-01 00:00:00

abstract：:Evidence was accumulated indicating that cyclic nucleotides are involved in regulation of growth, differentiation and function of lymphoid cells. It was previously shown that the N-fragment (1-4) of thymosin beta 4 (Ac-Ser-Asp-Lys-Pro-OH) inhibits in vivo the entry of cell populations into S-phase. In the course of th...

journal_title：Neurochemical research

authors： Voelter W,Kapuzniotu A,Mihelic M,Gurvits B,Abrahamian G,Galoyan A

更新日期：1995-01-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...

journal_title：Neurochemical research

authors： Li S,Wang D,Tian Y,Wei H,Zhou Z,Liu L,Wang D,Dong JF,Jiang R,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...

journal_title：Neurochemical research

authors： Grove J,Kentroti S,Prasad K,Vernadakis A

更新日期：1997-03-01 00:00:00

abstract：:There is a growing body of evidence confirming the involvement of oxidative stress and inflammation in pathogenesis of schizophrenia. Inter-individual variation in antioxidant capacity caused by different genetic profile could potentially influence patient's susceptibility to oxidative damage. In this study we evaluat...

journal_title：Neurochemical research

authors： Bošković M,Vovk T,Saje M,Goričar K,Dolžan V,Kores Plesničar B,Grabnar I

更新日期：2013-02-01 00:00:00

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-b...

journal_title：Neurochemical research

authors： Nakanishi K,Tokita Y,Aono S,Ida M,Matsui F,Higashi Y,Oohira A

更新日期：2010-08-01 00:00:00

abstract：:Mice infected with the Venezuelan equine encephalomyelitis virus showed a significant decrease in the GABA content of cerebral hemispheres. Activity of the enzyme which synthetizes GABA, glutamate decarboxylase, is also reduced in whole cerebral hemispheres, neostriatum, and frontal cortex of infected animals, as comp...

journal_title：Neurochemical research

authors： Bonilla E,Ryder E,Ryder S

更新日期：1980-02-01 00:00:00

abstract：:It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...

journal_title：Neurochemical research

authors： Saito M,Smiley J,Toth R,Vadasz C

更新日期：2002-10-01 00:00:00

abstract：:Gangliosides, the acidic glycosphingolipids (GSLs) containing N-acetylgalactosamine and sialic acid are ubiquitous in the central nervous system. At least six DSL-glycosyltransferase activities (GLTs Gangliosides, the acidic glycosphingolipids (GSLs) containing N-acetylgalactosamine and sialic acid (or NAc-Neuraminic ...

journal_title：Neurochemical research

authors： Basu S,Ma R,Moskal JR,Basu M

更新日期：2012-06-01 00:00:00

abstract：:Proteolipid protein (PLP) is the major intrinsic membrane protein of CNS myelin and is expressed in oligodendrocytes as part of a coordinate program of myelin-specific gene activation. In order to identify the DNA sequences and proteins involved in the regulation of PLP transcription, we have analyzed the 5' flanking ...

journal_title：Neurochemical research

authors： Cambi F,Kamholz J

更新日期：1994-08-01 00:00:00

abstract：:One pathway by which tryptophan is metabolized in the brain as well as in the periphery is through cleavage of the indole ring to formylkynurenine and then kynurenine. Indoleamine-2,3-dioxygenase, the enzyme that catalyzes this cleavage, and kynurenine are distributed all across the different anatomic regions of brain...

journal_title：Neurochemical research

authors： Gál EM,Sherman AD

更新日期：1980-03-01 00:00:00

abstract：:The activity of gamma-glutamyltransferase localized in isolated brain synaptic membranes- and microvessels-enriched fractions was assayed after treatment of rats with either phenobarbital or ethanol. Phenobarbital increased the activity of gamma-glutamyltransferase in microvessels, without alteration of synaptic membr...

journal_title：Neurochemical research

authors： Ghersi-Egea JF,Minn A,Siest G

更新日期：1987-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...

journal_title：Neurochemical research

authors： Yang J,Dombrowski SM,Deshpande A,Krajcir N,El-Khoury S,Krishnan C,Luciano MG

更新日期：2011-11-01 00:00:00

abstract：:Human dental follicle cells (DFCs) are ectomesenchymal multipotent stem cells that form spheroid cell clusters (SCCs) under serum free medium cell culture conditions (SFM). Until today, molecular mechanisms for the formation of SCCs are unknown. In this study a quantitative phosphoproteomics approach revealed regulate...

journal_title：Neurochemical research

authors： Beck HC,Gosau M,Kristensen LP,Morsczeck C

更新日期：2014-07-01 00:00:00

abstract：:Senescence of the central nervous system is characterized by a progressive loss of neurons that can result in physiological and behavioral impairments. Reduction in the levels of central neurotrophic factors or of neurotrophin receptors may be one of the causes of the onset of these degenerative events. Thus, a proper...

journal_title：Neurochemical research

authors： Taglialatela G,Navarra D,Olivi A,Ramacci MT,Werrbach-Perez K,Perez-Polo JR,Angelucci L

更新日期：1995-01-01 00:00:00

abstract：:The present study has attempted to elucidate the alteration of serotonin turnover after 24 h REM sleep deprivation in different regions in brain of young rat. Sleep deprivation was induced by the inverted flower pot technique. Results of this study show increased serotonin turnover after 24 h REM sleep deprivation in ...

journal_title：Neurochemical research

authors： Senthilvelan M,Ravindran R,Samson J,Devi RS

更新日期：2006-01-01 00:00:00

abstract：:Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In this study, we examined the neuroprotective effect of TsI against ischemic damage and its neuroprotective mecha...

journal_title：Neurochemical research

authors： Park JH,Park Ok,Cho JH,Chen BH,Kim IH,Ahn JH,Lee JC,Yan BC,Yoo KY,Lee CH,Hwang IK,Kwon SH,Lee YL,Won MH,Choi JH

更新日期：2014-07-01 00:00:00

abstract：:Umbilical cord blood-derived marrow stromal cells (UCB-MSCs) with high proliferation capacity and immunomodulatory properties are considered to be a good candidate for cell-based therapies. But until now, little work has been focused on the differentiation of UCB-MSCs. In this work, UCB-MSCs were demonstrated to be ne...

journal_title：Neurochemical research

authors： Zeng Y,Rong M,Liu Y,Liu J,Lu M,Tao X,Li Z,Chen X,Yang K,Li C,Liu Z

更新日期：2013-12-01 00:00:00