Abstract:
:The coat protein of cardamom mosaic virus (CdMV), a member of the genus Macluravirus, assembles into virus-like particles when expressed in an Escherichia coli expression system. The N and C-termini of the coat protein were engineered with the Kennedy peptide and the 2F5 and 4E10 epitopes of gp41 of HIV. The chimeric proteins reacted with sera from HIV positive persons and also stimulated secretion of cytokines by peripheral blood mononuclear cells from these persons. Thus, a system based on the coat protein of CdMV can be used to display HIV-1 antigens.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Damodharan S,Gujar R,Pattabiraman S,Nesakumar M,Hanna LE,Vadakkuppattu RD,Usha Rdoi
10.1111/1348-0421.12045subject
Has Abstractpub_date
2013-05-01 00:00:00pages
374-85issue
5eissn
0385-5600issn
1348-0421journal_volume
57pub_type
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