abstract：:Chikungunya virus (CHIKV) an arthropod-borne Alphavirus is responsible for chikungunya fever and joint pain etc. Arthralgia is a major symptom; some patients recover early while others suffer for a very long time. Epidemiology and molecular characterization of three whole-genome sequences of CHIKV have been carried ou...

journal_title：Microbiology and immunology

authors： Khan N,Bhat R,Jain V,Raghuvendara B S,Patel AK,Ray P

更新日期：2020-12-21 00:00:00

abstract：:Influenza A virus (IAV) PA-X is a critical ribonuclease protein involved in host cell shutoff but its role in modulating the host immune response to IAV infection remains to be addressed. In this study, host cellular proteins that directly interact with PA-X were screened to investigate the biological function of PA-X...

journal_title：Microbiology and immunology

authors： Li M,Qi W,Chang Q,Chen R,Zhen D,Liao M,Wen J,Deng Y

更新日期：2020-11-26 00:00:00

abstract：:An important toxin-antitoxin (TA) system hok/sok, encoded by R1 plasmid of Escherichia coli, is involved in the post segregation killing of cells that have lost the plasmid. The lethal properties of hok protein have been utilized for the environmental containment of microbes and the development of potential vaccine ca...

journal_title：Microbiology and immunology

authors： Kaur A,Muthukumarappa T,Kanta P,Banday AZ,Chidananda MK

更新日期：2020-11-01 00:00:00

abstract：:Botulinum neurotoxin (BoNT) is the causative agent of botulism in humans and animals. Only BoNT serotype A subtype 1 (BoNT/A1) is used clinically because of its high potency and long duration of action. BoNT/A1 and BoNT/A subtype 2 (BoNT/A2) have a high degree of amino acid sequence similarity in the light chain (LC) ...

journal_title：Microbiology and immunology

authors： Kohda T,Tsukamoto K,Torii Y,Kozaki S,Mukamoto M

更新日期：2020-07-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the predominant pathogen for severe hand, foot, and mouth disease (HFMD) in children younger than 5 years, and currently no effective drugs are available for EV71. Thus, there is an urgent need to develop new drugs for the control of EV71 infection. In this study, LJ04 was extracted from Lamin...

journal_title：Microbiology and immunology

authors： Li Z,Cui B,Liu X,Wang L,Xian Q,Lu Z,Liu S,Cao Y,Zhao Y

更新日期：2020-03-01 00:00:00

abstract：:Burkholderia cepacia complex (Bcc) are opportunistic pathogens implicated with nosocomial infections, and high rates of morbidity and mortality, especially in individuals with cystic fibrosis (CF). B. cepacia are naturally resistant to different classes of antibiotics, and can subvert the host innate immune responses ...

journal_title：Microbiology and immunology

authors： Ganesh PS,Vishnupriya S,Vadivelu J,Mariappan V,Vellasamy KM,Shankar EM

更新日期：2020-02-01 00:00:00

abstract：:Specific tumor microenvironment signaling might prevent the maturation of dendritic cells (DCs) with tolerogenic and immunosuppressive potential accounting for antigen-specific unresponsiveness in the lymphoid organs and in the periphery. In the present study, dendritic cells treated with LLC lung cancer cell or 4T1 b...

journal_title：Microbiology and immunology

authors： Ma C,Su M,Shen K,Chen J,Ning Y,Qi C

更新日期：2020-01-01 00:00:00

abstract：:The pea cyv1 gene is a yet-to-be-identified recessive resistance gene that inhibits the infection of clover yellow vein virus (ClYVV). Previous studies confirmed that the cell-to-cell movement of ClYVV is inhibited in cyv1-carrying pea plants; however, the effect of cyv1 on viral replication remains unknown. In this s...

journal_title：Microbiology and immunology

authors： Taninaka Y,Nakahara KS,Hagiwara-Komoda Y

更新日期：2020-01-01 00:00:00

abstract：:The inflammasome is a multiprotein complex that mediates caspase-1 activation with subsequent maturation of the proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome is known to be activated by Staphylococcus aureus, one of the leading causes of bacteremia worldwide. Inflammasome activation and regulation ...

journal_title：Microbiology and immunology

authors： Rasmussen G,Idosa BA,Bäckman A,Monecke S,Strålin K,Särndahl E,Söderquist B

更新日期：2019-12-01 00:00:00

abstract：:Leptospira was isolated from environmental water in central Japan using selective medium comprising five antibiotics, namely sulfamethoxazole, trimethoprim, amphotericin B, fosfomycin, and 5-fluorouracil. Of 100 water samples 57 (57%) were culture-positive and 50 pure cultures were isolated. Of the 50 cultures isolate...

journal_title：Microbiology and immunology

authors： Masuzawa T,Uno R,Matsuhashi N,Yamaguchi M,Xu J,Nakamura S

更新日期：2019-11-01 00:00:00

abstract：:The potential role of wild boars as a source of erysipelas infection was investigated. An ELISA test of wild boar serum samples from 41 prefectures in Japan revealed that proportions of the Erysipelothrix rhusiopathiae-positive samples were very high in all the prefectures, and the mean positive rate was 95.6% (1312/1...

journal_title：Microbiology and immunology

authors： Shimoji Y,Osaki M,Ogawa Y,Shiraiwa K,Nishikawa S,Eguchi M,Yamamoto T,Tsutsui T

更新日期：2019-11-01 00:00:00

abstract：:Lancefield group C Streptococcus dysgalactiae causes infections in farmed fish. Here, the genome of S. dysgalactiae strain kdys0611, isolated from farmed amberjack (Seriola dumerili) was sequenced. The complete genome sequence of kdys0611 consists of a single chromosome and five plasmids. The chromosome is 2,142,780 b...

journal_title：Microbiology and immunology

authors： Nishiki I,Yoshida T,Fujiwara A

更新日期：2019-07-01 00:00:00

abstract：:Two gram-negative, catalase-negative, oxidase-positive strains (PAGU 1467T and PAGU 1468) isolated from patients with infective endocarditis were investigated to determine their taxonomic status. 16S rRNA gene sequence analysis indicated that the two strains were members of the Bergeyella-Chryseobacterium-Riemerella b...

journal_title：Microbiology and immunology

authors： Tomida J,Fujiwara N,Naka T,Morita Y,Sawabe E,Tojo N,Kikuchi K,Kawamura Y

更新日期：2019-03-01 00:00:00

abstract：:Streptococcus anginosus appears to be able to adhere to cultured epithelial cells or fibronectin and this may be associated with bacterial pathogenicity. In the present study, the molecular characteristics and virulence of the fibronectin-binding protein (FBP), Fbp62, of S. anginosus were investigated in animal models...

journal_title：Microbiology and immunology

authors： Kodama Y,Ishikawa T,Shimoyama Y,Sasaki D,Kimura S,Sasaki M

更新日期：2018-10-01 00:00:00

abstract：:Quantitative PCR (qPCR) of human T-cell leukemia virus type 1 (HTLV-1) provirus is used for HTLV-1 testing and for assessment of risk of HTLV-1-related diseases. In this study, a reference material was developed for standardizing HTLV-1 qPCR. Freeze-dried TL-Om1 cells diluted with Jurkat cells were prepared and an ass...

journal_title：Microbiology and immunology

authors： Kuramitsu M,Okuma K,Nakashima M,Sato T,Sasaki D,Hasegawa H,Umeki K,Kubota R,Sasada K,Sobata R,Matsumoto C,Kaneko N,Tezuka K,Matsuoka S,Utsunomiya A,Koh KR,Ogata M,Ishitsuka K,Taki M,Nosaka K,Uchimaru K,Iwanaga M

更新日期：2018-10-01 00:00:00

abstract：:H5N1 and H9N2 are the most important causes of avian influenza in China. Chemokines and cytokines play important roles in inflammatory response that clearly differ between H5N1 and H9N2 infection. To investigate whether chemokines and cytokines are differentially regulated following H5N1 and H9N2 AIVs infection, dynam...

journal_title：Microbiology and immunology

authors： Luo C,Liu J,Qi W,Ren X,Lu R,Liao M,Ning Z

更新日期：2018-05-01 00:00:00

abstract：:There was a significant amount of non-specific, but not of allergen (e.g., papain, mite feces and four kinds of pollen)-specific, IgE antibodies (Abs) in the sera of normal mice. An i.n. injection of each allergen without adjuvant into mice caused an increase in total IgE Ab titers with a similar time course in the se...

journal_title：Microbiology and immunology

authors： Hannya N,Ogita-Nakanishi H,Kato R,Ijiri Y,Hayashi T,Tanaka K,Kawata R,Takenaka H,Kubota T,Yoshida R

更新日期：2018-02-01 00:00:00

abstract：:Accurate and rapid detection of carbapenemases and identification of their types in Enterobacteriaceae are both still major challenges for clinical laboratories in attempting to prevent the intrusion and transmission of carbapenemase-producing Enterobacteriaceae. This study aimed to evaluate the performance of the MAS...

journal_title：Microbiology and immunology

authors： Ohsaki Y,Kubo R,Hobson J,Davies M,Osaka S,Hayashi W,Taniguchi Y,Koide S,Nagano Y,Nagano N

更新日期：2018-01-01 00:00:00

abstract：:Shigella sonnei, which has generally been associated with dysentery in developed countries, has recently been emerging in developing countries. Specifically, in Brazil few published studies have that molecularly characterized this species. The aims of this study were to analyze the efficacy of typing using multiple-lo...

journal_title：Microbiology and immunology

authors： Seribelli AA,Frazão MR,Medeiros MIC,Stehling EG,Falcão JP

更新日期：2017-12-01 00:00:00

abstract：:Trehalose 6,6'-dimycolate (TDM), or cord factor, is a crucial stimulus of immune responses during Mycobacterium tuberculosis infection. Although TDM has immuno-stimulatory properties, including adjuvant activity and the ability to induce granuloma formation, the mechanisms underlying these remain unknown. We hypothesi...

journal_title：Microbiology and immunology

authors： Lee WB,Yan JJ,Kang JS,Chung S,Kim LK

更新日期：2017-12-01 00:00:00

abstract：:Bordetella pertussis causes whooping cough, a severe and prolonged respiratory disease that results inhas high morbidity and mortality rates, particularly in developing countries. The number incidence of whooping cough cases is increasing in many countries despite high vaccine coverage. Causes for the re-emergence of ...

journal_title：Microbiology and immunology

authors： Suzuki K,Shinzawa N,Ishigaki K,Nakamura K,Abe H,Fukui-Miyazaki A,Ikuta K,Horiguchi Y

更新日期：2017-09-01 00:00:00

abstract：:Borna disease virus (BoDV), a prototype of mammalian bornavirus, is a non-segmented, negative strand RNA virus that often causes severe neurological disorders in infected animals, including horses and sheep. Unique among animal RNA viruses, BoDV transcribes and replicates non-cytopathically in the cell nucleus, leadin...

journal_title：Microbiology and immunology

authors： Fujino K,Yamamoto Y,Daito T,Makino A,Honda T,Tomonaga K

更新日期：2017-09-01 00:00:00

abstract：:This study investigated the mechanisms of resistance of 36 quinolone-resistant Salmonella Typhimurium strains isolated from outpatients with infectious diarrhea in Beijing Tian Tan Hospital between 2013 and 2015. The resistance spectrum of the 36 strains was measured using a broth dilution method. Class 1 integrons ha...

journal_title：Microbiology and immunology

authors： Yuan J,Guo W

更新日期：2017-04-01 00:00:00

abstract：:Mannose-capped lipoarabinomannan (ManLAM) is an immunomodulatory epitope of Mycobacterium tuberculosis (Mtb). An aptamer (ZXL1) that specifically binds to ManLAM from the virulent Mtb H37Rv strain was previously generated and it was found that ZXL1 functions as an antagonist, inhibiting the ManLAM-induced immunosuppre...

journal_title：Microbiology and immunology

authors： Pan Q,Yan J,Liu Q,Yuan C,Zhang XL

更新日期：2017-02-01 00:00:00

abstract：:Biofilm formation can cause refractory urinary tract infections (UTIs) in dogs; however, minimum biofilm eradication concentrations (MBECs) of veterinary drugs against canine uropathogens remain to be investigated. In this study, the MBECs of orbifloxacin (OBFX), trimethoprim-sulfamethoxazole (TMS) and amoxicillin/cla...

journal_title：Microbiology and immunology

authors： Shimizu T,Harada K

更新日期：2017-01-01 00:00:00

abstract：:Measles vaccines are highly effective and safe; however, the mechanism(s) underlying their attenuation has not been well understood. In this study, type I IFNs (IFN-α and IFN-β) induction in macaques infected with measles virus (MV) strains was examined. Type I IFNs were not induced in macaques infected with wild-type...

journal_title：Microbiology and immunology

authors： Van Nguyen N,Kato SI,Nagata K,Takeuchi K

更新日期：2016-07-01 00:00:00

abstract：:Mammals have co-evolved with retroviruses, including lentiviruses, over a long period. Evidence supporting this contention is that viral infectivity factor (Vif) encoded by lentiviruses antagonizes the anti-viral action of cellular apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) of the host...

journal_title：Microbiology and immunology

authors： Yoshikawa R,Izumi T,Nakano Y,Yamada E,Moriwaki M,Misawa N,Ren F,Kobayashi T,Koyanagi Y,Sato K

更新日期：2016-06-01 00:00:00

abstract：:Noroviruses cause acute gastroenteritis. Since multiple genotypes of norovirus co-circulate in humans, changing the genotype composition and eluding host immunity, development of a polyvalent vaccine against norovirus in which the genotypes of vaccine strains match the major strains in circulation in the target season...

journal_title：Microbiology and immunology

authors： Suzuki Y,Doan YH,Kimura H,Shinomiya H,Shirabe K,Katayama K

更新日期：2016-06-01 00:00:00

abstract：:Pneumocystis spp. are opportunistic fungal pathogens that are closely associated with severe pneumonia and pulmonary complications in patients with impaired immunity. In this study, the antigenic epitopes of the gene encoding the 55 kDa antigen fragment of Pneumocystis (p55), which may play an important role in Pneumo...

journal_title：Microbiology and immunology

authors： Fan H,Guo JY,Ma SL,Zhang N,An CL

更新日期：2016-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is a multifunctional protein that is involved in the HCV life cycle and pathogenesis. In this study, a host protein(s) interacting with NS5A by tandem affinity purification were searched for with the aim of elucidating the role of NS5A. An NS5A-interacting prote...

journal_title：Microbiology and immunology

authors： Chen M,Gan X,Yoshino K,Kitakawa M,Shoji I,Deng L,Hotta H

更新日期：2016-06-01 00:00:00

abstract：:Macrophages act as a reservoir for Mycobacterium tuberculosis, producing latent infection in approximately 90% of infected people. In this study, J774A.1 mouse macrophage cell line response and microRNA (miRNA) expression during infection with the most relevant mycobacterial strains for humans (M. tuberculosis, M. bov...

journal_title：Microbiology and immunology

authors： Elizabeth MC,Hernández de la Cruz ON,Mauricio CA

更新日期：2016-05-01 00:00:00

abstract：:JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system, in immunocompromised patients. Because no drugs have been approved for treating PML, many antiviral agents are currently being investigated for this purpose. The inhibitory effe...

journal_title：Microbiology and immunology

authors： Nukuzuma S,Nakamichi K,Kameoka M,Sugiura S,Nukuzuma C,Tasaki T,Takegami T

更新日期：2016-04-01 00:00:00

abstract：:Streptococcus suis infection induces formation of neutrophil extracellular traps (NETs) in vitro; however, the contribution of NETs-mediated killing to the pathogenesis of S. suis in vivo is yet to be elicited. The findings of the present study indicated that extracellular DNA fiber can be induced in a murine model in...

journal_title：Microbiology and immunology

authors： Zhao J,Lin L,Fu L,Han L,Zhang A

更新日期：2016-04-01 00:00:00

abstract：:Francisella tularensis, which causes tularemia, is widely distributed in the Northern hemisphere. F. tularensis strains isolated in Japan are genetically unique from non-Japanese strains; however, their phenotypic properties have not been well studied. Thus, mice were infected with representative Japanese strains of F...

journal_title：Microbiology and immunology

authors： Hotta A,Fujita O,Uda A,Yamamoto Y,Sharma N,Tanabayashi K,Yamada A,Morikawa S

更新日期：2016-03-01 00:00:00

abstract：:This study aimed to investigate the antifungal activity of Rubus chingii extract in combination with fluconazole (FLC) against FLC-resistant Candida albicans 100 in vitro. A R. chingii extract and FLC-resistant C. albicans fungus suspension were prepared. The minimum inhibitory concentration and fractional inhibitory ...

journal_title：Microbiology and immunology

authors： Han B,Chen J,Yu YQ,Cao YB,Jiang YY

更新日期：2016-02-01 00:00:00

abstract：:Natural killer cells, a critical component of the innate immune system, eradicate both virus-infected cells and tumor cells through cytotoxicity and secretion of cytokines. Human NK cell research has largely been based on in vitro studies because of the lack of appropriate animal models. In this study, a selective pro...

journal_title：Microbiology and immunology

authors： Hattori S,Matsuda K,Kariya R,Harada H,Okada S

更新日期：2016-02-01 00:00:00

abstract：:Of the various virulence mechanisms of the opportunistic pathogen Pseudomonas aeruginosa, the type III secretion system (TTSS) has been characterized as a major factor associated with acute lung injury, bacteremia and mortality. In addition, PcrV, a component protein of the TTSS, has been characterized as a protective...

journal_title：Microbiology and immunology

authors： Yasumoto H,Katoh H,Kinoshita M,Shimizu M,Hamaoka S,Akiyama K,Naito Y,Sawa T

更新日期：2016-02-01 00:00:00

abstract：:CD4(+) T cells play critical roles in protection against the blood stage of malarial infection; however, their uncontrolled activation can be harmful to the host. In this study, in which rodent models of Plasmodium parasites were used, the expression of inhibitory receptors on activated CD4(+) T cells and their cytoki...

journal_title：Microbiology and immunology

authors： Doe HT,Kimura D,Miyakoda M,Kimura K,Akbari M,Yui K

更新日期：2016-02-01 00:00:00

abstract：:Streptococcus pyogenes, a group A Streptococcus (GAS), has been recognized as the causative pathogen in patients with severe invasive streptococcal infection with or without necrotizing fasciitis. In recent epidemiological studies, Streptococcus dysgalactiae subsp. equisimilis (SDSE) has been isolated from severe inva...

journal_title：Microbiology and immunology

authors： Watanabe S,Takemoto N,Ogura K,Miyoshi-Akiyama T

更新日期：2016-01-01 00:00:00

abstract：:Although the BCG vaccine can prevent tuberculosis (TB) in infants, its ability to prevent adult pulmonary TB is reportedly limited. Therefore, development of a novel effective vaccine against pulmonary TB has become an international research priority. We have previously reported that intranasal vaccination of mice wit...

journal_title：Microbiology and immunology

authors： Fukui M,Shinjo K,Umemura M,Shigeno S,Harakuni T,Arakawa T,Matsuzaki G

更新日期：2015-12-01 00:00:00