Class-specific antibody response in acyclovir-treated and adenine arabinoside-treated patients with primary genital herpes simplex virus infection.

Abstract:

:Herpes simplex virus (HSV) class-specific antibody responses after primary genital herpes infection were evaluated with an enzyme-linked immunosorbent assay (ELISA) in 16 patients treated with acyclovir (ACV), given orally, and 17 patients treated with adenine arabinoside (Ara-A), given topically. ACV significantly suppressed the levels of IgM, IgA, and IgG. In the ACV-treated patients, IgM and IgG were not detected in 4 of the 16 and in 1 of the 16 patients, respectively. We must take into account this suppressive effect of ACV on antibody responses, especially on the IgM response, when serodiagnosis of HSV infection is made.

journal_name

Microbiol Immunol

authors

Kawana T,Hashido M,Koizumi Y

doi

10.1111/j.1348-0421.1995.tb03272.x

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

795-9

issue

10

eissn

0385-5600

issn

1348-0421

journal_volume

39

pub_type

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