Class-specific antibody response in acyclovir-treated and adenine arabinoside-treated patients with primary genital herpes simplex virus infection.


:Herpes simplex virus (HSV) class-specific antibody responses after primary genital herpes infection were evaluated with an enzyme-linked immunosorbent assay (ELISA) in 16 patients treated with acyclovir (ACV), given orally, and 17 patients treated with adenine arabinoside (Ara-A), given topically. ACV significantly suppressed the levels of IgM, IgA, and IgG. In the ACV-treated patients, IgM and IgG were not detected in 4 of the 16 and in 1 of the 16 patients, respectively. We must take into account this suppressive effect of ACV on antibody responses, especially on the IgM response, when serodiagnosis of HSV infection is made.


Microbiol Immunol


Kawana T,Hashido M,Koizumi Y




Has Abstract


1995-01-01 00:00:00












  • Germination-initiation and inhibitory activities of L- and D-alanine analogues for Bacillus subtilis spores. Modification of methyl group of L- and D-alanine.

    abstract::The ability of 33 compounds of L-alanine analogues over a wide range of concentrations to initiate germination of Bacillus subtilis spores was determined, and the inhibitory activity against L-alanine-initiated germination was determined for the above compounds and 22 of their D- and DL-isomers. Nineteen L-isomers wer...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Yasuda Y,Tochikubo K

    更新日期:1985-01-01 00:00:00

  • MASTDISCS combi Carba plus, a simple method for discriminating carbapenemase-producing Enterobacteriaceae, including OXA-48-type producers.

    abstract::Accurate and rapid detection of carbapenemases and identification of their types in Enterobacteriaceae are both still major challenges for clinical laboratories in attempting to prevent the intrusion and transmission of carbapenemase-producing Enterobacteriaceae. This study aimed to evaluate the performance of the MAS...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Ohsaki Y,Kubo R,Hobson J,Davies M,Osaka S,Hayashi W,Taniguchi Y,Koide S,Nagano Y,Nagano N

    更新日期:2018-01-01 00:00:00

  • Cross wall synthesis and the arrangement of the wall polymers in the cell wall of Staphylococcus spp.

    abstract::The growing process and the fine structure of the cross wall of Staphylococcus were investigated by electron microscopy. Examination of the tangentially sectioned cross wall revealed that it was initially synthesized as a thin cell wall layer by an invaginated cytoplasmic membrane. The wall thickness soon increased by...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Amako K,Umeda A

    更新日期:1984-01-01 00:00:00

  • Activation of Toll‐like receptor 9 inhibits lipopolysaccharide‐induced receptor activator of nuclear factor kappa‐ B ligand expression in rat B lymphocytes.

    abstract::B lymphocytes express multiple TLRs that regulate their cytokine production.We investigated the effect of TLR4 and TLR9 activation on receptor activator of NF‐kB ligand (RANKL) expression by rat spleen B cells. Splenocytes or purified spleen B cells from Rowett rats were cultured with TLR4 ligand Escherichia coli LPS ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Yu X,Lin J,Yu Q,Kawai T,Taubman MA,Han X

    更新日期:2014-01-01 00:00:00

  • Growth of starved Escherichia coli O157 cells in selective and non-selective media.

    abstract::Escherichia coli O157 strains starved in sterile deionized water (SDW) and filter-sterilized natural river water (SRW) were investigated with specific reference to their culturability in selective and non-selective media. Growth of the strains starved in both SDW and SRW were markedly suppressed with time in selective...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Sata S,Osawa R,Asai Y,Yamai S

    更新日期:1999-01-01 00:00:00

  • Pathogenicity of glycoprotein C-deficient herpes simplex virus 1 strain TN-1 which encodes truncated glycoprotein C.

    abstract::A clinical isolate of herpes simplex virus 1 (TN-1) from a stromal keratitis patient was found to be defective in the glycoprotein C (gC) gene (UL44), thus resulting in the production of truncated gC upon infection. To study the pathogenetic role of truncated gC, we prepared a recombinant LTN-8 derived from TN-1 with ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Minagawa H,Liu Y,Yoshida T,Hidaka Y,Toh Y,Mori R

    更新日期:1997-01-01 00:00:00

  • Functions and development of red pulp macrophages.

    abstract::Macrophages are extremely heterogeneous mononuclear phagocytes widely distributed throughout the body. They play unique roles in each organ where they reside. Among macrophage subsets, red pulp macrophages (RPMs) that localize in the splenic red pulp, are critical for maintenance of blood homeostasis by actively phago...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章,评审


    authors: Kurotaki D,Uede T,Tamura T

    更新日期:2015-02-01 00:00:00

  • Moraxella catarrhalis does not grow on nutrient agar without sodium chloride supplementation.

    abstract::None of the 58 Moraxella catarrhalis strains grew on nutrient agar without sodium chloride supplementation, whereas 49 of 51 commensal Neisseria spp. strains tested did. Growth on nutrient agar without sodium chloride supplementation could be used for screening between M. catarrhalis and commensal Neisseria spp. ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Chida T,Sawabe E,Ono E,Nishiyama H,Ebina K,Sato K,Watanabe Y,Kuroki T,Okamura N

    更新日期:2005-01-01 00:00:00

  • Differentiation between genera Rhodococcus and Nocardia by susceptibility testing to kanamycin and some other antituberculosis agents.

    abstract::The test for susceptibility to kanamycin is useful for differentiating between the genera Rhodococcus and Nocardia. All rhodococci except R. equi, R. erythropolis, and R. aurantiacus are susceptible to kanamycin, whereas all nocardiae except N. otitidis-caviarum are resistant to kanamycin. Tests for susceptibility to ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Tsukamura M

    更新日期:1988-01-01 00:00:00

  • Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress.

    abstract::Farnesol is well known as a quorum-sensing molecule of Candida albicans. To assess the pathological function of farnesol, its effects on macrophage viability and functions including growth inhibitory activities against C. albicans were examined in vitro. Murine macrophages, when cultured in the presence of 56-112 micr...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Abe S,Tsunashima R,Iijima R,Yamada T,Maruyama N,Hisajima T,Abe Y,Oshima H,Yamazaki M

    更新日期:2009-06-01 00:00:00

  • Herpes simplex virus US3 protein kinase regulates host responses and determines neurovirulence.

    abstract::The US3 of HSV encodes a serine/threonine protein kinase that is highly conserved among members of the alphaherpesviruses. It is an accessory gene that is not required for viral replication in cultured cells but appears essential for viral survival in humans. Although accumulating in vitro evidence suggested that the ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章,评审


    authors: Mori I

    更新日期:2012-06-01 00:00:00

  • Distribution of Clostridium botulinum in Japan and in Shinkiang district of China.

    abstract::Soil specimens obtained from several areas of Japan, which are closely located to or facing the Continental land of China, were examined for the distribution of Clostridium botulinum, especially pertaining to types A and B. A total of 266 specimens of Japan, when cultured, showed no type A or B toxicity, although 30 (...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Yamakawa K,Kamiya S,Nishida S,Yoshimura K,Yu H,Lu DY,Nakamura S

    更新日期:1988-01-01 00:00:00

  • The reduction of Fusobacterium nucleatum in mice is irrelevant to the nitric oxide induced by iNOS.

    abstract::Previously we reported that mice infected recurrently with live Fusobacterim nucleatum (Fn) synthesize a significant amount of NO between 12 hr and 24 hr after the Fn injection. We now investigated whether the NO has the capability of killing Fn, a gram-negative rod periodontal pathogen. The mice were divided into thr...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Kato C,Mikami M,Suzuki A,Saito K

    更新日期:2003-01-01 00:00:00

  • Comparison of Leptospira species isolated from environmental water and soil in Japan.

    abstract::Leptospira was isolated from environmental water in central Japan using selective medium comprising five antibiotics, namely sulfamethoxazole, trimethoprim, amphotericin B, fosfomycin, and 5-fluorouracil. Of 100 water samples 57 (57%) were culture-positive and 50 pure cultures were isolated. Of the 50 cultures isolate...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Masuzawa T,Uno R,Matsuhashi N,Yamaguchi M,Xu J,Nakamura S

    更新日期:2019-11-01 00:00:00

  • The fibronectin-binding protein homologue Fbp62 of Streptococcus anginosus is a potent virulence factor.

    abstract::Streptococcus anginosus appears to be able to adhere to cultured epithelial cells or fibronectin and this may be associated with bacterial pathogenicity. In the present study, the molecular characteristics and virulence of the fibronectin-binding protein (FBP), Fbp62, of S. anginosus were investigated in animal models...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Kodama Y,Ishikawa T,Shimoyama Y,Sasaki D,Kimura S,Sasaki M

    更新日期:2018-10-01 00:00:00

  • Experimental candida-induced arteritis in mice. Relation to arteritis in the mucocutaneous lymph node syndrome.

    abstract::An extract of Candida albicans isolated from a patient with typical mucocutaneous lymph node syndrome (MCLS) can produce coronary arteritis in a mouse when injected intraperitoneally. An unusual feature of this arteritis is that it is granulomatous, shows no fibrinoid change and is confined to the coronary arteries. T...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Murata H

    更新日期:1979-01-01 00:00:00

  • High molecular weight factor in FCS inhibits Helicobacter pylori VacA-binding to its receptor, RPTPbeta, on AZ-521.

    abstract::VacA, a secretory product of Helicobacter pylori, binds to its cell surface receptor, receptor tyrosine phosphatase (RPTP) beta, leading to cytoplasmic vacuolization of gastric epithelial AZ-521 cells. VacA binding to the cell surface and VacA-dependent vacuolization were inhibited by cell culture media containing fet...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Kimura T,Wada A,Nakayama M,Ogushi K,Nishi Y,De Guzman BB,Moss J,Hirayama T

    更新日期:2003-01-01 00:00:00

  • RpoS and oxidative stress conditions regulate succinyl-CoA: 3-ketoacid-coenzyme A transferase (SCOT) expression in Burkholderia pseudomallei.

    abstract::Burkholderia pseudomallei, a pathogenic gram-negative bacterium, causes the severe human disease melioidosis. This organism can survive in eukaryotic host cells by escaping reactive oxygen species via the regulation of stress responsive sigma factors, including RpoS. In B. pseudomallei, RpoS has been reported to play ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Chutoam P,Charoensawan V,Wongtrakoongate P,Kum-Arth A,Buphamalai P,Tungpradabkul S

    更新日期:2013-09-01 00:00:00

  • Characterization of a toxin-deficient Clostridium perfringens strain, KZ1340.

    abstract::Clostridium perfringens KZ1340, previously classified as Clostridium plagarum, is an isolate from Antarctic soil, and was identified as an alpha-, theta-, and kappa-toxin non-producing variant. On Southern hybridization, the variant was found to be defective in the pfoA (theta-toxin) gene, but the plc (alpha-toxin) an...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Shimizu T,Ohtani K,Ba-Thein W,Inui S,Nakamura S,Hayashi H

    更新日期:1996-01-01 00:00:00

  • Purification and characterization of Vibrio vulnificus protease.

    abstract::A protease was purified from a strain of Vibrio vulnificus isolated from the blood of a septicemic human. The vibrio was cultured in bacto peptone-yeast extract medium, and the protease was purified by a purification procedure including ultrafiltration of the culture supernatant with an Amicon YM 5 membrane, diethylam...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Miyoshi N,Shimizu C,Miyoshi S,Shinoda S

    更新日期:1987-01-01 00:00:00

  • Effect of the two-year milk-feeding on the gastrointestinal microflora of the cynomolgus monkey (Macaca fascicularis).

    abstract::The effect of the two-year milk-feeding on the gastrointestinal (GI) microflora of a cynomolgus monkey was determined. Bifidobacterium spp. in the animal fed with cow's milk alone were distributed in higher number in the stomach, duodenum, cecum, and rectum. The increasingly higher numbers of Lactobacillus spp. and Ca...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Benno Y,Honjo S,Mitsuoka T

    更新日期:1987-01-01 00:00:00

  • Early-shared Mycobacterium bovis bacillus Calmette-Guérin sub-strains induce Th1 cytokine production in vivo.

    abstract::Interleukin-12 is one of the cytokines that induce acquired immunity by progressing the differentiation of T cells. When antigens are presented by APCs, including macrophages and DCs, T cells are activated and produce the Th1 cytokines IL-2 and IFN-γ. We have previously reported greater IL-12 production from macrophag...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Taniguchi K,Miyatake Y,Hayashi D,Takami A,Itoh S,Yamamoto S,Hida S,Onozaki K,Takii T

    更新日期:2015-11-01 00:00:00

  • Sporadic carriers of human T-lymphotropic virus type I in northern Egypt.

    abstract::Sera from 3,158 individuals living in northern Egypt were tested for the presence of antibodies against human T-lymphotropic virus type I (HTLV-I) by the newly developed particle agglutination (PA) test. Ten sera gave a positive reaction in the PA test. Eight of these sera were examined further by Western blotting and...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: el-Farrash MA,Badr MF,Hawas SA,el-Nashar NM,Imai J,Komoda H,Hinuma Y

    更新日期:1988-01-01 00:00:00

  • Establishment of an assay system for the detection of translated materials of T-cell-replacing factor mRNA in Xenopus oocytes.

    abstract::We established an assay system for detecting T cell-replacing factor (TRF) activity of translated materials in Xenopus oocytes of poly (A)-positive mRNA extracted from a T cell hybrid cell line, B151K12 (B151) which constitutively produces TRF. Since it was difficult to detect TRF activity of the translated products o...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Tominaga A,Matsumoto M,Takahashi T,Harada N,Takatsu K

    更新日期:1986-01-01 00:00:00

  • Susceptibility of influenza viruses to interferon and to poly(I) . Poly(C) determined by the plaque reduction method.

    abstract::Susceptibility of eight strains of influenza A and B viruses to interferon and to poly(I) . poly(C) were determined by the plaque reduction method. All strains tested were slightly less susceptible than vesicular stomatitis virus (VSV) in an established line of canine kidney (MDCK) cells. The 50% plaque depression dos...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Machida H,Kuninaka A,Yoshino H

    更新日期:1980-01-01 00:00:00

  • Biological activities of lipopolysaccharide-like substance (LLS) extracted from Leptospira interrogans serovar canicola strain Moulton.

    abstract::The biological activities of lipopolysaccharide-like substance (LLS) extracted from Leptospira interrogans serovar canicola strain Moulton by the hot phenol-water method were studied in mice. The addition of 12.5 micrograms/ml or more of LLS fraction increased the incorporation of [3H]thymidine into in vitro cultured ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Shimizu T,Matsusaka E,Takayanagi K,Masuzawa T,Iwamoto Y,Morita T,Mifuchi I,Yanagihara Y

    更新日期:1987-01-01 00:00:00

  • Cloning and sequencing of the central region of the flagellin gene from the Gram-positive bacterium Clostridium tyrobutyricum ATCC 25755.

    abstract::The purpose of this study was to sequence the central part of the coding region of the Clostridium tyrobutyricum fiagellin gene to improve the immunoenzymatic counting of cells after milk filtration. The coding region was amplified by PCR, and the amplified products were cloned. A DNA sequence analysis of positive clo...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Arnold F,Bédouet L,Batina P,Robreau G

    更新日期:1999-01-01 00:00:00

  • Molecular ratio between borna disease viral-p40 and -p24 proteins in infected cells determined by quantitative antigen capture ELISA.

    abstract::We developed the antigen capture enzyme-linked immunosorbent assay (ELISA) systems for quantification of Borna disease virus (BDV) major antigens, p40 and p24. Using these ELISAs, we quantified the two proteins in various BDV-infected materials, including the cell lysates and culture supernatants as well as the homoge...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Watanabe M,Zhong Q,Kobayashi T,Kamitani W,Tomonaga K,Ikuta K

    更新日期:2000-01-01 00:00:00

  • Study of human metapneumovirus-associated lower respiratory tract infections in Egyptian adults.

    abstract::There is a deficiency in the data concerning the role of hMPV in lower respiratory tract infections in adults, and until now there has been no data available regarding the prevalence of hMPV in adults in our region. In the present study the association of hMPV with varieties of lower respiratory tract disorders in imm...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: El Sayed Zaki M,Raafat D,El-Metaal AA,Ismail M

    更新日期:2009-11-01 00:00:00

  • New epitope peptides derived from hepatitis C virus (HCV) 2a which have the capacity to induce cytotoxic T lymphocytes in HLA-A2+ HCV-infected patients.

    abstract::Because cytotoxic T lymphocytes (CTLs) play an important role in the specific immunotherapy of hepatitis C virus (HCV) infection, a series of CTL epitopes has been defined from HCV genotype 1a or 1b protein. Here, we attempted to identify HCV2a-derived epitopes that are capable of inducing HLA-A2-restricted and peptid...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章


    authors: Wang Y,Takao Y,Harada M,Yutani S,Ide T,Sata M,Itoh K,Yamada A

    更新日期:2006-01-01 00:00:00