Abstract:
:We have previously reported a mouse model of severe group A streptococcal infection (Microbiol. Immunol. 45: 777-786, 2001). When we injected Streptococcus pyogenes strains intramuscularly, the mice suffered from acute phase of infection for a few days but recovered from the illness and gained body weight. These mice, however, began to die after 3 weeks of infection, which we called 'delayed death.' Bacterial strains isolated from organs of the dead mice showed thick capsules. We, therefore, constructed a hyaluronic acid capsule gene, hasA, knockout mutant by homologous recombination and the effect of capsule on the death was observed. hasA knockout strain did not cause delayed death, though it caused acute death at high doses of infection. According to this result, the capsule is a critical pathogenic factor for causing the delayed death in our mouse model.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Iida K,Seki M,Saito M,Kawamura Y,Kajiwara H,Yoshida Sdoi
10.1111/j.1348-0421.2006.tb03777.xkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
127-30issue
2eissn
0385-5600issn
1348-0421pii
JST.JSTAGE/mandi/50.127journal_volume
50pub_type
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