Abstract:
:Germfree (GF) F344 rats developed severe adjuvant-induced arthritis with a 100% incidence after a single intradermal injection of heat-killed Mycobacterium bovis (BCG). Specific pathogene-free (SPF) rats developed less severe arthritis with a lower incidence. The rats colonized with Escherichia coli or Bacteroides developed mild disease comparable to that in SPF rats. The rats colonized with Bifidobacterium, Propionibacterium acnes, Lactobacillus casei, L. fermentum, L. murini, and L. acidophilus developed more severe disease than that in GF rats. Furthermore, the rats colonized with a mixture of E. coli and the above lactobacilli developed very mild disease similar to that in SPF rats. These results suggest that gram-negative bacteria, such as E. coli and Bacteroides, may suppress the disease, possibly through their lipopolysaccharides, and may be responsible for the lower susceptibility of SPF rats; gram-positive bacteria, such as Bifidobacterium, P. acnes, and lactobacilli, may enhance the disease, possibly through their peptidoglycans; and E. coli may play a dominant role in modulating the development of adjuvant-induced arthritis.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Kohashi O,Kohashi Y,Takahashi T,Ozawa A,Shigematsu Ndoi
10.1111/j.1348-0421.1985.tb00851.xsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
487-97issue
6eissn
0385-5600issn
1348-0421journal_volume
29pub_type
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journal_title:Microbiology and immunology
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journal_title:Microbiology and immunology
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journal_title:Microbiology and immunology
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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更新日期:1988-01-01 00:00:00
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journal_title:Microbiology and immunology
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更新日期:1983-01-01 00:00:00
abstract::Serum samples were collected from 938 pigs of 24 farms in Hokkaido, Kagoshima, and Okinawa prefectures in Japan in 2001-2005. Enzyme-linked immunosorbent assay (ELISA) was used for the detection of antibodies to LipL32 antigen which is common to Leptospira interrogans. Samples positive in ELISA were then investigated ...
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journal_title:Microbiology and immunology
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journal_title:Microbiology and immunology
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更新日期:1977-10-20 00:00:00
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journal_title:Microbiology and immunology
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00