Association between antibody response against cytomegalovirus strain-specific glycoprotein H epitopes and HLA-DR.

Abstract:

:The gH of CMV is a major target for strain-specific neutralizing antibodies. To verify whether there is a correlation between HLA-DR type and strain-specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA-DR10 and DR11 had antibodies to CMV gH than did those without HLA-DR10 and DR11. HLA-DR10 and DR11 may be associated with fewer/non-responders for strain-specific neutralizing antibodies.

journal_name

Microbiol Immunol

authors

Ishibashi K,Tokumoto T,Shirakawa H,Hashimoto K,Kushida N,Yanagida T,Shishido K,Aikawa K,Yamaguchi O,Toma H,Tanabe K,Suzutani T

doi

10.1111/j.1348-0421.2009.00134.x

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

412-6

issue

7

eissn

0385-5600

issn

1348-0421

pii

MIM134

journal_volume

53

pub_type

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