Abstract:
:The gH of CMV is a major target for strain-specific neutralizing antibodies. To verify whether there is a correlation between HLA-DR type and strain-specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA-DR10 and DR11 had antibodies to CMV gH than did those without HLA-DR10 and DR11. HLA-DR10 and DR11 may be associated with fewer/non-responders for strain-specific neutralizing antibodies.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Ishibashi K,Tokumoto T,Shirakawa H,Hashimoto K,Kushida N,Yanagida T,Shishido K,Aikawa K,Yamaguchi O,Toma H,Tanabe K,Suzutani Tdoi
10.1111/j.1348-0421.2009.00134.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
412-6issue
7eissn
0385-5600issn
1348-0421pii
MIM134journal_volume
53pub_type
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