Agr function is upregulated by photodynamic therapy for Staphylococcus aureus and is related to resistance to photodynamic therapy.

Abstract:

:Photodynamic therapy (PDT) has been considered a feasible alternative for antimicrobial therapy of multidrug-resistant pathogens. However, bacterial response mechanisms against PDT-generated photo-oxidative stress remain largely unknown. Herein, it is shown that the accessory gene regulator Agr is involved in Staphylococcus aureus response to photo-oxidative stress generated by laser-induced PDT with the photosensitizer chlorin e6 . Transcriptional profiling revealed that sublethal PDT induces a general stress response and also activates Agr-dependent gene regulation. Moreover, mutant S. aureus lacking Agr function showed hypersusceptibility to two independent PDT conditions with higher energy densities, demonstrating Agr-dependent S. aureus resistance against PDT.

journal_name

Microbiol Immunol

authors

Park HJ,Moon YH,Yoon HE,Park YM,Yoon JH,Bang IS

doi

10.1111/1348-0421.12070

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

547-52

issue

8

eissn

0385-5600

issn

1348-0421

journal_volume

57

pub_type

杂志文章
  • Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness.

    abstract::Us3 is a serine-threonine protein kinase that is encoded by herpes simplex virus 1 (HSV-1). In experimental animal models of HSV infection, peripheral and intracranial inoculations can be used to study viral pathogenicity in peripheral sites (e.g., eyes and vagina) and central nervous systems (CNSs), respectively. In ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12108

    authors: Koyanagi N,Imai T,Arii J,Kato A,Kawaguchi Y

    更新日期:2014-01-01 00:00:00

  • Electron microscopic study of hemadsorption on vaccinia virus infected cells.

    abstract::Hemadsorption (HAD) induced in HEp-2 cells infected with vaccinia virus was observed. In ultrathin sections, binding of 36 red blood cells (RBCs) was examined in detail and 3 types of HAD were observed: (1) direct and close binding of RBCs to infected HEp-2 cells (cyto-HAD) was observed in cross sections of 27 RBCs (2...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1977.tb00327.x

    authors: Saburi Y,Okuda K,Takahashi T,Tadokoro I

    更新日期:1977-10-20 00:00:00

  • Neutrophil extracellular Taps play an important role in clearance of Streptococcus suis in vivo.

    abstract::Streptococcus suis infection induces formation of neutrophil extracellular traps (NETs) in vitro; however, the contribution of NETs-mediated killing to the pathogenesis of S. suis in vivo is yet to be elicited. The findings of the present study indicated that extracellular DNA fiber can be induced in a murine model in...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12367

    authors: Zhao J,Lin L,Fu L,Han L,Zhang A

    更新日期:2016-04-01 00:00:00

  • Integration of bovine leukemia virus DNA in the genomes of bovine lymphosarcoma cells.

    abstract::Integration of bovine leukemia virus (BLV) in the genomes of infected cells was investigated in cattle with enzootic bovine leukosis (EBL) and sporadic bovine leukosis (SBL). Southern blot hybridization of BLV cDNA to Eco RI and Xba I restriction fragments of EBL tumor DNAs revealed that: 1) one to four or more copies...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1982.tb00227.x

    authors: Onuma M,Sagata N,Okada K,Ogawa Y,Ikawa Y,Oshima K

    更新日期:1982-01-01 00:00:00

  • Rabbit autoantibodies to actin induced by immunization with modified homologous actins.

    abstract::Actin is a major antigen involved in the reaction of smooth muscle antibody positive sera from patients with chronic active hepatitis. In the present study, actin extracted from rabbit skeletal muscle was denatured by sodium dodecyl sulfate and was immunized into the rabbit, a homologous animal for actin. The rabbits,...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1986.tb03061.x

    authors: Nishioka M,Aibiki T,Shirai M,Terada S,Kagawa H,Watanabe S

    更新日期:1986-01-01 00:00:00

  • In vitro models for analysis of the hepatitis C virus life cycle.

    abstract::Chronic hepatitis C virus (HCV) infection affects approximately 170 million people worldwide. HCV infection is a major global health problem as it can be complicated with liver cirrhosis and hepatocellular carcinoma. So far, there is no vaccine available and the non-specific, interferon (IFN)-based treatments now in u...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1348-0421.2011.00403.x

    authors: Aly HH,Shimotohno K,Hijikata M,Seya T

    更新日期:2012-01-01 00:00:00

  • Differentiation between genera Rhodococcus and Nocardia by susceptibility testing to kanamycin and some other antituberculosis agents.

    abstract::The test for susceptibility to kanamycin is useful for differentiating between the genera Rhodococcus and Nocardia. All rhodococci except R. equi, R. erythropolis, and R. aurantiacus are susceptible to kanamycin, whereas all nocardiae except N. otitidis-caviarum are resistant to kanamycin. Tests for susceptibility to ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1988.tb01404.x

    authors: Tsukamura M

    更新日期:1988-01-01 00:00:00

  • Identification of beta-tubulin isoform V as an autoantigen in allergic rhinitis by a proteomic approach.

    abstract::Autoantibodies to IgE and beta2-adrenergic receptor have been reported in patients with allergic rhinitis. To investigate whether autoimmunity in allergic rhinitis is directed to such limited molecules or directed to a wide range of self proteins, we here attempted to survey autoantigens/autoantibodies comprehensively...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2004.tb03532.x

    authors: Nakamura M,Tsutsumi K,Ooka S,Sekine T,Koizuka I,Nishioka K,Kato T

    更新日期:2004-01-01 00:00:00

  • Effects of cyclophosphamide on the expression and induction of delayed hypersensitivity.

    abstract::Erythematous delayed reactions without induration, presumably assigned to Jones-Mote type, were characterized by the resistance to treatment with cyclophosphamide (CY) before elicitation or immunization in guinea pigs immunized with BGG in IFA or CFA. CY-treatment before elicitation converted delayed erythematous reac...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1978.tb00425.x

    authors: Himeno K,Nomoto K,Takeya K

    更新日期:1978-01-01 00:00:00

  • A unique mutation of glycoprotein gene of the attenuated RC-HL strain of rabies virus, a seed virus used for production of animal vaccine in Japan.

    abstract::Although the RC-HL strain of rabies virus is avirulent in adult mice, the amino acid at position 333 of its G protein is arginine, which is thought to be necessary for virulence in adult mice upon intracerebral inoculation of the virus. This result suggests that besides arginine at position 333, some other positions o...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1994.tb01812.x

    authors: Ito H,Minamoto N,Watanabe T,Goto H,Rong LT,Sugiyama M,Kinjo T,Mannen K,Mifune K,Konobe T

    更新日期:1994-01-01 00:00:00

  • Small ruminant lentiviral Vif proteins commonly utilize cyclophilin A, an evolutionarily and structurally conserved protein, to degrade ovine and caprine APOBEC3 proteins.

    abstract::Mammals have co-evolved with retroviruses, including lentiviruses, over a long period. Evidence supporting this contention is that viral infectivity factor (Vif) encoded by lentiviruses antagonizes the anti-viral action of cellular apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) of the host...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12387

    authors: Yoshikawa R,Izumi T,Nakano Y,Yamada E,Moriwaki M,Misawa N,Ren F,Kobayashi T,Koyanagi Y,Sato K

    更新日期:2016-06-01 00:00:00

  • Oral immunization of mice with Saccharomyces cerevisiae expressing a neutralizing epitope of ApxIIA exotoxin from Actinobacillus pleuropneumoniae induces systemic and mucosal immune responses.

    abstract::An oral delivery system based on ApxIIA#5-expressed on Saccharomyces cerevisiae was studied for its potential to induce immune responses in mice. Murine bone marrow-derived dendritic cells (DCs) stimulated in vitro with ApxIIA#5-expressed on S. cerevisiae upregulated the expression of maturation and activation markers...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12053

    authors: Shin MK,Lee WJ,Jung MH,Cha SB,Shin SW,Yoo A,Kim DH,Yoo HS

    更新日期:2013-06-01 00:00:00

  • B-B cell interactions in the spontaneous activation of B cells in autoimmune NZB mice.

    abstract::We analyzed the mechanism of spontaneous B cell activation in lupus mice by using anticlass-II antibody in vitro. The in vitro culture of B cells from old NZB mice markedly produced Ig without any stimulation, while B cells from NZW mice did not. The addition of anticlass-II antibody (anti-Iad antibody) to the culture...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1991.tb01607.x

    authors: Saito K,Tanaka Y,Ota T,Eto S,Yamashita U

    更新日期:1991-01-01 00:00:00

  • Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A.

    abstract::In recent years, phosphatidylinositol 4-kinase III beta (PI4KB) has emerged as a conserved target of anti-picornavirus compounds. In the present study, PI4KB was identified as the direct target of the plant-derived anti-picornavirus compounds, oxoglaucine and pachypodol (also known as Ro 09-0179). PI4KB was also ident...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12261

    authors: Arita M,Philipov S,Galabov AS

    更新日期:2015-06-01 00:00:00

  • Immunoelectron microscopy of Chlamydia psittaci with monoclonal antibodies.

    abstract::An immunoelectron microscopic study was performed to determine the distribution of antigenic components on particles of Chlamydia psittaci and infected cells using a number of monoclonal antibodies (MAbs). Of three anti-lipopolysaccharide (LPS) antibodies (4D5, A2 and 4G5), two antibodies (4D5 and A2) reacted with the...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1992.tb01648.x

    authors: Ando S,Takashima I,Hashimoto N

    更新日期:1992-01-01 00:00:00

  • Molecular epidemiology of rabies in Vietnam.

    abstract::The present study was done to determine the molecular epidemiology of rabies virus (RV) in Vietnam. The nucleoprotein (N) and glycoprotein (G) genes of RVs were amplified from the brains of ten rabid dogs of Ho Chi Minh City, Vietnam. The nucleotide sequences of these genes were compared with those of other Asian stra...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2007.tb03979.x

    authors: Yamagata J,Ahmed K,Khawplod P,Mannen K,Xuyen DK,Loi HH,Dung NV,Nishizono A

    更新日期:2007-01-01 00:00:00

  • Colonization and turnover of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in otitis-prone children.

    abstract::Recurrent otitis media are frequently intractable during childhood. It is unclear whether recurrent otitis media is caused by etiological bacteria colonization or by new infections. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were isolated from the nasopharynx of 7 otitisprone and 2 non-...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2007.tb03904.x

    authors: Yokota S,Harimaya A,Sato K,Somekawa Y,Himi T,Fujii N

    更新日期:2007-01-01 00:00:00

  • Purine metabolic enzymes in lymphocytes. II. Adenosine deaminase and purine nucleoside phosphorylase activities in the immune response.

    abstract::ICR mice were immunized with sheep red blood cells (sRBC). Both adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) activities in spleen lymphocytes increased faster than the serum antibody titer and reached a peak one week after the immunization. ADA activity increased significantly in T lymphocytes b...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1982.tb00156.x

    authors: Kurashige S,Akuzawa Y,Yoshida T,Teshima C,Kodama K,Mitsuhashi S

    更新日期:1982-01-01 00:00:00

  • Antibody responses raised against a conformational V3 loop peptide of HIV-1.

    abstract::The amino acid sequence of the principal neutralizing determinant (PND) of 224 cases of human immunodeficiency virus type 1 (HIV-1) was determined and the most frequently occurring sequence was used as a peptide antigen for studying virus-specific antibody responses. In our present study, a linear peptide of the most ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1995.tb02249.x

    authors: Bukawa H,Fukushima J,Hamajima K,Kimura M,Tsuji T,Xin KQ,Okuda K

    更新日期:1995-01-01 00:00:00

  • Cell growth and antimicrobial activity of mouse peritoneal macrophages in response to glucocorticoids, choleragen and lipopolysaccharide.

    abstract::Normal, thioglycollate-stimulated and BCG-activated mouse peritoneal macrophages were cultivated in vitro with the conditioned medium of mouse L-929 cells. The thioglycollate- and BCG-macrophages rapidly proliferated, whereas normal macrophages grew more slowly. A clear morphological difference between the three types...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1980.tb02924.x

    authors: Nozawa RT,Yanaki N,Yokota T

    更新日期:1980-01-01 00:00:00

  • Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication.

    abstract::Japanese encephalitis virus (JEV) core protein is detected not only in the cytoplasm but also in the nucleoli of infected cells. We previously showed that a mutant JEV lacking the nucleolar localization of the core protein impaired viral replication in mammalian cells. In this study, we identified a nucleolar phosphop...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2006.tb03789.x

    authors: Tsuda Y,Mori Y,Abe T,Yamashita T,Okamoto T,Ichimura T,Moriishi K,Matsuura Y

    更新日期:2006-01-01 00:00:00

  • Improvements of PCR-based identification targeting the DNA topoisomerase II gene to determine major species of the opportunistic fungi Candida and Aspergillus fumigatus.

    abstract::For the simple and rapid detection/identification of major pathogenic fungal species such as Candida albicans, C. tropicalis, C. parapsilosis, C. glabrata and Aspergillus fumigatus, common primers for these species and specific primers for each species, designed on the basis on the genomic nucleotide sequences of the ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2003.tb03426.x

    authors: Kanbe T,Arishima T,Horii T,Kikuchi A

    更新日期:2003-01-01 00:00:00

  • Selective and differential media for isolation and tentative identification of each species of Pityrosporum residing on normal or diseased human skin.

    abstract::Selective and differential media were designed for each species of Pityrosporum; P. pachydermatis, P. ovale, and P. orbiculare in order to make feasible a quantitative cultivation. Medium for P. pachydermatis (medium A) was composed of 1% trypticase peptone (BBL), 0.5% yeast extract (BBL), 0.3% glucose, 0.2% NaCl, 1.2...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1981.tb00119.x

    authors: Ushijima T,Takahashi M,Ozaki Y

    更新日期:1981-01-01 00:00:00

  • Histopathological studies of reactions in mice injected with aluminum-adsorbed tetanus toxoid.

    abstract::Histopathological observations of changes at the injection site in mice were made for 20 weeks after a single intramuscular (im) injection of aluminum hydroxide-adsorbed tetanus toxoid (Alum-TT), plain tetanus toxoid (TT), or aluminum adjuvant (Alum alone). Marked injury to muscle fibers and infiltration of neutrophil...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1982.tb00261.x

    authors: Goto N,Akama K

    更新日期:1982-01-01 00:00:00

  • The fibronectin-binding protein homologue Fbp62 of Streptococcus anginosus is a potent virulence factor.

    abstract::Streptococcus anginosus appears to be able to adhere to cultured epithelial cells or fibronectin and this may be associated with bacterial pathogenicity. In the present study, the molecular characteristics and virulence of the fibronectin-binding protein (FBP), Fbp62, of S. anginosus were investigated in animal models...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12646

    authors: Kodama Y,Ishikawa T,Shimoyama Y,Sasaki D,Kimura S,Sasaki M

    更新日期:2018-10-01 00:00:00

  • Antigenic variation of Newcastle disease viruses isolated from wild ducks in Japan.

    abstract::Nineteen strains of Newcastle disease virus (NDV) isolated from wild ducks in Japan were placed into 4 distinct antigenic groups on the basis of their reactivities to 8 monoclonal antibodies against the HN molecule of NDV in hemagglutination inhibition tests. The NDV strains of duck origin were antigenically distinct ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1987.tb03144.x

    authors: Kawamura M,Nagata-Matsubara K,Nerome K,Yamane N,Kida H,Kodama H,Izawa H,Mikami T

    更新日期:1987-01-01 00:00:00

  • Quantitative analysis of cereulide, an emetic toxin of Bacillus cereus, by using rat liver mitochondria.

    abstract::An emetic toxin cereulide, produced by Bacillus cereus, causes emetic food poisonings, but a method for quantitative measurement of cereulide has not been well established. A current detection method is a bioassay method using the HEp-2 cell vacuolation test, but it was unable to measure an accurate concentration. We ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2005.tb03636.x

    authors: Kawamura-Sato K,Hirama Y,Agata N,Ito H,Torii K,Takeno A,Hasegawa T,Shimomura Y,Ohta M

    更新日期:2005-01-01 00:00:00

  • Enhancement of Newcastle disease virus-induced fusion of mouse L cells by sodium vanadate.

    abstract::Sodium vanadate enhanced Newcastle disease virus (NDV)-induced cell fusion in L cells, and there was a direct correlation between the degree of cell fusion and the dose of vanadate added. When anti-F protein of NDV monospecific antiserum was added to the culture fluid of L cells infected with NDV, the enhancement of c...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1984.tb02948.x

    authors: Yamamoto F,Fujioka H,Iinuma M,Takano M,Maeno K,Nagai Y,Ito Y

    更新日期:1984-01-01 00:00:00

  • A highly effective method for removing suspended poliovirus from water using a positively-charged carbon felt electrode.

    abstract::We developed an effective system to eliminate poliovirus from modified tap water using a positively-charged carbon felt electrode. The zeta potential of polioviruses was measured using laser microscopic electrophoresis. Poliovirus adsorption to the electrode was examined by indirect immunofluorescence. The tissue cult...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2004.tb03557.x

    authors: Kondo Y,Morita Y,Yamada A,Kimura H

    更新日期:2004-01-01 00:00:00

  • Effects of dextran sulfate 500 on protective responses to sublethal Trichomonas foetus infection in mice.

    abstract::In order to analyze the host-parasite interactions in experimental trichomoniasis, the growth of Trichomonas foetus in the peritoneal cavity and changes in the peritoneal exudate cells were followed in mice treated with dextran sulfate 500 (DS 500), a known macrophage-toxic agent. Light microscopic observation showed ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1980.tb02898.x

    authors: Oka Y,Hayashi H,Ishikawa F,Osaki H

    更新日期:1980-01-01 00:00:00