Abstract:
:Photodynamic therapy (PDT) has been considered a feasible alternative for antimicrobial therapy of multidrug-resistant pathogens. However, bacterial response mechanisms against PDT-generated photo-oxidative stress remain largely unknown. Herein, it is shown that the accessory gene regulator Agr is involved in Staphylococcus aureus response to photo-oxidative stress generated by laser-induced PDT with the photosensitizer chlorin e6 . Transcriptional profiling revealed that sublethal PDT induces a general stress response and also activates Agr-dependent gene regulation. Moreover, mutant S. aureus lacking Agr function showed hypersusceptibility to two independent PDT conditions with higher energy densities, demonstrating Agr-dependent S. aureus resistance against PDT.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Park HJ,Moon YH,Yoon HE,Park YM,Yoon JH,Bang ISdoi
10.1111/1348-0421.12070subject
Has Abstractpub_date
2013-08-01 00:00:00pages
547-52issue
8eissn
0385-5600issn
1348-0421journal_volume
57pub_type
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