Neutrophil extracellular Taps play an important role in clearance of Streptococcus suis in vivo.

Abstract:

:Streptococcus suis infection induces formation of neutrophil extracellular traps (NETs) in vitro; however, the contribution of NETs-mediated killing to the pathogenesis of S. suis in vivo is yet to be elicited. The findings of the present study indicated that extracellular DNA fiber can be induced in a murine model in response to S. suis infection. A nuclease that destroys their structure was used to evaluate the role of NETs on S. suis infection. Treatment with nuclease resulted in a greater bacteria load and higher serum TNF-α concentrations in response to S. suis infection, indicating that NETs structure played an essential role in S. suis clearance and inflammation. Furthermore, nuclease treatment resulted in more severe clinical signs during and higher mortality from S. suis infection. These findings indicated that NETs structure contributes to protection against S. suis infection.

journal_name

Microbiol Immunol

authors

Zhao J,Lin L,Fu L,Han L,Zhang A

doi

10.1111/1348-0421.12367

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

228-33

issue

4

eissn

0385-5600

issn

1348-0421

journal_volume

60

pub_type

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