Abstract:
:Streptococcus suis infection induces formation of neutrophil extracellular traps (NETs) in vitro; however, the contribution of NETs-mediated killing to the pathogenesis of S. suis in vivo is yet to be elicited. The findings of the present study indicated that extracellular DNA fiber can be induced in a murine model in response to S. suis infection. A nuclease that destroys their structure was used to evaluate the role of NETs on S. suis infection. Treatment with nuclease resulted in a greater bacteria load and higher serum TNF-α concentrations in response to S. suis infection, indicating that NETs structure played an essential role in S. suis clearance and inflammation. Furthermore, nuclease treatment resulted in more severe clinical signs during and higher mortality from S. suis infection. These findings indicated that NETs structure contributes to protection against S. suis infection.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Zhao J,Lin L,Fu L,Han L,Zhang Adoi
10.1111/1348-0421.12367subject
Has Abstractpub_date
2016-04-01 00:00:00pages
228-33issue
4eissn
0385-5600issn
1348-0421journal_volume
60pub_type
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