Overexpression of complement receptor type I (CR1, CD35) on erythrocytes in patients with hemoplasma infection.

Abstract:

:In the present study, 12 patients with fever of undetermined origin, anemia and icterus were diagnosed with hemoplasma infection by light microscopy, transmission electron microscopy examination and PCR assay after being excluded from other usual febrile diseases. Complement receptor type I (CR1, CD35) expression on the surface of erythrocytes was assessed by flow cytometry using mouse anti-human CD35 antibody. Compared with healthy volunteers, the level of CD35 was significantly elevated in patients with severe hemoplasma infection at diagnosis, and decreased sharply after treatment. However, in latent infection cases without clinical manifestations, CD35 expression showed an ascending trend but had no statistical difference compared to the healthy controls. The present study demonstrated that hemoplasma infection can induce high levels of expression of CR1 on the membrane of red blood cells, which may be a reaction to the immunity challenge.

journal_name

Microbiol Immunol

authors

Congbin Y,Aibin L,Congli Y,Juan X,Lanjun B,Weiping Z,Zhibiao Y,Xiuguo H

doi

10.1111/j.1348-0421.2010.00240.x

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

460-5

issue

8

eissn

0385-5600

issn

1348-0421

pii

MIM240

journal_volume

54

pub_type

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