Abstract:
:ISG20 is an ribonuclease specific for single-stranded RNA and considered to play a role in innate immunity against virus infections. We herein show that both poly IC, an authentic double-stranded RNA, and IFN-gamma induced ISG20 expression in cultured HUVEC. Poly IC-induced ISG20 expression was inhibited by LY294002, an inhibitor of PI3K, or by RNA interference against IFN regulatory factor three. ISG20 expression was not induced by IFN-beta, loxoribine or CpG oligonucleotide. These results suggest that ISG20 induction by poly IC may not be dependent on the IRF-3-mediated type I IFN induction pathway in HUVEC. ISG20 may be involved in innate immunity against viral infection in vascular endothelial cells.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Imaizumi T,Mechti N,Matsumiya T,Sakaki H,Kubota K,Yoshida H,Kimura H,Satoh Kdoi
10.1111/j.1348-0421.2008.00004.xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
30-5issue
1eissn
0385-5600issn
1348-0421pii
MIM004journal_volume
52pub_type
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