A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection.

Abstract:

:Irradiation treatment enhanced resistance of C57BL/6, but not BALB/c against Toxoplasma gondii infection. Six Gy-irradiated (IR) C57BL/6 recipients of B-2 cells from T. gondii-infected C57BL/6 died after infection. B-2 suppressor cells from infected C57BL/6 enhanced production of IL-4 and IL-10 in peritoneal exudate cells (PECs), and down-regulated NO release in peritoneal macrophages after infection. On the other hand, B-2 suppressor cells were not detected in a strain, BALB/c, resistant against infection. These data indicated that irradiation-sensitive B-2 cells regulated susceptibility/resistance in mice against T. gondii infection.

journal_name

Microbiol Immunol

authors

Mun HS,Aosai F,Fang H,Piao LX,Winn T,Norose K,Yano A

doi

10.1111/j.1348-0421.2005.tb03674.x

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

853-8

issue

9

eissn

0385-5600

issn

1348-0421

pii

JST.JSTAGE/mandi/49.853

journal_volume

49

pub_type

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