Infection of J774A.1 with different Mycobacterium species induces differential immune and miRNA-related responses.

Abstract:

:Macrophages act as a reservoir for Mycobacterium tuberculosis, producing latent infection in approximately 90% of infected people. In this study, J774A.1 mouse macrophage cell line response and microRNA (miRNA) expression during infection with the most relevant mycobacterial strains for humans (M. tuberculosis, M. bovis and M. bovis BCG) was explored. No significant differences in bacillary loads were observed between activate and naive macrophages infected with M. tuberculosis and M. bovis. Nitrite production inhibition and infection control were in accordance with the virulence of the strain. Expression of let-7e, miR-21, miR-155, miR-210 and miR-223 was opposite in the two species and miR-146b* and miR-1224 expression seemed to be part of the general response to infection.

journal_name

Microbiol Immunol

authors

Elizabeth MC,Hernández de la Cruz ON,Mauricio CA

doi

10.1111/1348-0421.12380

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

356-63

issue

5

eissn

0385-5600

issn

1348-0421

journal_volume

60

pub_type

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