Minimal contribution of Valpha14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice.

Abstract:

:We elucidated the contribution of Valpha14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Valpha14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-gamma between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Valpha14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.

journal_name

Microbiol Immunol

authors

Kawakami K,Kinjo Y,Uezu K,Yara S,Miyagi K,Koguchi Y,Nakayama T,Taniguchi M,Saito A

doi

10.1111/j.1348-0421.2002.tb02687.x

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

207-10

issue

3

eissn

0385-5600

issn

1348-0421

journal_volume

46

pub_type

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