Roles of the interactions between Env and Gag proteins in the HIV-1 replication cycle.

Abstract:

:The Env and Gag proteins of HIV-1 are the two major structural proteins of this retrovirus. The interactions between Env and Gag proteins and their regulation in HIV-1 are required for several steps of the replication cycle, involving not only virus assembly, specifically Env incorporation, but also entry steps after virus maturation. A large number of host factors and certain membrane microdomains appear to engage both in transport/trafficking of Env and/or Gag proteins, and in the interactions of these two proteins. The present review briefly summarizes our current knowledge regarding the roles of the interactions between Env and Gag proteins in the virus replication cycle.

journal_name

Microbiol Immunol

authors

Murakami T

doi

10.1111/j.1348-0421.2008.00008.x

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

287-95

issue

5

eissn

0385-5600

issn

1348-0421

pii

MIM008

journal_volume

52

pub_type

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