Abstract:
:Four N-acetylchito-oligosaccharides, from tetra-N-acetylchitotetraose (NACOS-4) to hepta-N-acetylchitoheptaose (NACOS-7), were found to increase the number of peritoneal exudate cells (PEC) in male BALB/c mice after 3 hr intraperitoneal administration of 50 mg/kg of each oligosaccharide. The number of attracted cells, consisting largely of polymorphonuclear leukocytes (PMN), was proportional to the molecular weights of the administered oligosaccharides, except for NACOS-7 which displayed the same activity as NACOS-6. In an in vitro chemotaxis assay using normal mouse leukocytes, it was found that NACOS-6 displayed stronger effects than muramyl dipeptide. The PEC from NACOS-6 treated mice showed a higher active oxygen-generating activity. PMN from normal mouse peripheral blood were also shown to have enhanced active oxygen-generating activity in vitro. PEC from NACOS-6 treated mice were shown to possess strong candidacidal activity in vitro.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Suzuki K,Tokoro A,Okawa Y,Suzuki S,Suzuki Mdoi
10.1111/j.1348-0421.1986.tb03004.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
777-87issue
8eissn
0385-5600issn
1348-0421journal_volume
30pub_type
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