Induction of protective immunity by primed B-1 cells in Toxoplasma gondii -infected B cell-deficient mice.

Abstract:

:We examined the role of B-1 cells in protection against Toxoplasma gondii infection using B cell-deficient mice (muMT mice). We found that primed but not naïve B-1 cells from wild-type C57BL/6 mice protected B cell-deficient recipients from challenge infection. All muMT mice transferred with primed B-1 cells survived more than 5 months after T. gondii infection, whereas 100% of muMT mice transferred with naïve B-1 cells succumbed by 18 days after infection. Additionally, high expression of both T help (Th) 1- and Th2-type cytokines and a high level of nitric oxide production were observed in T. gondii-infected muMT mice transferred with primed B-1 cells. Thus, it was clearly demonstrated that B-1 cells play an important role in host protection against T. gondii infection in muMT mice.

journal_name

Microbiol Immunol

authors

Chen M,Mun HS,Piao LX,Aosai F,Norose K,Mohamed RM,Belal US,Fang H,Ahmed AK,Kang HK,Matsuzaki G,Kitamura D,Yano A

doi

10.1111/j.1348-0421.2003.tb03460.x

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

997-1003

issue

12

eissn

0385-5600

issn

1348-0421

journal_volume

47

pub_type

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