Effects of dextran sulfate 500 on protective responses to sublethal Trichomonas foetus infection in mice.

Abstract:

:In order to analyze the host-parasite interactions in experimental trichomoniasis, the growth of Trichomonas foetus in the peritoneal cavity and changes in the peritoneal exudate cells were followed in mice treated with dextran sulfate 500 (DS 500), a known macrophage-toxic agent. Light microscopic observation showed that DS 500 treatment induced degeneration of peritoneal macrophages within about 48 hr after the treatment and the damaged macrophages did not phagocytize the parasites, whereas peritoneal neutrophils and lymphocytes were not affected by the drug. In the DS 500-treated mice, growth of parasites in the peritoneal cavity was accelerated and a high susceptibility of the mice to T. foetus infection was observed. These results indicate that macrophages play the most important role among the peritoneal exudate cells in resistance to T. foetus infection, especially during the early stage of infection.

journal_name

Microbiol Immunol

authors

Oka Y,Hayashi H,Ishikawa F,Osaki H

doi

10.1111/j.1348-0421.1980.tb02898.x

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

925-32

issue

10

eissn

0385-5600

issn

1348-0421

journal_volume

24

pub_type

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