Antibacterial activity of cefpodoxime against Branhamella catarrhalis.

Abstract:

:The antibacterial activity of cefpodoxime against Branhamella catarrhalis was studied. All of the 65 clinical isolates tested were inhibited at and below 1.56 micrograms/ml, both at 10(7) and at 10(5) CFUs. The following was further studied on B. catarrhalis N-5 which showed average susceptibility to each drug examined. Bactericidal activity was observed at and above the MIC. Scanning and transmission electron microscopy revealed morphological changes, such as cellular swelling, bleb formation, inhibition of septum formation, and lysis, of the cells exposed to cefpodoxime at concentrations around the MIC. Cefpodoxime was poorly hydrolyzed by the beta-lactamase and it showed affinity for two penicillin-binding proteins that had approximate molecular weights of 83 and 74 kilodaltons, with I50 values of 3.7 and 2.1 micrograms/ml, respectively.

journal_name

Microbiol Immunol

authors

Takenouchi T,Nishino T

doi

10.1111/j.1348-0421.1991.tb01628.x

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

1059-71

issue

12

eissn

0385-5600

issn

1348-0421

journal_volume

35

pub_type

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