Abstract:
:A cytotoxic T lymphocyte (CTL) response to dengue virus-infected target cells is described. Effector cells were generated in an in vitro secondary culture and appeared to be T cells possessing both the Lyt 1.1 and Lyt 2.1 surface antigens. A stronger CTL response was noted with the H-2k haplotype compared to H-2d, and H-2 compatibility was required between CTL and target cells. CTL generated showed some cross-reactivity with target cells infected with Japanese encephalitis virus (JEV), another flavivirus, but not with target cells infected with an alphavirus, Sindbis. The significance and importance of these findings are discussed.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Pang T,Devi S,Blanden RV,Lam SKdoi
10.1111/j.1348-0421.1988.tb01411.xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
511-8issue
5eissn
0385-5600issn
1348-0421journal_volume
32pub_type
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journal_title:Microbiology and immunology
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