Abstract:
:The killing activity of cord blood mononuclear cells (cMNC) against cytomegalovirus (CMV)-uninfected and -infected fibroblasts was comparable to that of adult peripheral blood mononuclear cells (aPBMC). The killing activity of cMNC against K562 cells was significantly lower compared with that of aPBMC. Treatment of cMNC and aPBMC with interleukin-2 (IL-2), IL-12 or IL-15 significantly enhanced killing activity against K562 cells and CMV-uninfected and -infected cells. By comparison of cMNC with aPBMC, killing activity against the K562 cells of cMNC was augmented to the level of aPBMC when cultured with IL-2, IL-12 or IL-15. The killing activity of cMNC against CMV-uninfected and -infected fibroblasts did not increase to the level of adult PBMC by treatment with IL-2, IL-12 or IL-15. These data suggest that cord blood contains a functionally different NK cell subpopulation than that among adult NK cells.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Hoshina T,Kida K,Ito Mdoi
10.1111/j.1348-0421.1999.tb02387.xkeywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
161-6issue
2eissn
0385-5600issn
1348-0421journal_volume
43pub_type
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