Herpes simplex virus US3 protein kinase regulates host responses and determines neurovirulence.

Abstract:

:The US3 of HSV encodes a serine/threonine protein kinase that is highly conserved among members of the alphaherpesviruses. It is an accessory gene that is not required for viral replication in cultured cells but appears essential for viral survival in humans. Although accumulating in vitro evidence suggested that the viral protein kinase is multifunctional, little information is available about its functions in vivo. Several reports point out that, upon invasion into the peripheral nervous system, HSV blocks virus-induced neuronal apoptosis, while presumably subverting host immune responses, largely through actions of the US3 protein kinase. In addition, the US3 protein kinase confers the viral neurovirulence. In the present article, functions of the HSV US3 protein kinase are briefly reviewed, with special attention given to its role in regulating host responses and neurovirulence.

journal_name

Microbiol Immunol

authors

Mori I

doi

10.1111/j.1348-0421.2012.00461.x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

351-5

issue

6

eissn

0385-5600

issn

1348-0421

journal_volume

56

pub_type

杂志文章,评审
  • Moraxella catarrhalis does not grow on nutrient agar without sodium chloride supplementation.

    abstract::None of the 58 Moraxella catarrhalis strains grew on nutrient agar without sodium chloride supplementation, whereas 49 of 51 commensal Neisseria spp. strains tested did. Growth on nutrient agar without sodium chloride supplementation could be used for screening between M. catarrhalis and commensal Neisseria spp. ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2005.tb03645.x

    authors: Chida T,Sawabe E,Ono E,Nishiyama H,Ebina K,Sato K,Watanabe Y,Kuroki T,Okamura N

    更新日期:2005-01-01 00:00:00

  • The role of p38 mitogen-activated protein kinase in regulating interleukin-10 gene expression in Burkitt's lymphoma cell lines.

    abstract::In malignant B lymphoma cells interleukin-10 (IL-10) expression is frequently upregulated. This effect is thought to support to the malignant transformation of these cells and to be a potential target for pharmacotherapy. To define better the mechanism for upregulation of the IL-10 gene, we tested the association betw...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2007.tb03885.x

    authors: Horie K,Ohashi M,Satoh Y,Sairenji T

    更新日期:2007-01-01 00:00:00

  • Functional analysis of the type III secretion system in enteropathogenic Escherichia coli O157:H45.

    abstract::A mass outbreak of Escherichia coli O157:H45 was first reported in Japan in 1998. This pathogen was classified as an enteropathogenic E. coli (EPEC) O157 because it was characterized by the Shiga toxin gene (stx)-negative and bundle-forming pilus (bfp) gene-positive genotypes. In this study, we investigated the type I...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2000.tb02574.x

    authors: Abe A,Nagano H

    更新日期:2000-01-01 00:00:00

  • Immunoelectron microscopy of Chlamydia psittaci with monoclonal antibodies.

    abstract::An immunoelectron microscopic study was performed to determine the distribution of antigenic components on particles of Chlamydia psittaci and infected cells using a number of monoclonal antibodies (MAbs). Of three anti-lipopolysaccharide (LPS) antibodies (4D5, A2 and 4G5), two antibodies (4D5 and A2) reacted with the...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1992.tb01648.x

    authors: Ando S,Takashima I,Hashimoto N

    更新日期:1992-01-01 00:00:00

  • Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes.

    abstract::Borna disease virus (BoDV), a prototype of mammalian bornavirus, is a non-segmented, negative strand RNA virus that often causes severe neurological disorders in infected animals, including horses and sheep. Unique among animal RNA viruses, BoDV transcribes and replicates non-cytopathically in the cell nucleus, leadin...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12505

    authors: Fujino K,Yamamoto Y,Daito T,Makino A,Honda T,Tomonaga K

    更新日期:2017-09-01 00:00:00

  • Macrophage migration inhibitory factor (MIF) produced by a human T cell hybridoma clone.

    abstract::A human T cell hybridoma clone, F5, producing high levels of macrophage migration inhibitory factor (MIF) was established by the emetine-actinomycin D selection method. This clone produced two species of MIF which were separated on a Phenyl Sepharose column. We purified MIF-2 (the more hydrophobic species of the two) ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1991.tb01552.x

    authors: Hirose S,Ooki S,Higuchi M,Osawa T

    更新日期:1991-01-01 00:00:00

  • IgM induction in murine B hybridomas with Ia-restricted T cell clones: a monoclonal model for T and B cell interactions in antibody response.

    abstract::The mechanism of MHC-restricted T and B cell interactions in antibody response was studied with IgM-inducible B hybridomas and antigen-specific helper T cell clones. B hybridomas were prepared by fusion between splenic B cells from (CBA/N (H-2k) X BALB/c (H-2d)) F1 (NBF1) male mice and a B lymphoma cell line, M12.4.5....

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1985.tb02963.x

    authors: Yoshikubo T,Kimoto M,Kishimoto T

    更新日期:1985-01-01 00:00:00

  • Isolation and characterization of Mycoplasma and Acholeplasma from apparently healthy and diseased (infectious sinusitis) turkeys.

    abstract::Investigation of 136 turkeys (24 manifesting infra-orbital sinusitis, 112 apparently healthy) resulted in isolation of 79 strains of Mycoplasma and 4 of Acholeplasma. By the disc growth inhibition test with 16 reference antisera of avian serogroups, 55 strains were identified serologically and 28 remained unidentified...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1981.tb00067.x

    authors: El Sayed SA,Chandiramani NK,Garg DN

    更新日期:1981-01-01 00:00:00

  • Experimental infection of specific-pathogen-free mice with enterohemorrhagic Escherichia coli O157:H7.

    abstract::By subcutaneous inoculation of 10(8) CFU of enterohemorrhagic E. coli O157:H7, specific-pathogen-free mice revealed most of the symptoms and histological changes observed in patients. The histological changes in intestine were mainly seen in the distal parts of small intestine and the cecum. Vacuolation of villi in th...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1991.tb01582.x

    authors: Lai XH,Xu JG,Liu BY

    更新日期:1991-01-01 00:00:00

  • The presence of antibodies against the AD2 epitope of cytomegalovirus glycoprotein B is associated with acute rejection after renal transplantation.

    abstract::The aim of this study was to evaluate the association between antibodies against cytomegalovirus (CMV) glycoprotein B (gB) and acute rejection after transplantation. Seventy-seven consecutive renal transplant recipients in a D + /R+ setting were studied. Biopsy-proven rejection occurred in 35% of the recipients. Among...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12112

    authors: Ishibashi K,Tokumoto T,Shirakawa H,Oguro T,Yanagida T,Takahashi N,Nomiya M,Haga N,Aikawa K,Tanabe K,Inoue N,Kojima Y,Suzutani T

    更新日期:2014-01-01 00:00:00

  • Agr function is upregulated by photodynamic therapy for Staphylococcus aureus and is related to resistance to photodynamic therapy.

    abstract::Photodynamic therapy (PDT) has been considered a feasible alternative for antimicrobial therapy of multidrug-resistant pathogens. However, bacterial response mechanisms against PDT-generated photo-oxidative stress remain largely unknown. Herein, it is shown that the accessory gene regulator Agr is involved in Staphylo...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12070

    authors: Park HJ,Moon YH,Yoon HE,Park YM,Yoon JH,Bang IS

    更新日期:2013-08-01 00:00:00

  • Characterization of multi-layered membrane generated by rabies virus.

    abstract::Electron microscopy revealed multi-layered membranes within the cytoplasmic inclusion (accumulation of nucleocapsids) produced by rabies virus. When infected BHK cells were maintained at 31 C, an enhancement in production of these membranes occurred in approximately 60% of inclusion-containing cells. Multi-layered mem...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1979.tb00518.x

    authors: Tanabe K,Matsumoto S

    更新日期:1979-01-01 00:00:00

  • Detection of Coxiella burnetii from dust in a barn housing dairy cattle.

    abstract::We attempted to detect Coxiella burnetii in dust samples collected from a barn housing dairy cattle by the polymerase chain reaction (PCR) method. Ten dust samples (five from ventilation fans and five from crossbeams) were collected from two areas in a barn on a farm near Sapporo, Hokkaido. C. burnetii was detected in...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1998.tb01969.x

    authors: Yanase T,Muramatsu Y,Inouye I,Okabayashi T,Ueno H,Morita C

    更新日期:1998-01-01 00:00:00

  • Detection of Clostridium difficile toxin A by reversed passive latex agglutination.

    abstract::A reversed passive latex agglutination (RPLA) assay for detecting Clostridium difficile toxin A is presented. Purified monoclonal antibody (mAb 37B5) was used for latex sensitization. The culture supernatants of 93 strains of C. difficile were tested by RPLA assay and the results compared with those of a commercially ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1999.tb02464.x

    authors: Toma C,Nakamura S,Kamiya S,Nakasone N,Iwanaga M

    更新日期:1999-01-01 00:00:00

  • WT1 peptide-based immunotherapy for patients with lung cancer: report of two cases.

    abstract::The Wilms' tumor gene WT1 is overexpressed in various types of solid tumors, including lung and breast cancer and WT1 protein is a tumor antigen for these malignancies. In phase I clinical trials of WT1 peptide-based cancer immunotherapy, two patients with advanced lung cancer were intradermally injected with 0.3 mg o...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2004.tb03503.x

    authors: Tsuboi A,Oka Y,Osaki T,Kumagai T,Tachibana I,Hayashi S,Murakami M,Nakajima H,Elisseeva OA,Fei W,Masuda T,Yasukawa M,Oji Y,Kawakami M,Hosen N,Ikegame K,Yoshihara S,Udaka K,Nakatsuka S,Aozasa K,Kawase I,Sugiyama H

    更新日期:2004-01-01 00:00:00

  • Zymographic characterization of bacteriolytic enzymes produced by oral streptococci.

    abstract::Zymographic analysis was performed to know the bacteriolytic enzyme profiles of 4% SDS extracts of oral streptococci, Streptococcus mutans, S. sobrinus, S. sanguis, S. mitis and S. salivarius. We investigated the five strains in each species and found that the profile was very similar among strains of the same species...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2004.tb03537.x

    authors: Yoshimura G,Komatsuzawa H,Kajimura J,Fujiwara T,Ohara M,Kozai K,Sugai M

    更新日期:2004-01-01 00:00:00

  • Multigenic relation to the attenuation of rabies virus.

    abstract::Rabies virus Nishigahara strain causes lethal infection in adult mice after intracerebral inoculation. On the other hand, the RC-HL strain, derived from the Nishigahara strain, does not cause lethal infection in adult mice. We previously demonstrated that a chimeric virus, R(G), with the open reading frame of the G ge...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2006.tb03767.x

    authors: Yamada K,Ito N,Takayama-Ito M,Sugiyama M,Minamoto N

    更新日期:2006-01-01 00:00:00

  • Analysis of cytokine producing activity of intestinal intraepithelial T cells from TCR beta-chain and delta-chain mutant mice.

    abstract::Intestinal intraepithelial T cells (IELs) expressing either gammadelta TCR or alphabeta TCR have been proposed to play an important role in the regulation of intestinal epithelia by producing cytokines that directly influence the adjoining intestinal epithelial cell (IEC) functions. To illuminate this issue, we utiliz...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1997.tb01212.x

    authors: Kohyama M,Hachimura S,Nanno M,Ishikawa H,Kaminogawa S

    更新日期:1997-01-01 00:00:00

  • Differentiation between genera Rhodococcus and Nocardia by susceptibility testing to kanamycin and some other antituberculosis agents.

    abstract::The test for susceptibility to kanamycin is useful for differentiating between the genera Rhodococcus and Nocardia. All rhodococci except R. equi, R. erythropolis, and R. aurantiacus are susceptible to kanamycin, whereas all nocardiae except N. otitidis-caviarum are resistant to kanamycin. Tests for susceptibility to ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1988.tb01404.x

    authors: Tsukamura M

    更新日期:1988-01-01 00:00:00

  • Facilitated production of secretory IgA against Shiga toxin B subunits by intranasal application of antigen-coated polystyrene microspheres.

    abstract::We examined the effects of microspheres as antigen carriers in mucosal immunization. Shiga toxin B subunits (Stx1B) were adsorbed on 6 mum polystyrene microspheres, which were then intranasally administered to mice together with cholera toxin (CT). Stx1B-specific serum IgG production and secretory IgA production at lo...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2005.tb03714.x

    authors: Kurohane K,Kobayashi C,Imai Y

    更新日期:2005-01-01 00:00:00

  • Purification and characterization of heat-labile toxin from Bordetella bronchiseptica.

    abstract::The heat-labile toxin (HLT) of Bordetella bronchiseptica was purified successively from sonic extracts of phase I organisms grown in Stainer-Scholte medium, by partition in hydrophobic interaction, sucrose density gradient centrifugation, gel filtration through Sepharose 4B and 6B, isoelectric precipitation and isoele...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1986.tb02992.x

    authors: Endoh M,Amitani M,Nakase Y

    更新日期:1986-01-01 00:00:00

  • Quantification of the CD55 and CD59, membrane inhibitors of complement on HIV-1 particles as a function of complement-mediated virolysis.

    abstract::Previous studies have demonstrated that the murine monoclonal antibody (MoAb) NM-01 activates the human complement classical pathway resulting in lysis of human immunodeficiency virus (HIV). The present study was performed to determine the availability of the V3-loop of gp120 relative to the complement regulatory prot...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1996.tb01109.x

    authors: Nakamura M,Okada H,Sasaki H,Yoshida K,Kamada M,Okada N,Terada M,Ohno T

    更新日期:1996-01-01 00:00:00

  • Analysis of the structural gene encoding a hemolysin in Vibrio mimicus.

    abstract::An environmental isolate of V. mimicus, strain E-33, has been reported to produce and secrete a hemolysin of 63 kDa. The hemolysin is enterotoxic in test animals. The nucleotide sequence of the structural gene of the hemolysin was determined. We found a 2,232 bp open reading frame, which codes a peptide of 744 amino a...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1997.tb01183.x

    authors: Rahman MM,Miyoshi S,Tomochika K,Wakae H,Shinoda S

    更新日期:1997-01-01 00:00:00

  • A novel B-2 suppressor cell regulating susceptibility/resistance of mice to Toxoplasma gondii infection.

    abstract::Irradiation treatment enhanced resistance of C57BL/6, but not BALB/c against Toxoplasma gondii infection. Six Gy-irradiated (IR) C57BL/6 recipients of B-2 cells from T. gondii-infected C57BL/6 died after infection. B-2 suppressor cells from infected C57BL/6 enhanced production of IL-4 and IL-10 in peritoneal exudate c...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2005.tb03674.x

    authors: Mun HS,Aosai F,Fang H,Piao LX,Winn T,Norose K,Yano A

    更新日期:2005-01-01 00:00:00

  • Oral immunization of mice with Saccharomyces cerevisiae expressing a neutralizing epitope of ApxIIA exotoxin from Actinobacillus pleuropneumoniae induces systemic and mucosal immune responses.

    abstract::An oral delivery system based on ApxIIA#5-expressed on Saccharomyces cerevisiae was studied for its potential to induce immune responses in mice. Murine bone marrow-derived dendritic cells (DCs) stimulated in vitro with ApxIIA#5-expressed on S. cerevisiae upregulated the expression of maturation and activation markers...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12053

    authors: Shin MK,Lee WJ,Jung MH,Cha SB,Shin SW,Yoo A,Kim DH,Yoo HS

    更新日期:2013-06-01 00:00:00

  • Epidemiological study on infectious diarrheal diseases in children in a coastal rural area of Kenya.

    abstract::Diarrheal diseases are major causes of morbidity and mortality among children in developing countries. We have analyzed the causative agents of diarrhea in children under five years of age who resided in rural environments but attended a hospital in Malindi, a coastal town in Kenya. Bacterial diarrhea was found in 239...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1997.tb01925.x

    authors: Saidi SM,Iijima Y,Sang WK,Mwangudza AK,Oundo JO,Taga K,Aihara M,Nagayama K,Yamamoto H,Waiyaki PG,Honda T

    更新日期:1997-01-01 00:00:00

  • Virological surveillance of human influenza in Indonesia, October 2008-March 2010.

    abstract::Despite the high prevalence of highly pathogenic H5N1 influenza A viruses in Indonesia, epidemiology information on seasonal human influenza is lacking. The present authors, therefore, conducted virologic surveillance in Surabaya, East Java from October 2008 to March 2010. Influenza viruses, including pandemic (H1N1) ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2011.00344.x

    authors: Yamaoka M,Palilingan JF,Wibisono J,Yudhawati R,Nidom RV,Alamudi MY,Ginting TE,Makino A,Nidom CA,Shinya K,Kawaoka Y

    更新日期:2011-07-01 00:00:00

  • T cell-mediated cytotoxicity against dengue-infected target cells.

    abstract::A cytotoxic T lymphocyte (CTL) response to dengue virus-infected target cells is described. Effector cells were generated in an in vitro secondary culture and appeared to be T cells possessing both the Lyt 1.1 and Lyt 2.1 surface antigens. A stronger CTL response was noted with the H-2k haplotype compared to H-2d, and...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1988.tb01411.x

    authors: Pang T,Devi S,Blanden RV,Lam SK

    更新日期:1988-01-01 00:00:00

  • In situ infiltration of natural killer-like cells induced by intradermal injection of the nucleic acid fraction from BCG.

    abstract::Intradermal injection of MY-1, a nucleic acid fraction extracted from Mycobacterium bovis strain BCG, induced in situ infiltration of mononuclear cells, most of which were asialo GM1 (GA1)-positive as determined by immunofluorescence microscopy. The infiltration occurred with as little as 1 microgram of MY-1 and laste...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1989.tb00980.x

    authors: Kuramoto E,Toizumi S,Shimada S,Tokunaga T

    更新日期:1989-01-01 00:00:00

  • Phylogenetic analysis of the genus Bifidobacterium and related genera based on 16S rDNA sequences.

    abstract::The 16S rRNA gene sequences were determined for type strains of 21 Bifidobacterium species. A phylogenetic tree was constructed using the determined sequences and sequences from DNA databases, which contain the sequences of 11 type strains of Bifidobacterium species and 11 strains of related genera. All species of the...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1998.tb02337.x

    authors: Miyake T,Watanabe K,Watanabe T,Oyaizu H

    更新日期:1998-01-01 00:00:00