Abstract:
:We examined the effects of microspheres as antigen carriers in mucosal immunization. Shiga toxin B subunits (Stx1B) were adsorbed on 6 mum polystyrene microspheres, which were then intranasally administered to mice together with cholera toxin (CT). Stx1B-specific serum IgG production and secretory IgA production at local mucosal sites were enhanced by the use of microspheres. When OVA was used as a model antigen, secretory IgA production but not serum IgG production was enhanced on the use of microspheres. These results indicated that microspheres provide a useful means of potentiating the immune response against Stx1B with weak immunogenicity.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Kurohane K,Kobayashi C,Imai Ydoi
10.1111/j.1348-0421.2005.tb03714.xkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
149-54issue
2eissn
0385-5600issn
1348-0421pii
JST.JSTAGE/mandi/49.149journal_volume
49pub_type
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journal_title:Microbiology and immunology
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