Mycoplasma pulmonis arthritis in congenitally athymic (nude) mice. Clinical and biological features.

Abstract:

:Congenitally athymic BALB/cA nu/nu mice were employed to elucidate the role of the thymus in experimental Mycoplasma pulmonis strain m53 infection, and nu/+ mice were used for comparison. Chronic polyarthritis was frequently produced in both of nu/nu and nu/+ mice by intravenous injection of the organisms. Macroscopically, nu/nu mice developed severer arthritis and a much lower grade of resolution than nu/+ mice. Periarticular abscess, conjunctivitis, and emaciation were observed in some of the nu/nu mice, but not in the nu/+ mice. Mycoplasmas were isolated from joints and other tissues (including periarticular abscesses and eyelids) of infected nu/nu mice at higher frequencies as well as in greater quantities, and did not show any elimination trends for at least 20 weeks after inoculation. However, nu/+ mice, mycoplasmas were almost exclusively located in joints, and distribution of organisms to the other organs disappeared soon after the infection. Increases in complement-fixing antibody titers were not related to the inhibition of mycoplasmal spread. Thymus-dependent functions that may in some way prevent growth and spread of mycoplasmas in mice are discussed.

journal_name

Microbiol Immunol

authors

Tanaka H

doi

10.1111/j.1348-0421.1979.tb00537.x

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

1055-65

issue

11

eissn

0385-5600

issn

1348-0421

journal_volume

23

pub_type

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