Abstract:
:Murine B cell mitogens such as bacterial lipopolysaccharide (LPS), butanol-extracted water soluble adjuvant (Bu-WSA), dextran sulfate (DS), synthetic muramyl dipeptide (MDP), and its analog MDP-Lys (L18) do not show any mitogenic ability in vitro on human peripheral blood lymphocytes or mixed cell populations of purified T and B cells obtained from the lymphocytes in an ordinary culture system. However, these mitogens are capable of enhancing the mitogenic effect of concanavalin A (Con A) in the cultures. In the presence of one of these mitogens, the activity of interleukin 2 (IL 2), but not interleukin 1, in the supernatants obtained from cultures containing Con A-stimulated T cell and B cell populations was higher than that of control cultures. The role of the newly produced IL 2 in the synergistic effect of the mitogens in human lymphocyte cell cultures was discussed.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Nitta T,Konno-Ejiri H,Okumura S,Ozawa A,Nakano Mdoi
10.1111/j.1348-0421.1985.tb00845.xsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
441-9issue
5eissn
0385-5600issn
1348-0421journal_volume
29pub_type
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