Effect of orally administered non-viable Lactobacillus cells on murine humoral immune responses.

Abstract:

:BALB/c mice were immunized intraperitoneally with the food antigen ovalbumin (OVA) while they were fed with Lactobacillus GG heated killed cell preparation. The oral administration of Lactobacillus GG did not appear to modify the antigen-augmented serum IgE in the tested mice but significantly augmented serum OVA specific IgG in the tested mice fed with a diet containing 0.1% Lactobacillus GG as the non-viable cell preparation (P< 0.05). The fecal OVA specific IgA of the tested mice fed with nonviable Lactobacillus GG cells was also significantly elevated (P< 0.05) compared to those from OVA immunized mice. The spleen cells of mice fed with non-viable Lactobacillus GG cells secreted more IL-6 (P< 0.01). These results suggest that the non-viable Lactobacillus GG can augment the systemic and mucosal immune responses in a host animal favoring secretory IgA but not IgE in an adjuvant-like manner.

journal_name

Microbiol Immunol

authors

He F,Morita H,Kubota A,Ouwehand AC,Hosoda M,Hiramatsu M,Kurisaki J

doi

10.1111/j.1348-0421.2005.tb03695.x

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

993-7

issue

11

eissn

0385-5600

issn

1348-0421

pii

JST.JSTAGE/mandi/49.993

journal_volume

49

pub_type

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