Abstract:
:Staphylococcal exfoliative toxin A (ETA) had a splitting effect at the granular layer of skin in humans and neonatal mice, but not in rabbits, guinea pigs, golden hamsters, or rats. Besides its splitting effect, ETA could stimulate productions of neutralizing antibody to ETA in rabbits, rats and B10D2 mice, but not in golden hamsters, guinea pigs, or ICR, HRS/J, and C57BL/10 mice. In our epidemiological investigation of human sera, the percentage of antibody to ETA in sera obtained from patients with impetigo (8%) was lower than those in sera of healthy males (23%) and females (29%). The relationship between susceptibility and immune response to ETA in these mammalians could be divided into three groups: the possession of resistant skin and high production of antibody to ETA; the possession of resistant skin and low production of antibody to ETA; the possession of sensitive skin and various titers of antibody to ETA.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Machida K,Sakurai S,Kondo I,Ikawa Sdoi
10.1111/j.1348-0421.1988.tb01472.xsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
1079-84issue
10eissn
0385-5600issn
1348-0421journal_volume
32pub_type
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