Deletion polymorphisms in the promoter region of Fcgamma receptor IIB is not associated with antigen-specific IgG2a and IgG2b antibody responses in NC/Nga mice.

Abstract:

:Fcgamma receptor (R) IIB, a low-affinity FcR for IgG, inhibits B cell Ag R (BCR)-mediated activation when these two receptors are cross-linked by Ag and IgG-containing immune complexs (ICs). We found deletion polymorphisms in the promoter region of fcgr2b in NC/Nga mice, a model for human atopic dermatitis. NC/Nga mice produced significantly higher levels of ovalbumin (OVA)-specific IgG, IgG2a and IgG2b than did BALB/c mice. Analysis of (BALB/c x NC/Nga)F1 x BALB/c or (BALB/c x NC/Nga) F1 x NC/Nga backcross mice revealed that deletion polymorphisms of fcgr2b in NC/Nga mice does not directly regulate hyper OVA-specific IgG2a and IgG2b Ab responses.

journal_name

Microbiol Immunol

authors

Sakai T,Kogiso M,Mitsuya K,Komatsu T,Yamamoto S

doi

10.1111/j.1348-0421.2006.tb03817.x

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

475-80

issue

6

eissn

0385-5600

issn

1348-0421

pii

JST.JSTAGE/mandi/50.475

journal_volume

50

pub_type

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