Production of antigenically related exocellular elastolytic proteases mediating hemagglutination by vibrios.

Abstract:

:Exocellular proteases produced by Vibrio fluvialis, V. furnissii, V. metschnikovii and V. campbellii were characterized and compared to those of V. mimicus protease (VMP) and V. vulnificus protease (VVP). These proteases possessed both elastolytic and hemagglutinating abilities and were identified, except that of V. metschnikovii, as metalloprotease. Conversely, V. metschnikovii protease failed to exhibit some of the salient features for metalloproteases suggesting the existence of protease(s) other than metalloprotease. However, antibodies against VVP cross-reacted to these proteases and to VMP indicating antigenic relatedness amongst vibrio proteases. This study, thus, demonstrated the prevalent distributions of antigenically related proteases both in pathogenic and non-pathogenic vibrios, bringing their status as a virulence determinant into question.

journal_name

Microbiol Immunol

authors

Alam M,Miyoshi S,Shinoda S

doi

10.1111/j.1348-0421.1995.tb02170.x

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

67-70

issue

1

eissn

0385-5600

issn

1348-0421

journal_volume

39

pub_type

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