Calcium behavior in endotoxin-poisoned mice: especially calcium accumulation in mitochondria.

Abstract:

:A possible role of intracellular Ca2+ and participation of calmodulin in cellular metabolism in endotoxin-poisoned mice were investigated. The levels of calcium in liver cytosol and liver mitochondria fractions in poisoned mice were markedly higher 18-48 hr after endotoxin injection than in the control mice. On the other hand, the levels of serum calcium in the poisoned mice were about 20% lower at 18 hr than in the controls. The serum calcium levels in mice injected with 50 and 100 micrograms of endotoxin showed no dose-response effect, but a dose-response effect was observed at a dose of 200-400 micrograms. The serum Ca2+ levels in endotoxin-tolerant mice were similar to those in the control mice. The levels in mice injected with glucocorticoid-antagonizing factor mice were about 14% lower at 3 hr than in the controls. The mice fed a vitamin D3- and calcium-free diet showed a higher mortality rate in the early stage (12-18 hr) of endotoxication than that of the mice fed a normal diet. The lipid peroxide levels and Ca2+-ATPase activity in the liver mitochondria fraction in endotoxin-poisoned mice showed a higher level than those of the control mice. There was little or no difference in the levels of serum glucose between the mice injected with calmodulin antagonist (trifluoperazine, TFP) plus endotoxin and those given endotoxin alone. However, the liver glycogen levels in TFP plus endotoxin-treated mice were markedly higher than that in mice given endotoxin alone. Furthermore, calcium antagonist (verapamil) plus endotoxin-treated mice had about a 40% higher survival rate after 72 hr than those given endotoxin alone. The findings suggest that there is a possibility of participation of the Ca2+-calmodulin system in carbohydrate metabolic disorders during endotoxemia and that the changes in intracellular Ca2+ may result in various metabolic disorders.

journal_name

Microbiol Immunol

authors

Sakaguchi S,Abe H,Sakaguchi O

doi

10.1111/j.1348-0421.1984.tb00704.x

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

517-27

issue

5

eissn

0385-5600

issn

1348-0421

journal_volume

28

pub_type

杂志文章
  • Roles of the interactions between Env and Gag proteins in the HIV-1 replication cycle.

    abstract::The Env and Gag proteins of HIV-1 are the two major structural proteins of this retrovirus. The interactions between Env and Gag proteins and their regulation in HIV-1 are required for several steps of the replication cycle, involving not only virus assembly, specifically Env incorporation, but also entry steps after ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1348-0421.2008.00008.x

    authors: Murakami T

    更新日期:2008-05-01 00:00:00

  • A chalcone with potent inhibiting activity against biofilm formation by nontypeable Haemophilus influenzae.

    abstract::Nontypeable Haemophilus influenzae (NTHi), an important human respiratory pathogen, frequently causes biofilm infections. Currently, resistance of bacteria within the biofilm to conventional antimicrobials poses a major obstacle to effective medical treatment on a global scale. Novel agents that are effective against ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12194

    authors: Kunthalert D,Baothong S,Khetkam P,Chokchaisiri S,Suksamrarn A

    更新日期:2014-10-01 00:00:00

  • Effects of tungstosilicate on strains of methicillin-resistant Staphylococcus aureus with unique resistant mechanisms.

    abstract::In a previous study, it was found that polyoxotungstates such as undecatungstosilicate (SiW11) greatly sensitized strains of methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactams. In this report, the effects of SiW11 on several MRSA strains with unique resistant mechanisms were studied. SiW11 was still ef...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2003.tb03388.x

    authors: Tajima Y

    更新日期:2003-01-01 00:00:00

  • In vitro susceptibility of 7.5-kb common plasmid-free Chlamydia trachomatis strains.

    abstract::Using a new plaque cloning technique, we obtained unique Chlamydia trachomatis strains which were confirmed to be free of the 7.5-kb common plasmid and glycogen in inclusions. The in vitro susceptibility of these strains to various chemotherapeutic agents was tested by comparison with their parent strains and clinical...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2000.tb02493.x

    authors: Miyashita N,Matsumoto A,Matsushima T

    更新日期:2000-01-01 00:00:00

  • Immunomodulatory effects of oat beta-glucan administered intragastrically or parenterally on mice infected with Eimeria vermiformis.

    abstract::The immunostimulatory effect of intragastrically or parenterally administered beta-(1-->3; 1-->4) glucan, extracted from oats (ObetaG), on disease resistance to Eimeria vermiformis was studied in C57BL/6 mice. Multiple administrations of ObetaG by intragastric or subcutaneous routes reduced fecal oocyst shedding compa...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1998.tb02309.x

    authors: Yun CH,Estrada A,Van Kessel A,Gajadhar A,Redmond M,Laarveld B

    更新日期:1998-01-01 00:00:00

  • Simple and specific detection of Bordetella holmesii by using a loop-mediated isothermal amplification assay.

    abstract::A loop-mediated isothermal amplification (LAMP) assay for simple detection of Bordetella holmesii was developed. This assay discriminates between B. holmesii and other Bordetella species and successfully detect B. holmesii DNA in nasopharyngeal swab samples from subjects with suspected pertussis. The LAMP assay result...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2012.00465.x

    authors: Otsuka N,Yoshino S,Kawano K,Toyoizumi-Ajisaka H,Shibayama K,Kamachi K

    更新日期:2012-07-01 00:00:00

  • Construction of a slime negative transposon mutant in Staphylococcus epidermidis using the Enterococcus faecalis transposon Tn917.

    abstract::The slime-producing Staphylococcus epidermidis strain sensu strictu CNS23 was transformed by protoplast transformation with the plasmid pTV1 which carries transposon Tn 917. Using this transposon mutagenesis system we obtained the Tn917-inserted mutant CT512, which has lost the ability to produce slime. A single inser...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1993.tb03176.x

    authors: Grüter L,Feucht H,Mempel M,Laufs R

    更新日期:1993-01-01 00:00:00

  • Immunohistochemical distribution of epithelioid cell, myofibroblast, and transforming growth factor-beta1 in the granuloma caused by Mycobacterium avium intracellulare complex pulmonary infection.

    abstract::The present study was designed to evaluate the distribution of epithelioid cells, myofibroblasts, and TGF-beta1 in the formation of granuloma caused by Mycobacterium avium intracellulare complex (MAC) lung infection. A retrospective study was performed for 9 cases of positive MAC culture in which lung resections were ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2002.tb02660.x

    authors: Fujita J,Ohtsuki Y,Suemitsu I,Yamadori I,Shigeto E,Shiode M,Nishimura K,Hirayama T,Matsushima T,Ishida T

    更新日期:2002-01-01 00:00:00

  • Severe invasive streptococcal infection by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis.

    abstract::Streptococcus pyogenes, a group A Streptococcus (GAS), has been recognized as the causative pathogen in patients with severe invasive streptococcal infection with or without necrotizing fasciitis. In recent epidemiological studies, Streptococcus dysgalactiae subsp. equisimilis (SDSE) has been isolated from severe inva...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章,评审

    doi:10.1111/1348-0421.12334

    authors: Watanabe S,Takemoto N,Ogura K,Miyoshi-Akiyama T

    更新日期:2016-01-01 00:00:00

  • Dynamic analysis of expression of chemokine and cytokine gene responses to H5N1 and H9N2 avian influenza viruses in DF-1 cells.

    abstract::H5N1 and H9N2 are the most important causes of avian influenza in China. Chemokines and cytokines play important roles in inflammatory response that clearly differ between H5N1 and H9N2 infection. To investigate whether chemokines and cytokines are differentially regulated following H5N1 and H9N2 AIVs infection, dynam...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12588

    authors: Luo C,Liu J,Qi W,Ren X,Lu R,Liao M,Ning Z

    更新日期:2018-05-01 00:00:00

  • Route-related variation in the immunogenicity of killed Salmonella enteritidis vaccine: role of antigen presenting cells.

    abstract::In order to assess the role of the route of immunization on the immunogenicity of killed Salmonella vaccine, mice were immunized with killed S. enteritidis by intraperitoneal (i.p.) and intradermal (i.d.) routes. Whereas the former was non-immunogenic, the i.d. immunization generated an excellent delayed-type hypersen...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1989.tb01997.x

    authors: George A,Shroff KE,Rath S,Ghosh SN,Sengupta SR,Kamat RS

    更新日期:1989-01-01 00:00:00

  • Antigenic variation of Newcastle disease viruses isolated from wild ducks in Japan.

    abstract::Nineteen strains of Newcastle disease virus (NDV) isolated from wild ducks in Japan were placed into 4 distinct antigenic groups on the basis of their reactivities to 8 monoclonal antibodies against the HN molecule of NDV in hemagglutination inhibition tests. The NDV strains of duck origin were antigenically distinct ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1987.tb03144.x

    authors: Kawamura M,Nagata-Matsubara K,Nerome K,Yamane N,Kida H,Kodama H,Izawa H,Mikami T

    更新日期:1987-01-01 00:00:00

  • Colonization and turnover of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in otitis-prone children.

    abstract::Recurrent otitis media are frequently intractable during childhood. It is unclear whether recurrent otitis media is caused by etiological bacteria colonization or by new infections. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were isolated from the nasopharynx of 7 otitisprone and 2 non-...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2007.tb03904.x

    authors: Yokota S,Harimaya A,Sato K,Somekawa Y,Himi T,Fujii N

    更新日期:2007-01-01 00:00:00

  • Epidemiology of parainfluenza virus types 1, 2 and 3 infections based on virus isolation between 2002 and 2011 in Yamagata, Japan.

    abstract::To clarify the epidemiology of viral acute respiratory infections (ARIs), 305 human parainfluenza virus types 1 (HPIV1), 154 HPIV2 and 574 HPIV3 strains were isolated from 16,962 nasopharyngeal swabs obtained between 2002 and 2011 at pediatric clinics in Yamagata, Japan. The total isolation frequency for HPIV1-3 was 6...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2012.00507.x

    authors: Mizuta K,Abiko C,Aoki Y,Ikeda T,Itagaki T,Katsushima F,Katsushima Y,Matsuzaki Y,Noda M,Kimura H,Ahiko T

    更新日期:2012-12-01 00:00:00

  • Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes.

    abstract::DNase B is a major nuclease and a possible virulence factor in Streptococcus pyogenes. The allelic diversity of streptococcal DNase B (sdaB) gene was investigated in 83 strains with 14 emm genotypes. Of the 15 alleles identified, 11 alleles carried only synonymous nucleotide substitutions. On the other hand, 4 alleles...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2005.tb03684.x

    authors: Matsumoto M,Sakae K,Hashikawa S,Torii K,Hasegawa T,Horii T,Endo M,Okuno R,Murayama S,Hirasawa K,Suzuki R,Isobe J,Tanaka D,Katsukawa C,Tamaru A,Tomita M,Ogata K,Ikebe T,Watanabe H,Ohta M,Working Group for Group A S

    更新日期:2005-01-01 00:00:00

  • Diagnosis of toxic shock syndrome by two different systems; clinical criteria and monitoring of TSST-1-reactive T cells.

    abstract::Two methods of TSS diagnosis were evaluated: comparison of symptoms with clinical criteria and monitoring for evidence of selective activation of Vbeta2(+) T cells by the causative toxin, TSS toxin-1 (TSST-1). Ten patients with acute and systemic febrile infections caused by Staphylococcus aureus were monitored for in...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2008.00071.x

    authors: Matsuda Y,Kato H,Ono E,Kikuchi K,Muraoka M,Takagi K,Imanishi K,Itoh S,Itoh T,Ogawa T,Nitta K,Inokuchi S,Hibi T,Ohta H,Uchiyama T

    更新日期:2008-11-01 00:00:00

  • Regulation of marA, soxS, rob, acrAB and micF in Salmonella enterica serovar Typhimurium.

    abstract::Importance of the overexpression of AcrAB efflux pumps in the low-level resistance of pathogens to antimicrobials requires a better understanding of the AcrAB regulation. The goal of the present research was to study the transcription of acrAB, as well as the genes that play a role in its regulation in Salmonella ente...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2008.00075.x

    authors: Hartog E,Ben-Shalom L,Shachar D,Matthews KR,Yaron S

    更新日期:2008-12-01 00:00:00

  • Isolation and characterization of cytoplasmic fibrils from treponemes.

    abstract::Electron microscopy of Triton X-100-treated whole cells of an oral treponeme, Treponema sp. strain E-21, revealed that six cytoplasmic fibrils (CFs) helically wound as a bundle in the cytoplasm. The CFs were isolated and purified by disruption and solubilization of the cells followed by CsCl density gradient centrifug...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1989.tb02012.x

    authors: Masuda K,Kawata T

    更新日期:1989-01-01 00:00:00

  • RobA-induced multiple antibiotic resistance largely depends on the activation of the AcrAB efflux.

    abstract::RobA is a member of the XylS/AraC subfamily of DNA binding proteins, and when overexpressed, it induces multiple antibiotic resistance in Escherichia coli. In this study, we introduced a multicopy robA plasmid (pMEP1) and its derivative into OmpF mutants and an AcrAB-deficient mutant. We found that a decrease in susce...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1997.tb01913.x

    authors: Tanaka T,Horii T,Shibayama K,Sato K,Ohsuka S,Arakawa Y,Yamaki K,Takagi K,Ohta M

    更新日期:1997-01-01 00:00:00

  • Experimental candida-induced arteritis in mice. Relation to arteritis in the mucocutaneous lymph node syndrome.

    abstract::An extract of Candida albicans isolated from a patient with typical mucocutaneous lymph node syndrome (MCLS) can produce coronary arteritis in a mouse when injected intraperitoneally. An unusual feature of this arteritis is that it is granulomatous, shows no fibrinoid change and is confined to the coronary arteries. T...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1979.tb02815.x

    authors: Murata H

    更新日期:1979-01-01 00:00:00

  • Stenotrophomonas maltophilia interaction with human epithelial respiratory cells in vitro.

    abstract::Bacteria of Stenotrophomonas maltophilia have been isolated with increasing frequency from the airways of cystic fibrosis (CF) patients, usually following P. aeruginosa infections, but their adherence to human epithelial respiratory cells has never been investigated. In this study, various S. maltophilia strains were ...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2001.tb01287.x

    authors: De Vidipó LA,De Marques EA,Puchelle E,Plotkowski MC

    更新日期:2001-01-01 00:00:00

  • Role of tumor necrosis factor-alpha and interferon-gamma in Helicobacter pylori infection.

    abstract::Immune responses to Helicobacter pylori infection play important roles in gastroduodenal diseases. The contributions of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) to the induction of gastric inflammation and to the protection from H. pylori infection were investigated using TNF-alpha gene...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2004.tb03474.x

    authors: Yamamoto T,Kita M,Ohno T,Iwakura Y,Sekikawa K,Imanishi J

    更新日期:2004-01-01 00:00:00

  • Minimal contribution of Valpha14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice.

    abstract::We elucidated the contribution of Valpha14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Valpha14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference i...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2002.tb02687.x

    authors: Kawakami K,Kinjo Y,Uezu K,Yara S,Miyagi K,Koguchi Y,Nakayama T,Taniguchi M,Saito A

    更新日期:2002-01-01 00:00:00

  • Human immunodeficiency virus type 1 neutralization by a single molecule of V3-targeted antibody.

    abstract::Human immunodeficiency virus type-1 (HIV-1) infection generally provokes antibody responses to the viral envelope glycoprotein. Two major regions of gp120, the third variable (V3) domain and the CD4-binding site, have been identified as neutralization targets. The precise mechanism of HIV-1 neutralization by antibodie...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.2002.tb02773.x

    authors: Harada S

    更新日期:2002-01-01 00:00:00

  • Histopathological studies of reactions in mice injected with aluminum-adsorbed tetanus toxoid.

    abstract::Histopathological observations of changes at the injection site in mice were made for 20 weeks after a single intramuscular (im) injection of aluminum hydroxide-adsorbed tetanus toxoid (Alum-TT), plain tetanus toxoid (TT), or aluminum adjuvant (Alum alone). Marked injury to muscle fibers and infiltration of neutrophil...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1982.tb00261.x

    authors: Goto N,Akama K

    更新日期:1982-01-01 00:00:00

  • Heat resistance, spore germination, and enterotoxigenicity of Clostridium perfringens.

    abstract::Heat resistance at 95 C, heat activation at 75 C, and germination response were determined for spores of 10 serotype strains of Clostridium perfringens type A, including five heat-resistant and five heat-sensitive strains. The D95-values ranged from 17.6 to 63.0 and from 1.3 to 2.8 for the heat-resistant and the heat-...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1985.tb00830.x

    authors: Ando Y,Tsuzuki T,Sunagawa H,Oka S

    更新日期:1985-01-01 00:00:00

  • Complete genome sequence and characterization of virulence genes in Lancefield group C Streptococcus dysgalactiae isolated from farmed amberjack (Seriola dumerili).

    abstract::Lancefield group C Streptococcus dysgalactiae causes infections in farmed fish. Here, the genome of S. dysgalactiae strain kdys0611, isolated from farmed amberjack (Seriola dumerili) was sequenced. The complete genome sequence of kdys0611 consists of a single chromosome and five plasmids. The chromosome is 2,142,780 b...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/1348-0421.12716

    authors: Nishiki I,Yoshida T,Fujiwara A

    更新日期:2019-07-01 00:00:00

  • Numerical classification of rapidly growing nonphotochromogenic mycobacteria.

    abstract::Numerical analysis of 211 strains of rapidly growing, nonphotochromogenic mycobacteria was carried out by using 116 characters. New species reported after 1981 and not yet compared with known species by numerical classification were included. At the level of 90% of the matching coefficient, the following species could...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1986.tb03014.x

    authors: Tsukamura M,Ichiyama S

    更新日期:1986-01-01 00:00:00

  • Antiplague antibodies against Yersinia pestis fraction-I antigen in serum from rodents either experimentally infected or captured in harbor areas of Japan, 1971--1977.

    abstract::Antiplague indirect hemagglutination tests were investigated with Yersinia pestis fraction-I antigen and sera from experimentally infected rodents. The same tests with sera treated with acetone or acetone-2-mercaptoethanol were performed in parallel. Technical conditions were determined to insure the specificity and r...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1979.tb00548.x

    authors: Suzuki S,Hotta S

    更新日期:1979-01-01 00:00:00

  • Development and evaluation of capture enzyme-linked immunosorbent assays for detection of immunoglobulin G and M antibodies to group A streptococcal antigens.

    abstract::Capture enzyme-linked immunosorbent assays (ELISAs) were developed to detect immunoglobulin G and M antibodies to group A streptococcal (GAS) antigens, streptolysin O, streptokinase, and group A carbohydrate. The sensitivities and the specificities of the IgM capture ELISAs to each GAS antigen were high enough to dist...

    journal_title:Microbiology and immunology

    pub_type: 杂志文章

    doi:10.1111/j.1348-0421.1993.tb03210.x

    authors: Hayashi S,Yokota K,Takizawa Y,Tomizawa I,Nejime T,Oguma K

    更新日期:1993-01-01 00:00:00