CpG-enriched plasmid enhances the efficacy of the traditional foot-and-mouth disease killed vaccine.

Abstract:

:A CpG-enriched recombinant plasmid (pUC18-CpG) as an adjuvant of FMD killed vaccine was tested for immunization and vaccination challenge in a porcine model. Our preliminary results had indicated that the recombinant plasmid could enhance the humoral immune response triggered by the traditional oil-adjuvant vaccine after the initial inoculation. A subsequent vaccination-challenge test showed an increased PD(50) value. Thus, coadministration of the recombinant plasmid with the oil-adjuvant vaccine helped illicit an immune response earlier than that elicited by giving the vaccine alone. Our results showed that pUC18-CpG can be a potent immunoadjuvant for the traditional FMD killed vaccine and can greatly enhance the traditional vaccine's efficacy when given in combination with it.

journal_name

Microbiol Immunol

authors

Guo X,Jia H,Zhang Q,Yuan W,Zhu G,Xin T,Zhu H,Sánchez-Vizcaíno JM

doi

10.1111/j.1348-0421.2012.00438.x

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

332-7

issue

5

eissn

0385-5600

issn

1348-0421

journal_volume

56

pub_type

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