Abstract:
:We observed the effects of a chinese herb medicine Sho-saiko-to on the lethal and antitumor activities of recombinant human tumor necrosis factor (rhTNF) administered in mice. Sho-saiko-to was noted to protect the rhTNF-induced lethality in galactosamine-hypersensitized mice, and also Sho-saiko-to pretreated mice was protected against the decrease of rectal temperature after rhTNF administration. On the other hand, there was a remarkable enhancement of antitumor activity of rhTNF by Sho-saiko-to pretreatment. These results suggest that Sho-saiko-to drug may protect mice from severe shock syndrome induced by rhTNF.
journal_name
Microbiol Immunoljournal_title
Microbiology and immunologyauthors
Sakaguchi S,Tutumi E,Yokota K,Furusawa S,Sasaki K,Takayanagi Ydoi
10.1111/j.1348-0421.1991.tb01569.xsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
389-94issue
5eissn
0385-5600issn
1348-0421journal_volume
35pub_type
杂志文章abstract::The plasmids R401 and Rtsl belong to the same incompatibility group, IncT. The nucleotide sequence of the basic replicon of R401 consisting of 1,857 base pairs was determined and compared with that of mini-Rtsl previously reported. The mini-R401 was found to be composed of two clusters of direct repeated sequences fla...
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