Preventive effects of a Chinese herb medicine (sho-saiko-to) against lethality after recombinant human tumor necrosis factor administration in mice.

Abstract:

:We observed the effects of a chinese herb medicine Sho-saiko-to on the lethal and antitumor activities of recombinant human tumor necrosis factor (rhTNF) administered in mice. Sho-saiko-to was noted to protect the rhTNF-induced lethality in galactosamine-hypersensitized mice, and also Sho-saiko-to pretreated mice was protected against the decrease of rectal temperature after rhTNF administration. On the other hand, there was a remarkable enhancement of antitumor activity of rhTNF by Sho-saiko-to pretreatment. These results suggest that Sho-saiko-to drug may protect mice from severe shock syndrome induced by rhTNF.

journal_name

Microbiol Immunol

authors

Sakaguchi S,Tutumi E,Yokota K,Furusawa S,Sasaki K,Takayanagi Y

doi

10.1111/j.1348-0421.1991.tb01569.x

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

389-94

issue

5

eissn

0385-5600

issn

1348-0421

journal_volume

35

pub_type

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