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Comparison of murine B cell clonal expansions by synthetic lipid A and muramyl dipeptide analogs.

Abstract：

:Direct stimulations of murine B lymphocytes with synthetic lipid A analogs and synthetic muramyl dipeptide (MDP) derivatives were studied using a limiting dilution assay system. Synthetic lipid A analogs, GLA-27 and GLA-40, when conjugated with bovine serum albumin (BSA) had the ability to induce B cell clonal expansion of a single B cell from the spleen or bone-marrow. Their activities were almost the same as those of naturally obtained lipid A, but were lower than that of bacterial lipopolysaccharide (LPS). Addition of dextran sulfate (DXS) enhanced the effect of lipid A analogs. In contrast, synthetic MDP and its derivatives, although they had many biological and immunological activities in experimental animals, could not stimulate a single B cell to induce clonal expansion regardless of the presence or absence of DXS. These results suggested that lipid A analogs can directly cause the proliferation of B cells, but MDPs can not.

journal_name

Microbiol Immunol

journal_title

Microbiology and immunology

authors

Saito-Taki T,Nakano M,Kiso M,Hasegawa A

doi

10.1111/j.1348-0421.1985.tb00901.x

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

1111-20

issue

11

eissn

0385-5600

issn

1348-0421

journal_volume

29

pub_type

杂志文章

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