Abstract:
:BAFF is associated with various immunological diseases. Previously, we have reported that mouse B cell activating factor (mBAFF) expression was dependent on nuclear localization of co-activator, p300 and the activation of transcription factors including NF-κB and CREB. Here, we investigated whether transcription factor, c-Fos, regulates human (h) BAFF expression through promoter activation by PMA-induced reactive oxygen species (ROS) production. We cloned hBAFF promoter into luciferase-expressing pGL3-basic vector. The activity of 1.0 kb hBAFF promoter was higher than that in 0.75, 0.5 or 0.25 kb hBAFF promoter. The existence of three AP-1 binding motifs was computer-analyzed in hBAFF promoter. The stimulation with PMA and ionomycin (IOM) increased 1.0 kb hBAFF promoter activity, time-dependently. PMA/IOM-stimulation rapidly enhanced c-Fos expression in THP-1 human pro-monocytic cells. Binding of c-Fos to hBAFF promoter was detected by chromatin immunoprecipitation (ChIP) assay. hBAFF expression and its promoter activity were decreased by the transfection with small interference (si) RNA of c-Fos. ROS production in THP-1 cells was increased by PMA/IOM-stimulation. In addition, hBAFF activity stimulated by PMA/IOM was reduced by N-acetyl-cysteine (NAC), a well-known ROS scavenger. Serum starvation (0.5% FBS) producing ROS and the exogenous H(2)O(2) treatment also enhanced hBAFF promoter activity. c-Fos expression and AP-1 binding to oligonucleotide were reduced by the treatment with NAC. H(2)O(2) was not able to induce hBAFF expression in the presence of staurosporine, PKC inhibitor. Data suggest that hBAFF expression could be regulated by promoter activation through c-Fos association, which might be dependent on PMA-induced ROS production.
journal_name
Cytokinejournal_title
Cytokineauthors
Lee GH,Lee MH,Yoon YD,Kang JS,Pyo S,Moon EYdoi
10.1016/j.cyto.2012.03.017subject
Has Abstractpub_date
2012-07-01 00:00:00pages
115-23issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(12)00100-7journal_volume
59pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::Nerve growth factor (NGF), which is a neurotrophic factor, is involved in autoimmune and inflammatory processes. Serum NGF levels were investigated in 131 patients with autoimmune (95 with Graves' disease, of whom 57 had ophthalmopathy, 19 with Hashimoto's thyroiditis) and nonimmune thyroid diseases (17 with toxic nod...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2006.08.002
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN:Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human In...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.08.010
更新日期:2007-11-01 00:00:00
abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::Estrogens have been associated with risk for epithelial ovarian cancer (OVCA). Both IL-6 and IL-8 are also likely involved in the progression of OVCA. In order to discover the underline molecular mechanism, we investigated the modulation of estrogen and two cytokines in the growth and progression of epithelial OVCA. I...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.013
更新日期:2009-06-01 00:00:00
abstract::Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.06.006
更新日期:2009-09-01 00:00:00
abstract::This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.12.026
更新日期:2017-04-01 00:00:00
abstract::The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90047-7
更新日期:1994-11-01 00:00:00
abstract::Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM [GDM Group - 20 managed with diet only (GDM...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.09.006
更新日期:2013-01-01 00:00:00
abstract::Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.06.315
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:In pregnancy, the placental contribution of cytokines to maternal immunosuppression has been established, however their role in normal maternal blood pressure regulation has not been identified. We investigate the contribution of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) to the vasod...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.10.011
更新日期:2005-02-21 00:00:00
abstract::We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.06.008
更新日期:2006-06-01 00:00:00
abstract::Ureaplasma species (spp.) are considered commensals of the adult urogenital tract, but may cause chorioamnionitis and preterm birth as well as sepsis and meningitis in neonates. Pathomechanisms in Ureaplasma-driven neuroinflammation are largely unknown. This study addressed mRNA and protein expression of intercellular...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154737
更新日期:2019-09-01 00:00:00
abstract::Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155049
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:We had previously reported metabolic abnormalities in TNF-treated weight-gaining (WG) rats, associated with increased soluble and membrane TNF receptors. OBJECTIVE:On the basis of these findings, we hypothesized that stabilization of TNF in circulation in WG animals by these receptors augmented the action o...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00105-4
更新日期:2003-06-21 00:00:00
abstract::Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 kn...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.06.009
更新日期:2014-10-01 00:00:00
abstract::It is well known that interleukin (IL)-1 is a potent activator of the hypothalamo-pituitary-adrenal axis in the rat. Many studies have reported that prostaglandins (PGs), especially PGE2, in the brain may mediate the IL-1 stimulation of corticotropin-releasing hormone release, which then leads to adrenocorticotropin (...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0083
更新日期:1995-10-01 00:00:00
abstract::Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0512
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.09.007
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.022
更新日期:2013-10-01 00:00:00
abstract::Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0478
更新日期:1999-09-01 00:00:00
abstract::Invariant Natural Killer T (iNKT) cells represent a population of innate T lymphocytes which act as 'first-responders' to infection. While they have long been considered a versatile cell, capable of secretion of multiple cytokines upon activation, recent evidence now indicates that distinct lineages of iNKT cells with...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2014.12.005
更新日期:2015-04-01 00:00:00
abstract::The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.04.003
更新日期:2008-07-01 00:00:00
abstract:AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155261
更新日期:2020-12-01 00:00:00
abstract::Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations dur...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0674
更新日期:2000-07-01 00:00:00
abstract::The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation. ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2015.03.001
更新日期:2015-08-01 00:00:00
abstract::Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0786
更新日期:2000-12-01 00:00:00
abstract::Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.03.009
更新日期:2007-02-01 00:00:00
abstract::Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2009.07.007
更新日期:2009-10-01 00:00:00
abstract::The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0060
更新日期:1996-06-01 00:00:00
abstract::Coronary artery disease (CAD) results from atherosclerosis, a chronic inflammatory disease mediated in part by proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α), which is expressed by atherosclerotic plaques. In this study, we investigated whether TNF-α gene promoter polymorphisms affect the inci...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.008
更新日期:2013-04-01 00:00:00