Abstract:
:Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1]. The TRUC (T-bet-/- RAG2-/- ulcerative colitis) model is discussed in the broader context of the adaptive and innate immune mechanisms that regulate host-commensal relationships within the intestine.
journal_name
Cytokinejournal_title
Cytokineauthors
Garrett WS,Glimcher LHdoi
10.1016/j.cyto.2009.07.007subject
Has Abstractpub_date
2009-10-01 00:00:00pages
144-7issue
1-2eissn
1043-4666issn
1096-0023pii
S1043-4666(09)00184-7journal_volume
48pub_type
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