Regulation of interleukin IL-4, IL-13, IL-10, and their downstream components in lipopolysaccharide-exposed rat lungs. Comparison of the constitutive expression between rats and humans.

abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

journal_title：Cytokine

authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

更新日期：2020-03-01 00:00:00

abstract：:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...

journal_title：Cytokine

authors： Dowrick PG,Prescott AR,Warn RM

更新日期：1991-07-01 00:00:00

abstract：:HIV infection is associated with chronic inflammation in both non-treated and treated patients. TLR-dependent mechanisms are strongly involved in the maintenance of this inflammation. Indeed, the residual replication of HIV, the potential viral co-infections, or the products issued from microbial translocation provide...

journal_title：Cytokine

authors： Leite Pereira A,Tchitchek N,Marcos Lopez E,Lambotte O,Le Grand R,Cosma A

更新日期：2018-11-01 00:00:00

abstract：:Cytokines are involved in the pathogenesis of community acquired pneumonia (CAP). The aim of this study is to investigate the association of IL6-174 G/C gene polymorphism with CAP in Egyptian children, to assess its effect on CAP outcome and to determine its effect on the serum IL6 levels in these children. IL6-174 G/...

journal_title：Cytokine

authors： Zidan HE,Elbehedy RM,Azab SF

更新日期：2014-06-01 00:00:00

abstract：:Estrogens have been shown to markedly modulate the immune system. One mechanism by which estrogens could modulate the immune system is by regulating cytokines, an aspect not well-studied thus far. To address this issue, normal C57BL/6 orchiectomized mice were given estrogen and its effects on selected cytokines, inter...

journal_title：Cytokine

authors： Karpuzoglu-Sahin E,Zhi-Jun Y,Lengi A,Sriranganathan N,Ansar Ahmed S

更新日期：2001-05-21 00:00:00

abstract：OBJECTIVES:To measure the serum and synovial fluid (SF) levels of interleukin (IL)-37 in patients with rheumatoid arthritis (RA) and to investigate the effect of recombinant human (rh)IL-37 on inflammatory cytokine production (tumor necrosis factor [TNF]-α, IL-6, IL-17 and IL-10) by peripheral blood mononuclear cells (...

journal_title：Cytokine

authors： Xia L,Shen H,Lu J

更新日期：2015-12-01 00:00:00

abstract：:Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induc...

journal_title：Cytokine

authors： Vreugdenhil GR,Wijnands PG,Netea MG,van der Meer JW,Melchers WJ,Galama JM

更新日期：2000-12-01 00:00:00

abstract：:To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...

journal_title：Cytokine

authors： Tanabe Y,Kitahara-Tanabe N,Mizuno D,Soma GI

更新日期：1994-07-01 00:00:00

abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

journal_title：Cytokine

authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

更新日期：2013-06-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...

journal_title：Cytokine

authors： Yuan X,Shan Y,Zhao Z,Chen J,Cong Y

更新日期：2006-02-21 00:00:00

abstract：:Leprosy is an infectious disease caused by M. leprae. We analyzed 48 cytokine polymorphisms in 13 (pro as well as anti-inflammatory) cytokine genes using PCR-SSP assay in 102 leprosy patients and 120 healthy controls with intent to find out a link between cytokine polymorphisms and disease susceptibility. TNF-α (-308)...

journal_title：Cytokine

authors： Tarique M,Naqvi RA,Santosh KV,Kamal VK,Khanna N,Rao DN

更新日期：2015-05-01 00:00:00

abstract：:IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...

journal_title：Cytokine

authors： Scott LM,Bryant AH,Rees A,Down B,Jones RH,Thornton CA

更新日期：2017-11-01 00:00:00

abstract：:The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...

journal_title：Cytokine

authors： Berger MS,Taub DD,Orlofsky A,Kleyman TR,Coupaye-Gerard B,Eisner D,Cohen SA

更新日期：1996-06-01 00:00:00

abstract：:The oligoadenylate synthetase (OAS) family of enzymes are interferon-inducible antiviral proteins, which synthesize the secondary messenger 2'-5'-linked oligoadenosine (2-5A) in response to viral infection. The production of 2-5As induces RNA decay within the infected cells, thereby effectively preventing further vira...

journal_title：Cytokine

authors： Wang Y,Holleufer A,Gad HH,Hartmann R

更新日期：2020-02-01 00:00:00

abstract：:Clara cell protein (CC16) is an endogenous anti-inflammatory agent. It is produced mainly in the respiratory and urogenital tracts. CC16 has been quantified in serum, but not in cerebrospinal fluid (CSF). The aim of this study was to examine CSF CC16 in relation to age, gender and serum CC16, and to examine CC16 level...

journal_title：Cytokine

authors： De Jongh R,Vranken J,Kenis G,Bosmans E,Maes M,Stans G,De Ley M,Heylen R

更新日期：1998-06-01 00:00:00

abstract：AIMS:This study investigates the relationships between matrix metalloproteinases, inflammations mediators and type 2 diabetes mellitus in Tunisians metabolic syndrome (Mets) patients. METHODS:The study has included 239 MetS patients and 247 controls. Mets was defined according to the NCEP-ATPIII report. Mets patients ...

journal_title：Cytokine

authors： Zayani Y,El Golli N,Zidi W,Guizani I,Boussairi S,Aloui S,Ayadi I,Ftouhi B,Feki M,Ben Romdhane N,Ben Sliman H,Allal-Elasmi M,Kaabachi N

更新日期：2016-10-01 00:00:00

abstract：:Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Th...

journal_title：Cytokine

authors： Silva GA,Naveca FG,Ramasawmy R,Boechat AL

更新日期：2014-02-01 00:00:00

abstract：:We have studied the effects of rhTGF-beta2, dexamethanosome (dex) and 1,25(OH)2D3 on human bone marrow stromal (HBMS) cells in long-term culture. A fraction on HBMS expressed type I collagen (Col I) and osteopontin, and transient treatment (48 h) with dex increased the number of alkaline phosphatase (ALP) positive cel...

journal_title：Cytokine

authors： Fromigué O,Marie PJ,Lomri A

更新日期：1997-08-01 00:00:00

abstract：:Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...

journal_title：Cytokine

authors： Sunderland NS,Thomson SE,Heffernan SJ,Lim S,Thompson J,Ogle R,McKenzie P,Kirwan PJ,Makris A,Hennessy A

更新日期：2011-11-01 00:00:00

abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

journal_title：Cytokine

authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

更新日期：2016-12-01 00:00:00

abstract：:The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

journal_title：Cytokine

authors： Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

更新日期：1992-11-01 00:00:00

abstract：:The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M;...

journal_title：Cytokine

authors： Savarese TM,Campbell CL,McQuain C,Mitchell K,Guardiani R,Quesenberry PJ,Nelson BE

更新日期：2002-03-21 00:00:00

abstract：:Malignant ascites of epithelial ovarian cancer patients contains high levels of interleukin 6 (IL-6). The present study was conducted to compare the secretion of IL-6 by seven different human ovarian cancer cell lines (OVCA) and cultured human peritoneal mesothelial cells (HPMC) and to examine the regulation of its pr...

journal_title：Cytokine

authors： Offner FA,Obrist P,Stadlmann S,Feichtinger H,Klingler P,Herold M,Zwierzina H,Hittmair A,Mikuz G,Abendstein B

更新日期：1995-08-01 00:00:00

abstract：:Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...

journal_title：Cytokine

authors： Rubil S,Lesch A,Mukaida N,Thiel G

更新日期：2018-03-01 00:00:00

abstract：:Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI w...

journal_title：Cytokine

authors： Trivedi J,Shaikh J,Chavan N,Thorve D,Chaudhary B,Karade A,Gupta S,Patel A,Bhagwat S

更新日期：2020-05-01 00:00:00

abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

journal_title：Cytokine

authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

更新日期：2008-12-01 00:00:00

abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...

journal_title：Cytokine

authors： Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...

journal_title：Cytokine

authors： Teijeira-Fernandez E,Eiras S,Shamagian LG,Somoza AS,Delgado C,Gonzalez-Juanatey JR

更新日期：2011-05-01 00:00:00

abstract：:FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those adhesion molecules on human vascular endothelial cells (HMVEC). Culture supernatant from peripheral blood mononuclea...

journal_title：Cytokine

authors： Sasakawa T,Sasakawa Y,Masunaga T,Fujitsu T,Hirayama Y,Ohkubo Y,Mutoh S

更新日期：2005-01-21 00:00:00

abstract：:We examined the possible alteration of circulating transforming growth factor-beta1 (TGF-beta1) concentrations in a time-dependent fashion in human plasma. Plasma TGF-beta1 was measured three times at 2 week-intervals from each of 12 healthy participants. Platelet factor 4 (PF4) was measured in parallel with TGF-beta1...

journal_title：Cytokine

authors： Jeon JH,Kim YS,Choi EJ,Cheon S,Kim S,Kim JS,Jang JS,Ha WS,Park ST,Park CS,Park K,Park BK

更新日期：2001-11-07 00:00:00